Milos Kostic,Nikola Zivkovic,Ana Cvetanovic et al.
Milos Kostic et al.
The formation of amyloid-β (Aβ) plaques is a neuropathological hallmark of Alzheimer's disease (AD), however, these pathological aggregates can also be found in the brains of cognitively unimpaired elderly population. In that context, ind...
Comparison of data-driven thresholding methods using directed functional brain networks [0.03%]
基于定向功能脑网络的阈值法比较研究
Thilaga Manickam,Vijayalakshmi Ramasamy,Nandagopal Doraisamy
Thilaga Manickam
Over the past two centuries, intensive empirical research has been conducted on the human brain. As an electroencephalogram (EEG) records millisecond-to-millisecond changes in the electrical potentials of the brain, it has enormous potentia...
Unraveling mitochondrial dysfunction: comprehensive perspectives on its impact on neurodegenerative diseases [0.03%]
解开线粒体功能障碍之谜：其对神经退行性疾病影响的全面视角
Abdul Aziz Mohamed Yusoff,Siti Zulaikha Nashwa Mohd Khair
Abdul Aziz Mohamed Yusoff
Neurodegenerative diseases represent a significant challenge to modern medicine, with their complex etiology and progressive nature posing hurdles to effective treatment strategies. Among the various contributing factors, mitochondrial dysf...
The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals [0.03%]
运动干预在自闭症患者中的作用机制的神经生物学研究
Genghong Tu,Nan Jiang,Weizhong Chen et al.
Genghong Tu et al.
Autism spectrum disorder is a pervasive and heterogeneous neurodevelopmental condition characterized by social communication difficulties and rigid, repetitive behaviors. Owing to the complex pathogenesis of autism, effective drugs for trea...
Role of endothelial glycocalyx in central nervous system diseases and evaluation of the targeted therapeutic strategies for its protection: a review of clinical and experimental data [0.03%]
神经系统的血管内皮糖萼在中枢神经系统疾病中的作用及其保护靶向治疗策略的评估：临床和实验数据综述
Weihao Ye,Shang Xu,Ying Liu et al.
Weihao Ye et al.
Central nervous system (CNS) diseases, such as stroke, traumatic brain injury, dementia, and demyelinating diseases, are generally characterized by high morbidity and mortality, which impose a heavy economic burden on patients and their car...
A review of the application of exercise intervention on improving cognition in patients with Alzheimer's disease: mechanisms and clinical studies [0.03%]
运动干预改善阿尔茨海默病患者认知功能的应用研究：机制与临床试验回顾
Man Wang,Yan Hua,Yulong Bai
Man Wang
Alzheimer's disease (AD) is the most common form of dementia, leading to sustained cognitive decline. An increasing number of studies suggest that exercise is an effective strategy to promote the improvement of cognition in AD. Mechanisms o...
Eng Han How,Shar-Maine Chin,Chuin Hau Teo et al.
Eng Han How et al.
Major depressive disorder (MDD) patients commonly encounter multiple types of functional disabilities, such as social, physical, and role functioning. MDD is related to an accreted risk of brain atrophy, aging-associated brain diseases, and...
Current potential diagnostic biomarkers of amyotrophic lateral sclerosis [0.03%]
肌萎缩侧索硬化症当前潜在的诊断生物标志物
Zheqi Xu,Renshi Xu
Zheqi Xu
Amyotrophic lateral sclerosis (ALS) currently lacks the useful diagnostic biomarkers. The current diagnosis of ALS is mainly depended on the clinical manifestations, which contributes to the diagnostic delay and be difficult to make the acc...
Revealing the mechanisms of blood-brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention [0.03%]
揭示慢性神经退行性疾病中血脑屏障的机制：治疗干预的机会
Sixun Yu,Xin Chen,Tao Yang et al.
Sixun Yu et al.
The brain microenvironment is tightly regulated, and the blood-brain barrier (BBB) plays a pivotal role in maintaining the homeostasis of the central nervous system. It effectively safeguards brain tissue from harmful substances in peripher...
Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases [0.03%]
星形胶质细胞源外泌体在神经退行性疾病发生发展及治疗中的研究进展
Yifan Zhu,Fangsheng Wang,Yu Xia et al.
Yifan Zhu et al.
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), pose significant global health risks and represent a substantial public health co...