In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs [0.03%]
C6胶质瘤体内模型研究进展及脑胶质瘤药物筛选模型指导建议
Safura Pournajaf,Nastaran Afsordeh,Mohammad Hossein Pourgholami
Safura Pournajaf
Glioblastoma multiform (GBM) is the most common primary brain tumor with a poor prognosis and few therapeutic choices. In vivo, tumor models are useful for enhancing knowledge of underlying GBM pathology and developing more effective therap...
Fine-tuning the circadian system with light treatment for Parkinson's disease: an in-depth, critical review [0.03%]
光照治疗帕金森病的生物节律系统：深入而批判性的综述研究
Gregory L Willis,Stuart M Armstrong
Gregory L Willis
Late in the twentieth century, interest intensified regarding the involvement of the circadian system in the aetiology and treatment of Parkinson's disease (PD). It has been envisaged that this approach might provide relief beyond the limit...
Peripheral inflammation is a potential etiological factor in Alzheimer's disease [0.03%]
外周炎症可能是阿尔茨海默病的致病因素
Ziyuan Li,Hui Wang,Yafu Yin
Ziyuan Li
Peripheral inflammation could constitute a risk factor for AD. This review summarizes the research related to peripheral inflammation that appears to have a relationship with Alzheimer's disease. We find there are significant associations b...
Pathogenesis underlying hexanucleotide repeat expansions in C9orf72 gene in amyotrophic lateral sclerosis [0.03%]
C9orf72基因六核苷酸重复扩增在肌萎缩侧索硬化病理发生中的作用
Zhao Zhong Chong,Daniel L Menkes,Nizar Souayah
Zhao Zhong Chong
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder. Mutations in C9orf72 and the resulting hexanucleotide repeat (GGGGCC) expansion (HRE) has been identified as a major cause of familial ALS, a...
Involvement of microglia in chronic neuropathic pain associated with spinal cord injury - a systematic review [0.03%]
小胶质细胞在脊髓损伤相关慢性神经病理性疼痛中作用的系统评价
David Ramos,Célia Duarte Cruz
David Ramos
In recent decade microglia have been found to have a central role in the development of chronic neuropathic pain after injury to the peripheral nervous system. It is widely accepted that peripheral nerve injury triggers microglial activatio...
Mahsa Golshani Nasab,Arash Heidari,Mohammadreza Sedighi et al.
Mahsa Golshani Nasab et al.
Neuropsychiatric disorders (NPDs) are considered a potential threat to mental health. Inflammation predominantly plays a role in the pathophysiology of NPDs. Dietary patterns are widely postulated to be involved in the physiological respons...
Natalia Favila,Kevin Gurney,Paul G Overton
Natalia Favila
Integrating individual actions into coherent, organised behavioural units, a process called chunking, is a fundamental, evolutionarily conserved process that renders actions automatic. In vertebrates, evidence points to the basal ganglia - ...
A review of neuroimaging-based data-driven approach for Alzheimer's disease heterogeneity analysis [0.03%]
基于神经影像的阿尔茨海默病异质性分析的数据驱动方法进展及展望回顾
Lingyu Liu,Shen Sun,Wenjie Kang et al.
Lingyu Liu et al.
Alzheimer's disease (AD) is a complex form of dementia and due to its high phenotypic variability, its diagnosis and monitoring can be quite challenging. Biomarkers play a crucial role in AD diagnosis and monitoring, but interpreting these ...
Alexander Ya Rodnyy,Elena M Kondaurova,Anton S Tsybko et al.
Alexander Ya Rodnyy et al.
Autism spectrum disorders (ASDs) are among the most common neurodevelopmental diseases. These disorders are characterized by lack of social interaction, by repetitive behavior, and often anxiety and learning disabilities. The brain serotoni...
Transsulfuration pathway: a targeting neuromodulator in Parkinson's disease [0.03%]
转硫化途径：帕金森病的神经调节靶点
Andrea Corona-Trejo,María E Gonsebatt,Cristina Trejo-Solis et al.
Andrea Corona-Trejo et al.
The transsulfuration pathway (TSP) is a metabolic pathway involving sulfur transfer from homocysteine to cysteine. Transsulfuration pathway leads to many sulfur metabolites, principally glutathione, H2S, taurine, and cysteine. Key enzymes o...