Multimodal CT-based imaging biomarkers for mechanical reperfusion in acute ischemic stroke [0.03%]
急性缺血性卒中机械再灌注的多模态CT影像生物标志物
Runjianya Ling,Feng Shi,Yueqi Zhu
Runjianya Ling
Mechanical thrombectomy (MT) has emerged as the primary treatment for restoring blood flow in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). The shift from "time is brain" to "tissue is brain" underscores the signif...
Orchestrating pathogenesis: copper ions as the conductor of molecular dysfunction in Parkinson's disease and therapeutic avenues [0.03%]
orchestrating病理发病：铜离子在帕金森病分子功能障碍中的作用及治疗途径
Zhe Zhang,Yanning Cai,Lingling Lu
Zhe Zhang
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the abnormal aggregation of α-synuclein (α-Syn) into Lewy bodies. Whil...
From cells to vesicles: mechanisms and therapeutic promise of cell- and exosome-based interventions in ischemic stroke [0.03%]
从细胞到囊泡：缺血性卒中细胞和外泌体治疗的机制及前景分析
Naeimeh Akbari-Gharalari,Amin Aghadoost,Ehsan Maroofi et al.
Naeimeh Akbari-Gharalari et al.
With the growing burden of ischemic stroke as a leading cause of mortality and long-term disability worldwide, the demand for innovative and effective therapeutic strategies has become increasingly urgent. Traditional interventions offer li...
Valentina N Mal&#x;tseva,Sergei G Gaidin,Artem M Kosenkov
Valentina N Mal&#x;tseva
Epilepsy is one of the most prevalent neurological disorders, and approximately one-third of patients remain resistant to current pharmacological treatments. This underscores the urgent need for innovative therapeutic strategies targeting n...
Microstructural alterations of the amygdala in neurodegenerative and neuroinflammatory disorders: insights from diffusion tensor imaging [0.03%]
扩散张量成像对神经退行性疾病和神经炎症疾病下杏仁核结构变化的观察
Marjan Falahati,Kiana Orangi,Alireza Shaabanpoor Haghighi et al.
Marjan Falahati et al.
Diffusion tensor imaging (DTI) is a valuable method for evaluating microstructural changes in the amygdala associated with neurodegenerative and neuroinflammatory disorders. This systematic review examines amygdala microstructural alteratio...
Probiotics and seizure susceptibility in preclinical epilepsy models: mechanistic insights from a systematic review and meta-analysis [0.03%]
益生菌与癫痫前疾病模型的发作易感性：系统评价和meta分析的机制启示
Leila Simani,Etrat Hooshmandi,Razieh Hajisoltani et al.
Leila Simani et al.
The gut microbiota can affect neuronal excitability, inflammation, and oxidative balance via the gut-brain axis, shaping seizure susceptibility. To translate these findings into clinical approaches, a synthesis of preclinical microbiome-bas...
The dual role of TRPC channel-mediated dysregulation of calcium signaling in regulating mitophagy in early brain injury after subarachnoid hemorrhage [0.03%]
TRPC通道介导的钙信号失调在蛛网膜下腔出血后早期脑损伤中的双重作用及其对线粒体自噬的调节作用
Jieqiong Yang,Yan Zou,Xudong Zhao
Jieqiong Yang
Subarachnoid hemorrhage (SAH) induces early brain injury (EBI) through mechanisms involving mitochondrial dysfunction and dysregulated calcium signaling. Transient receptor potential canonical (TRPC) channels are critical mediators of calci...
Marziah Hakim,Peytn Stokes-Marshall,Kate Beecher et al.
Marziah Hakim et al.
The researchers who conduct, author and review neuroscience studies inherently shape both the findings and the segments of society that ultimately benefit from the research. Generally, Western high-income nations dominate the production and...
The role of emotion in economic decision making: behavioral and neurophysiological evidence from the Wheel of Fortune Gambling Task [0.03%]
来自幸运之轮赌博任务的行为和神经生理学证据表明情绪在经济决策中的作用
Tingting Zhang,Ronald Kipkirui Ngetich,Junjun Zhang et al.
Tingting Zhang et al.
Decision making is frequently influenced by factors such as an individual's emotional state, cognitive biases, social influences, and environmental constraints. Understanding how these factors influence the way decisions are made is essenti...
Fast cortical oscillations as a potential network mechanism for language processing [0.03%]
快速皮层振荡作为语言处理的潜在网络机制
Roger D Traub,Mark O Cunningham,Nikolaus Maier et al.
Roger D Traub et al.
Since the 19th century, the study of brain mechanisms of language has depended on available tools: the clinical study of language-impaired patients, with neuropathological correlates, in the style of Broca and Wernicke; imaging techniques i...