Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase [0.03%]
热带 Psychotria 植物是人源脯氨酰寡肽酶肽抑制剂的丰富来源
Roland Hellinger,Paula Schwarz,Jonathan Dieringer et al.
Roland Hellinger et al.
Peptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are a notable class, yet their distribution, diversity, and targets remain underexplored. Here, eleven tropical Psychotri...
Sophflarines F-K: matrine-based alkaloids with a rare aromatic system from Sophora flavescens and their anti-inflammatory and synergistic antibacterial effects [0.03%]
少花木蓝中托品烷类生物碱Sophflarine F-K的首次发现及其抗炎和抗菌增效作用研究
Ding Luo,Le-Yan Wang,Xiang-Feng Zhao et al.
Ding Luo et al.
Six new matrine-based alkaloids, sophflarines F-K (1-6), featuring a rare aromatic system, were obtained from the water-soluble alkaloid fractions of Sophora flavescens by UV-guided separation. Their structures were elucidated by the interp...
Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism [0.03%]
limonene及其代谢产物perillyl醇通过改变宿主异戊二烯代谢来抑制沙眼衣原体的生长
Pilar Cebollada,Inés Reigada,Maarit Ylätalo et al.
Pilar Cebollada et al.
The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted infection globally, with approximately 131 million new cases each year. It contributes to widespread reproductive health issues, in...
Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial-mesenchymal transition [0.03%]
脱乙酰 форсколин通过抑制炎症和TGF-β1诱导的上皮间质转化来改善博莱霉素诱发的肺纤维化
Yan Zhong,Chuang Xiao,Yaping Liang et al.
Yan Zhong et al.
Pulmonary fibrosis (PF) is a chronic, progressive and irreversible inflammatory disease with limited therapeutic methods in clinic. Deacetylforskolin (DFSK), derived from the plant Coleus forskohlii, is a potent adenylyl cyclase activator w...
GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits [0.03%]
基于富蛋白酶果实分离获得的真菌的GNPS2分子网络研究揭示了其代谢多样性
Vitor de Souza Mazucato,Winner Duque Rodrigues,Ludmilla Tonani et al.
Vitor de Souza Mazucato et al.
Fungi are a rich source of chemical diversity for bioprospecting, yet most of their metabolic potential remains unexplored. This study investigated the metabolic profile of phytopathogenic fungi of the genus Fusarium, isolated from fruits w...
Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression [0.03%]
通过异源表达隐秘生物合成基因簇发现前所未有的牻牛儿基吲哚哌嗪和吡嗪类化合物
Ziou Zha,Dan He,Jianguo Song et al.
Ziou Zha et al.
Prenylation modifications of natural products typically introduce greater structural complexity and enhance their biological activities. Yet, the modification of piperazine alkaloids by dimethylallyl tryptophan synthases (DMATS) remains unr...
Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii [0.03%]
hypericum przewalskii 中无芳香基异戊烯化缩氨蝶呤的分离、全合成及生物评价
Yong Li,Fei-Fei Xiong,Xiao-Yang Sun et al.
Yong Li et al.
New dearomatized isoprenylated acylphloroglucinols hyperprzewones A (1) and B (2) were isolated and characterized from the dried aerial parts of Hypericum przewalskii. The structures of these compounds were confirmed by extensive spectrosco...
Pyridone alkaloids from an Antarctic endolichenic Tolypocladium sp [0.03%]
南极地衣内生菌Tolypocladium sp.中的吡啶酮生物碱类化合物
Shasha Li,Ting Yu,Jianju Feng et al.
Shasha Li et al.
Three new pyridone alkaloids, tolypyrone A (1), tolypyrosides A (2) and B (3), and a new tetramic acid 2'-epitolypoalbin (4), along with ten known compounds, were obtained from Tolypocladium sp. CPCC 401485 isolated from an unidentified Ant...
Advances in natural coumaronochromones: a comprehensive review of natural occurrence, bioactivities, and chemical synthesis [0.03%]
天然香豆酮木酚素研究进展：发生、生物活性及化学合成综述
Dan Xia,Qin Lv,Wei Wang et al.
Dan Xia et al.
Coumaronochromones, characterized by a distinctive benzofuro[2,3-b]chromenone core, constitute a rare subclass of isoflavonoids. Biosynthetically, they are proposed to originate from carbohydrate metabolism and the phenylpropanoid pathway l...
Natural triterpenoid Ardisiacrispin B attenuates colitis-associated cancer via JAK2/STAT3 pathway and gut microbiota modulation [0.03%]
天然三萜化合物毛蕊子碱B通过JAK2/STAT3信号通路和调节肠道菌群抑制结肠炎相关癌症发生发展
Hidayat Ullah,Huanli Cui,Yu Li et al.
Hidayat Ullah et al.
Colitis-associated cancer (CAC) arises from persistent intestinal inflammation, immune dysregulation, and microbiota-driven epithelial injury, representing a major link between inflammatory bowel disease and colorectal malignancy. Despite a...