Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A [0.03%]
天然产物假层孔菌酸A的作用靶点可能是甲基四氢叶酸脱氢酶-1类蛋白：鉴定与验证研究
Haoqi Dong,Xinni Yang,Peiying Wang et al.
Haoqi Dong et al.
Natural product pseudolaric acid A (PAA), the main bioactive component from Traditional Chinese Medicine Pseudolarix cortex ("tujingpi"), is a promising anticancer agent. However, its potential molecular targets are not clear and this hinde...
Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans [0.03%]
丛枝杆胞菌和颤杆菌共培养中分离的摇奶酮衍生物
Jinjuan Wei,Zhe-Xi Li,Gao-Ke Peng et al.
Jinjuan Wei et al.
The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical investigation on the co-cultures of the two congeneric fungi led to the isolation of eleven new vibralactone derivatives, ...
Newly isolated terpenoids (covering 2019-2024) from Aspergillus species and their potential for the discovery of novel antimicrobials [0.03%]
新近分离的来自曲霉属物种的萜类化合物（涵盖2019-2024年）及其在发现新型抗菌物质方面的潜力
Olusesan Ojo,Idris Njanje,Dele Abdissa et al.
Olusesan Ojo et al.
The rapid emergence of drug-resistant microbial pathogens has posed challenges to global health in the twenty-first century. This development has significantly made most antibiotics ineffective in the treatment of infections they cause, res...
Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella [0.03%]
来自鼠刺根的具有细胞毒性的十新型五环三萜苷化合物Asprecosides A-J
Yuwei Wu,Baihui Zhang,Wenxian Li et al.
Yuwei Wu et al.
Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (1-9) and one oleanane-type glycoside (10), along with seven known c...
Emestrin-type epipolythiodioxopiperazines from Aspergillus nidulans with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways [0.03%]
来自烟曲霉的具有细胞毒活性的Emestrin型多硫代二氧哌嗪通过调节PI3K / AKT和线粒体凋亡途径
Pengkun Li,Qin Li,Aimin Fu et al.
Pengkun Li et al.
Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C-G (1-5), along with two known ETPs, prenylemestrin A (6) and prenylemestrin B (7), were obtained from Aspergillus nidulans. Their structures were characterized b...
Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds [0.03%]
高级的RPL19-TRAPKI-seq方法揭示了生物活性化合物的作用机制
Di Zhu,Junchi Hu,Renke Tan et al.
Di Zhu et al.
Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecular targets and insufficient research on mechanisms of action. In this study, we developed a new RPL19-TRAPKI-seq metho...
Structure-function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications [0.03%]
天然灵芝多糖的结构功能研究：生物合成及功能性食品应用的新进展
Zhou-Wei Wu,Xue-Fang Zhao,Chen-Xi Quan et al.
Zhou-Wei Wu et al.
Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, including immune modulation, anti-tumor effects, and gut microbiota regulation. These properties position GPs as dual-purpo...
Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents [0.03%]
布他丁类衍生物的设计、合成及心脏保护活性评价
Yuan Liu,Fa-Qi Wang,Xin-Hao Hua et al.
Yuan Liu et al.
Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte inju...
Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023) [0.03%]
海洋天然产物作为新型抗肿瘤药物来源的综述(2019-2023)
Hesham R El-Seedi,Mohamed S Refaey,Nizar Elias et al.
Hesham R El-Seedi et al.
Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances ma...
Joan Labara Tirado,Andrei Herdean,Peter J Ralph
Joan Labara Tirado
Microalgae's adaptability and resilience to Earth's diverse environments have evolved these photosynthetic microorganisms into a biotechnological source of industrially relevant physiological functions and biometabolites. Despite this, micr...