Rodrigo W Alves de Souza,Hyo In Kim,Paula Ketilly Nascimento Alves et al.
Rodrigo W Alves de Souza et al.
Background: Heme oxygenases, HO-1 (Hmox1) and HO-2 (Hmox2), regulate skeletal muscle homeostasis by degrading heme and generating carbon monoxide (CO), a bioactive signalling molecule. Although HO-1 is known to influence ...
Home-Based Intervention to Prevent Functional Decline in (Pre)frail Older Adults: The PromeTheus Randomized Controlled Trial [0.03%]
在家进行的干预措施以预防老年人身体功能下降：PromeTheus随机对照试验
Kilian Rapp,Corinna Nerz,Tim Fleiner et al.
Kilian Rapp et al.
Background: Older adults with (pre)frailty are vulnerable to deteriorations in physical functioning, mobility and independence. Evidence for frailty interventions utilizing existing services within primary healthcare stru...
Randomized Controlled Trial
Journal of cachexia, sarcopenia and muscle. 2026 Jun;17(3):e70306. DOI:10.1002/jcsm.70306 2026
Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti-GDF-15 Antibody-Based Combination Therapies [0.03%]
靶向癌症恶病质：基于抗GDF-15抗体的联合治疗的机制评估
Danna M Breen,Stephanie Joaquim,Brianna LaCarubba Paulhus et al.
Danna M Breen et al.
Background: In a recent Phase 2 trial in patients with cancer cachexia, the anti-GDF-15 antibody ponsegromab resulted in increased body weight, appetite, muscle mass and physical activity. This study provides compelling e...
MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo [0.03%]
一种新颖的报告系统用于检测体外和体内早期肌肉萎缩
Andrea D Re Cecconi,Nicoletta Rizzi,Mara Barone et al.
Andrea D Re Cecconi et al.
Background: Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to ide...
Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity [0.03%]
用于评估老年人肌少症肥胖相关轻度认知障碍的新型生物标志物：三酰甘油-葡萄糖-腰围/体重指数
Yue Xing,Qian Liu,Xiangfeng He et al.
Yue Xing et al.
Background: Sarcopenic obesity (SO) is closely associated with mild cognitive impairment (MCI). However, traditional body composition-based diagnostic criteria for SO fail to adequately incorporate insulin resistance, a k...
RAGE Re-Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions [0.03%]
癌症条件下肌纤维水平的炎症再表达驱动肌肉萎缩
Sara Chiappalupi,Giulia Gentili,Laura Salvadori et al.
Sara Chiappalupi et al.
Background: Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end-products (RAGE) is expres...
PACS2 Alleviates Sepsis-Induced Myopathy by Activating ERK-MAPK Signalling Pathway to Suppress ER-Phagy [0.03%]
PACS2通过激活ERK-MAPK信号通路抑制ER-phagy缓解脓毒症肌病
Xuexin Li,Zu-An Shi,Fei He et al.
Xuexin Li et al.
Background: Sepsis-induced myopathy (SIM) is a common and life-threatening complication, but its underlying mechanisms remain poorly understood. PACS2, a key resident protein at mitochondria-associated endoplasmic reticul...
Prevalence and Prognostic Impact of the Coexistence of Cachexia and Sarcopenia in Patients With Chronic Liver Diseases [0.03%]
肝病患者恶病质和肌少症并存的流行病学及预后影响研究
Takatsugu Tanaka,Goki Suda,Masatsugu Ohara et al.
Takatsugu Tanaka et al.
Background: Cachexia and sarcopenia are prevalent, inflammation-linked syndromes in chronic liver disease that worsen outcomes. To our knowledge, their coexistence in a single chronic liver disease cohort has not been sys...
Effectiveness and Safety of Interventions for Sarcopenia in Advanced Prostate Carcinoma: Systematic Review [0.03%]
晚期前列腺癌患者肌少症干预的有效性和安全性系统评价
Pedro de Pablos-Rodríguez,Aythami de Armas-Castellano,Diego Infante-Ventura et al.
Pedro de Pablos-Rodríguez et al.
Background: Sarcopenia has emerged as a potential prognostic factor in patients with advanced prostate cancer (PCa), requiring interventions for its prevention and treatment. ...