Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson's disease [0.03%]
帕金森病左旋多巴诱导的异动症的神经基础和潜在治疗方法
Joseph R Phillips,Abeer M Eissa,Doaa H Hewedi et al.
Joseph R Phillips et al.
Parkinson's disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, s...
John S Y Chan,Yifeng Wang,Jin H Yan et al.
John S Y Chan et al.
The human brain works as a synergistic system where information exchanges between functional neuronal networks. Rudimentary networks are observed in the brain during infancy. In recent years, the question of how functional networks develop ...
Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis [0.03%]
睡眠和昼夜节律在调节多巴胺与精神病方面的作用——精神分裂症中的证据
Nathanael James Yates
Nathanael James Yates
Schizophrenia has long been associated with abnormalities in circadian rhythms and sleep. Up until now, there have been no thorough reviews of the potential mechanisms behind the myriad of circadian and sleep abnormalities observed in schiz...
Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases [0.03%]
基于肠降糖素的2型糖尿病治疗有望用于神经退行性疾病的治疗
Yanwei Li,Lin Li,Christian Hölscher
Yanwei Li
Incretin hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Due to their promising action on insulinotropic secretion and improving insulin resistance (IR), incretin-based therapies have...
Synaptic and extrasynaptic traces of long-term memory: the ID molecule theory [0.03%]
长期记忆的突触和非突触痕迹：ID分子理论
Charles R Legéndy
Charles R Legéndy
It is generally assumed at the time of this writing that memories are stored in the form of synaptic weights. However, it is now also clear that the synapses are not permanent; in fact, synaptic patterns undergo significant change in a matt...
The role of the low-density lipoprotein receptor-related protein 1 (LRP-1) in regulating blood-brain barrier integrity [0.03%]
低密度脂蛋白受体相关蛋白1调节血脑屏障完整性的功能研究
Yahui Zhao,Dandong Li,Junjie Zhao et al.
Yahui Zhao et al.
The blood-brain barrier (BBB) is a protective structure that helps maintaining the homeostasis in cerebral microenvironment by limiting the passage of molecules into the brain. BBB is formed by closely conjugated endothelial cells, with ast...
Role of hippocampal activity-induced transcription in memory consolidation [0.03%]
海马活动诱导性转录在记忆巩固中的作用
Andrew L Eagle,Paula A Gajewski,Alfred J Robison
Andrew L Eagle
Experience-dependent changes in the strength of connections between neurons in the hippocampus (HPC) are critical for normal learning and memory consolidation, and disruption of this process drives a variety of neurological and psychiatric ...
Deciphering variability in the role of interleukin-1β in Parkinson's disease [0.03%]
解读白细胞介素-1β在帕金森病中作用的变异性
Amene Saghazadeh,Carina C Ferrari,Nima Rezaei
Amene Saghazadeh
Although the role of inflammation in neurodegeneration has been well acknowledged, less is known on the issue of each cytokine in specific neurodegenerative diseases. In this review, we will present evidence elucidating that interleukin-1β...
Phytochemicals as future drugs for Parkinson's disease: a comprehensive review [0.03%]
植物化学物质作为治疗帕金森病的未来药物：综述性研究
Zahra Shahpiri,Roodabeh Bahramsoltani,Mohammad Hosein Farzaei et al.
Zahra Shahpiri et al.
Parkinson's disease (PD) is the second most common chronic neurodegenerative disease that affects motor skills and cognitive performance. The conventional therapeutic approaches for the management of PD are just able to alleviate symptoms. ...
The dose makes the poison: from glutamate-mediated neurogenesis to neuronal atrophy and depression [0.03%]
剂量决定毒性：从谷氨酸介导的神经发生到神经元萎缩和抑郁
Alberto Rubio-Casillas,Alonso Fernández-Guasti
Alberto Rubio-Casillas
Experimental evidence has demonstrated that glutamate is an essential factor for neurogenesis, whereas another line of research postulates that excessive glutamatergic neurotransmission is associated with the pathogenesis of depression. The...