Identifying genetics biomarkers in correlation with pathological and PSMA PET/CT characteristics in prostate cancer [0.03%]
前列腺癌的遗传生物标志物鉴定及其与病理和PSMA-PET/CT特征相关性的研究
Lili Qu,Kaiyue Li,Muwen Wang et al.
Lili Qu et al.
Background: Prostate cancer is a prevalent disease with diverse tumor characteristics that complicate treatment. The integration of spatial patterns from prostate-specific membrane antigen (PSMA) positron emission tomogra...
[18F]MNI-1054, a novel PET ligand for lysine-specific histone demethylase 1 A (LSD1): first-in human validation and enzyme occupancy of the LSD1 inhibitor TAK-418 [0.03%]
新型PET配体[18F]MNI-1054（赖氨酸特异性组蛋白脱甲基酶1A的配体（LSD1）：首次人体验证和LSD1抑制剂TAK-418的酶占用率研究
Adam J Schwarz,Christine M Sandiego,Cristian Constantinescu et al.
Adam J Schwarz et al.
Background: The enzyme lysine-specific histone demethylase 1 (LSD1) epigenetically regulates gene expression and is a pharmacological target of interest in neurology. The aims of this study were to characterize the novel ...
Automatic lesion segmentation in ⁶⁸Ga-PSMA PET/CT and ¹⁷⁷Lu-PSMA SPECT/CT: added value of PET-guided SPECT in a bicentric study [0.03%]
一项双中心研究：PET引导的SPECT在68Ga-PSMA PET/CT和177Lu-PSMA SPECT/CT病灶分割中的附加价值
Solène Perret,Léa Albe,Agathe Edet-Sanson et al.
Solène Perret et al.
Background: Manual segmentation of prostate cancer metastases on PSMA PET/CT and SPECT/CT is time-consuming and poorly scalable, particularly in highly metastatic patients. This study evaluated nnU-Net-based automatic seg...
The impact of PSMA-PET/CT on clinical decision-making in primary staging of prostate cancer [0.03%]
PSMA-PET/CT在前列腺癌初始分期临床决策中作用的影响
Jacob Ingvar,Rasmus Green,Elin Trägårdh et al.
Jacob Ingvar et al.
Background: Accurate staging is essential for optimal management of prostate cancer. Conventional imaging with computed tomography and bone scintigraphy has limited sensitivity and specificity, particularly for small-volu...
Can chatGPT-4o reliably standardize PSMA PET/CT and PET/MRI reports using PROMISE V2 criteria? - An exploratory study [0.03%]
使用PROMISE V2标准评估ChatGPT-4在PSMA PET/CT和PET/MRI报告标准化方面的可靠性——一项探索性研究
Anna Hinterberger,Maurin H Mangold,Caroline Weigel et al.
Anna Hinterberger et al.
Background: Structured reporting standardizes and facilitates reporting, improves accurate communication, and ultimately clinical decision-making. Although standardized frameworks such as PROMISE criteria are available fo...
Long-term outcomes in medullary thyroid cancer patients treated with [177Lu]Lu-DOTAGA.FAPi dimer therapy [0.03%]
[177Lu]Lu-DOTAGA.FAPi二聚体治疗甲状腺髓样癌患者的长期疗效分析
Sanjana Ballal,G B Priyanka,Madhav Prasad Yadav et al.
Sanjana Ballal et al.
Background: Fibroblast activation protein (FAP)-targeted radionuclide therapy is a promising approach for patients with advanced or metastatic medullary thyroid carcinoma (MTC). This study evaluates efficacy, safety, and ...
Construction and clinical application of a predictive model for the efficacy of ¹³¹I therapy in refractory Graves' disease in children and adolescents [0.03%]
儿童和青少年难治性Graves病¹³₁I治疗有效性的预测模型构建及临床应用研究
Qianyu Chen,Zhiyuan Deng,Qianyu Deng et al.
Qianyu Chen et al.
Background: Radioactive iodine (RAI) is a crucial treatment for refractory pediatric and adolescent Graves' disease (GD) cases characterized by poor response to antithyroid drug (ATD), recurrence, adverse effects, or exce...
Outcome after primary directed radiotherapy in predominantly PSMA-PET/CT-staged patients with metastatic prostate cancer [0.03%]
PSMA-PET/CT分期的转移性前列腺癌患者初始放射治疗后的疗效
Christian Trapp,Sarah Frederike Brose,Michael Keilholz et al.
Christian Trapp et al.
Background: Oligometastatic prostate cancer (OMPC) is typically treated with systemic therapy, which may be complemented by radiotherapy (RT) of the prostate as part of primary directed therapy (PDT). This study retrospec...
Cardiopulmonary transit time measured on dynamic rubidium cardiac PET/CT is a predictor for pulmonary hypertension [0.03%]
动态钾心脏PET/CT测量的心肺转运时间是预测肺动脉高压的一个指标
Lena C Seige,Jakob Heimer,Karsten Murray et al.
Lena C Seige et al.
Background: Cardiopulmonary transit time (CPTT), the time for blood to circulate from the right to the left ventricle, can be assessed on dynamic Rubidium-82 ([82Rb]) cardiac PET/CT. Given its association with cardiac and...
Dual-time-point [18F]FDG-PET/CT as a prognostic biomarker in patients with pleural mesothelioma undergoing immunotherapy [0.03%]
双重时间点~(18)F-FDG-PET/CT作为免疫治疗中胸膜间皮瘤患者的预后生物标志物
Solfrid Thunold,Eivor Hernes,Lars Tore Gyland Mikalsen et al.
Solfrid Thunold et al.
Background: [18F]FDG PET/CT provides a non-invasive assessment of tumour glucose metabolism. While conventional PET/CT captures a single time point, dual-time-point PET/CT (DTP-PET) evaluates metabolic dynamics by acquiri...