Exploring the antineoplastic potential of α-mangostin in breast cancer [0.03%]
评价α-紫花素对乳腺癌的抗肿瘤潜力 исследование抗肿瘤潜力 của α-紫花素对乳腺癌的影响
Daniela Amador-Martínez,Mizraim Flores,Rafael Vargas-Castro et al.
Daniela Amador-Martínez et al.
Among women, breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mortality globally. Despite improvements in early detection and diagnosis, some risk factors have been on the rise, including the dec...
Bioprospecting cultivable bacteria associated with deep sea (mesopelagic) fish of the North Atlantic Ocean [0.03%]
北 Atlantic 海洋深海鱼类相关培养菌的生物勘探研究
Ernest Oppong-Danquah,Jana Heumann,Hannah Moosbauer et al.
Ernest Oppong-Danquah et al.
The microbiota associated with fish is increasingly recognized as a valuable source of bioactive metabolites for pharmaceutical application. The mesopelagic zone, a deep and unique ecosystem with a diverse biological community, is among the...
Review on NMR spectroscopic data and recent analytical methods of aristolochic acids and derivatives in Aristolochia herbs [0.03%]
防己酮类和降香树脂茋类生物碱核磁共振数据及相关分析方法进展研究综述
Phan Minh Giang,Nguyen Nghia Vu,Vu Thanh Loc et al.
Phan Minh Giang et al.
Aristolochic acids (AAs) are an important group of secondary metabolites in the genus Aristolochia. The presence of aristolochic acids infers the potency of many Aristolochia herbs used for ages in traditional medicine of China, Europe, Cen...
Discovery of structurally diverse polyprenylated acylphloroglucinols with quorum sensing inhibitory activity from Hypericum seniawinii Maxim [0.03%]
来自Hypericum seniawinii Maxim的具有群体淬灭作用的结构多样的聚戊烯基化茋及茋寡聚体类成分的发现
Yulin Duan,Xiaoxia Gu,Xincai Hao et al.
Yulin Duan et al.
Four previously undescribed polyprenylated acylphloroglucinols, hyperisenins A-D (1-4), along with two known analogues (5 and 6), were obtained from the aerial part of Hypericum seniawinii Maxim. Compounds 1 and 2 were two highly degraded p...
Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D [0.03%]
探究抗SARS-CoV-2天然产物：飞燕草素的双病毒靶标抑制作用以及北沙参皂苷D的抗冠状病毒功效
Jiani Lu,Yan Tang,Hongtao Li et al.
Jiani Lu et al.
Qingfei Paidu decoction (QFPDD) has been extensively used in clinical treatments during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic. SARS-CoV-2 primarily invades host cells via its spike (S) protein binding to ...
Design of 20-deoxyingenol-esters-based PKC agonists and their lysosome biogenesis-enhancing activity [0.03%]
一类PKC激动剂的设计及其促进溶酶体生物发生活性研究
Jia-Jia Wan,Qiu-Yuan Yin,Mao Sun et al.
Jia-Jia Wan et al.
The activation of conventional (α) and novel (δ) protein kinase C (PKC) isoforms promotes lysosomal biogenesis, a critical process for clearance of pathogenic protein aggregates including β-amyloid (Aβ) and phosphorylated Tau (p-Tau) in...
Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics in Staphylococcus aureus and Acinetobacter baumannii [0.03%]
伏泰和百里香酚联合抗生素对抗金黄色葡萄球菌及鲍曼不动杆菌的协同作用机制及其耐药预防研究
Cristina Gan,Elisa Langa,Gang Wang et al.
Cristina Gan et al.
The use of natural products as antibiotic adjuvants to enhance efficacy and mitigate resistance is increasingly recognized as a promising strategy. This study explored five novel synergistic antimicrobial combinations (SACs) of carvacrol (C...
Bridging chemical space and biological efficacy: advances and challenges in applying generative models in structural modification of natural products [0.03%]
化学空间与生物活性的桥梁：在天然产物结构修饰中应用生成模型的优势和挑战
Chuan-Su Liu,Bing-Chao Yan,Han-Dong Sun et al.
Chuan-Su Liu et al.
Natural products (NPs) are invaluable resources for drug discovery, characterized by their intricate scaffolds and diverse bioactivities. AI drug discovery & design (AIDD) has emerged as a transformative approach for the rational structural...
Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro [0.03%]
枸杞叶抗风湿活性成分研究
Zi-Jiao Wang,Bang-Yin Tan,Yun Zhao et al.
Zi-Jiao Wang et al.
Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1-34 were evaluated for their anti-rheumat...
Polyprenylated acylphloroglucinols from Garcinia species and structural revision of seven analogues [0.03%]
钩藤属植物茋类茋 glucophloguinol 的聚戊烯基化酰化及七种类似物的结构修正
Yong-Ge Fu,Yi-Qi Huang,Zhi-Hong Xu et al.
Yong-Ge Fu et al.
Our continuous study of the fruits of Garcinia xanthochymus and Garcinia subelliptica led to the isolation and structural characterization of six new polyprenylated acylphloroglucinols, xanthochymusones N and O (1 and 2), (-)-garciyunnanin ...