Multicentre analysis of PET SUV using vendor-neutral software: the Japanese Harmonization Technology (J-Hart) study [0.03%]
基于供应商中立软件的多中心PET SUV分析：日本标准化技术(J-Hart)研究
Yuji Tsutsui,Hiromitsu Daisaki,Go Akamatsu et al.
Yuji Tsutsui et al.
Background: Recent developments in hardware and software for PET technologies have resulted in wide variations in basic performance. Multicentre studies require a standard imaging protocol and SUV harmonization to reduce ...
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model [0.03%]
抗PD-1治疗增加小鼠B16F10黑色素瘤模型中癌细胞的[18F]FDG摄取量
Mayu Tomita,Hironobu Yasui,Kei Higashikawa et al.
Mayu Tomita et al.
Background: Programmed cell death 1 (PD-1) inhibitors act as immune checkpoint inhibitors and are more effective for improving survival time with less toxicity as compared with conventional chemotherapies. In anti PD-1 th...
Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats [0.03%]
利福平可抑制的运输对大鼠体内厄洛替尼肝脏分布和组织动力学的影响：正电子发射断层扫描成像评估
Dorra Amor,Sébastien Goutal,Solène Marie et al.
Dorra Amor et al.
Background: Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of e...
In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET [0.03%]
FDG-PET体内成像系统性RNA癌症疫苗引起的免疫反应
Stefanie Pektor,Lina Hilscher,Kerstin C Walzer et al.
Stefanie Pektor et al.
Background: [18F]Fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET) is commonly used in the clinic for diagnosis of cancer and for follow-up of therapy outcome. Additional to the well-established value in t...
A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus [0.03%]
一种新颖的体积部分修正方法，用于海马区[18F] flortaucipir的精确量化
Emma E Wolters,Sandeep S V Golla,Tessa Timmers et al.
Emma E Wolters et al.
Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed us...
Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: towards improved alpha-therapeutics [0.03%]
高效制备惰性Bi-213螯合物的四磷酸DOTA类似物：用于改善α放射治疗药物
Jakub Šimeček,Petr Hermann,Christof Seidl et al.
Jakub Šimeček et al.
Background: The recently growing interest in targeted alpha-therapy (TAT) calls for improvement of the labelling chemistry of the corresponding radionuclides. 213BiIII is a short-lived alpha emitter which emits only one a...
Correlation of the absorbed dose to the blood and DNA damage in leukocytes after internal ex-vivo irradiation of blood samples with Ra-224 [0.03%]
224Ra体外辐照下血液样品吸收剂量与白细胞DNA损伤的相关性研究
Sarah Schumann,Uta Eberlein,Jessica Müller et al.
Sarah Schumann et al.
Background: Irradiation with α-particles creates densely packed damage tracks along particle trajectories in exposed cells, including complex DNA damage and closely spaced double-strand breaks (DSBs) in hit nuclei. Here,...
Patient-specific image-based bone marrow dosimetry in Lu-177-[DOTA0,Tyr3]-Octreotate and Lu-177-DKFZ-PSMA-617 therapy: investigation of a new hybrid image approach [0.03%]
基于患者影像的骨髓剂量学在镥-177-[DOTA0，Tyr3]-奥曲肽和镥-177-DKFZ-PSMA-617治疗中的研究：一种新的混合影像方法的研究
Astrid Gosewisch,Andreas Delker,Sebastian Tattenberg et al.
Astrid Gosewisch et al.
Background: The bone marrow (BM) is a main organ at risk in Lu-177-PSMA-617 therapy of prostate cancer and Lu-177-Octreotate therapy of neuroendocrine tumours. BM dosimetry is challenging and time-consuming, as different ...
The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist [0.03%]
新型金属放射性核素锝标记生长抑素受体2拮抗剂的研究-tetaamine螯合物优于HYNIC
Keelara Abiraj,Samer Ursillo,Maria Luisa Tamma et al.
Keelara Abiraj et al.
Background: Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the r...
Whole tumor kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow [0.03%]
非小细胞肺癌患者18F氟霉.iso唑动态正电子发射体层扫描的肿瘤整体动力学分析及其与灌注CT血流量的相关性研究
Daniel R McGowan,Michael Skwarski,Bartlomiej W Papiez et al.
Daniel R McGowan et al.
Background: To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumor uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using...