From lactate to lactylation: potential targets for the treatment of neurodegenerative diseases [0.03%]
从乳酸到乳酰化：神经退行性疾病治疗的潜在靶点
Bingbing Wang,Shenghao Qian,Caizhen Shi et al.
Bingbing Wang et al.
Traditionally, lactate is regarded as a byproduct of anaerobic metabolism. With the deepening of related research, the roles of lactate in cellular energy metabolism, signal transduction, and microenvironment regulation have attracted incre...
Farhad Mashayekhi,Zivar Salehi
Farhad Mashayekhi
Autism spectrum disorder (ASD) is a condition that is defined by difficulties in social interactions, communication challenges, and repetitive behaviors. ASD is a common condition, with a significant rise in the number of diagnosed children...
Antimicrobial peptides and proteins in Alzheimer's and Parkinson's diseases: implications for biomarker exploration [0.03%]
抗菌肽和蛋白质在阿尔茨海默病和帕金森病中的作用：生物标志物探索的启示
Shin Jie Yong,Seong Lin Teoh,Ishwar S Parhar et al.
Shin Jie Yong et al.
Biomarkers are necessary tools to validate the diagnosis of Alzheimer's and Parkinson's diseases (AD and PD), especially when clinical symptoms are less apparent in the early stages of diseases. Current biomarkers used in clinical practice ...
From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer's disease [0.03%]
从遗传根源到针对阿尔茨海默病β淀粉样蛋白的基因治疗最新进展
Pinar Peyvand,Pantea Allami,Nima Rezaei
Pinar Peyvand
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. The pathological hallmarks of AD are amyloid-beta (Aβ) plaques and tau protein tangles, which cause neurodegeneration and lead to cognitive decline. The dis...
The current approaches to modeling the brain ischemia-reperfusion and inflammation: from animal models toward vascularized and neuroimmune cerebral organoids [0.03%]
脑缺血再灌注及炎症的建模方法：从动物模型到血管化和神经免疫类脑器官
Pavel P Tregub,Daria D Volegova,Arseniy K Berdnikov et al.
Pavel P Tregub et al.
For several decades, the modeling of brain diseases in experimental animals has remained one of the key components of studying the pathogenesis of central nervous system pathology and searching for new methods of prevention and therapy. In ...
Exercise-induced modulation of miRNAs and gut microbiome: a holistic approach to neuroprotection in Alzheimer's disease [0.03%]
运动诱导的miRNA和肠道微生物组的调节：阿尔茨海默病神经保护的整体方法
Rui Wang,Juan Li,Xiaochen Li et al.
Rui Wang et al.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is marked by cognitive decline, neuroinflammation, and neuronal loss. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression, influencing key pathways in...
A proposed role for electrical coupling in the neocortical slow oscillation [0.03%]
关于新皮质慢振荡中电偶联的假设作用
Roger D Traub,Andreas Draguhn,Diego Contreras et al.
Roger D Traub et al.
We constructed a computational thalamocortical network model for study of the neocortical slow oscillation. It incorporated a number of neuronal types, both excitatory and inhibitory, each model neuron simulated as a multicompartment entity...
Gamma oscillations as correlates of depression: updating Fitzgerald and Watson (2018) [0.03%]
抑郁的伽马振荡特征：更新Fitzgerald和Watson(2018)的观点
Sarah L Coleman,Christopher F Sharpley,Kirstan A Vessey et al.
Sarah L Coleman et al.
Depression remains one of the most common and debilitating neuropsychiatric conditions, with little consistency in treatment efficacy. Some of the lack of success in developing effective treatments has been the absence of a reliable biomark...
The role of glutamate receptors and transporters in epilepsy: evidence from animal studies [0.03%]
谷氨酸受体和转运蛋白在癫痫中的作用：来自动物实验的证据
Jéssica Alves Lemes,Barbara Dos Anjos Rosário,Sophia Morya Santos Rocha et al.
Jéssica Alves Lemes et al.
Epilepsy encompasses a group of chronic brain disorders characterized by recurrent, hypersynchronous activity of neuronal clusters, with epileptic seizures being the primary manifestation of these disorders. The objective of epilepsy treatm...
Neuroinflammation in diabetic peripheral neuropathy and therapeutic implications [0.03%]
糖尿病外周神经病理性炎症及治疗意义
Zhao Zhong Chong,Nizar Souayah
Zhao Zhong Chong
Diabetic peripheral neuropathy (DPN) is a serious complication of diabetes mellitus, which is a common cause of disability in individuals with diabetes mellitus. Multiple mechanisms may be involved in the development of DPN. Neuroinflammati...