Early Identification and Prognostic Stratification of Cancer Cachexia Using Explainable Machine Learning: A Multicentre Cohort Study [0.03%]
基于可解释机器学习的癌症恶病质的早期识别与预后分层：一项多中心队列研究
Wei Huang,Kan Pan,Mingjian Zhao et al.
Wei Huang et al.
Background: Cancer cachexia is a heterogeneous syndrome that remains frequently underrecognized in routine oncology care, especially before overt wasting develops. We aimed to develop and externally validate an explainabl...
Observational Study
Journal of cachexia, sarcopenia and muscle. 2026 Aug;17(4):e70370. DOI:10.1002/jcsm.70370 2026
Cachexia vs. Obesity: A Persisting Imbalance Between Clinical Need and Research Effort [0.03%]
恶病质与肥胖：临床需求与研究努力之间的持久失衡
Carolyn Blair,Alexander P Maxwell,Adrian Slee et al.
Carolyn Blair et al.
Normative Reference Values and Cut-Off Points for Nutritional Ultrasound: The VALORES Study [0.03%]
营养超声的参考值和切点：VALORES 研究
Carolina Moreno-Torres-Taboada,José M Romero-Márquez,María García-Olivares et al.
Carolina Moreno-Torres-Taboada et al.
Background: Nutritional ultrasound (NU) enables direct assessment of skeletal muscle and adipose tissue, yet population-based reference values and cut-offs remain scarce. We aimed to establish age- and sex-specific normat...
Multicenter Study
Journal of cachexia, sarcopenia and muscle. 2026 Aug;17(4):e70344. DOI:10.1002/jcsm.70344 2026
Heyang Zhang,Guotian Ruan,Zelin Chai et al.
Heyang Zhang et al.
Background: Systemic inflammation is associated with cancer prognosis, but commonly used inflammatory indices show limited discrimination across heterogeneous malignancies. We developed and validated a novel inflammatory ...
Blood Biomarkers of Alzheimer's Disease and Gait Speed Trajectories in Community-Dwelling Older Adults: A Cohort Study [0.03%]
社区老年人阿尔茨海默病血生物标志物与步速轨迹的相关性：队列研究
Javier Leal-Martín,Giulia Grande,Caterina Gregorio et al.
Javier Leal-Martín et al.
Background: Gait speed (GS) has been suggested as a predictor of incident dementia in old age. However, the mechanisms underlying this body-mind connection remain unclear, and it is still unknown whether trajectories of G...
Intermuscular Adipose Tissue as a Multimodality Quantitative Imaging Biomarker: Evidence Across Metabolic, Cardiovascular and Oncologic Diseases [0.03%]
跨代谢、心血管和肿瘤疾病的多模式定量影像生物标志物：肌间脂肪组织
Feier Ding,Atsushi Nakamoto,Xiaohan Zheng et al.
Feier Ding et al.
Intermuscular adipose tissue (IMAT) refers to adipose tissue located between muscle groups or beneath the muscle fascia, and its accumulation is closely linked to impaired muscle quality, reduced contractile function, and adverse metabolic ...
Accelerated Anthropometric Ageing Links Loss of Physical Function and Lower Extremity Body Mass [0.03%]
加速体质老化与身体机能下降和下肢肌肉量减少之间的联系
Qu Tian,Suha Shin,Katie Bustin et al.
Qu Tian et al.
Background: Ageing is associated with anthropometric changes that have been linked to functional limitations and disease risk. However, previous work is limited to a few anthropometric measures, such as body mass index or...
Supervised Exercise Intervention Restores Physical Activity and MultiOMIC-Derived Frailty Biomarkers in Older Adults [0.03%]
基于多组学的虚弱生物标志物在老年人中的监管运动干预研究
Diego Marcos-Perez,Sara Cruces-Salguero,Morelva Saeteros et al.
Diego Marcos-Perez et al.
Background: The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals...
Multicenter Study
Journal of cachexia, sarcopenia and muscle. 2026 Aug;17(4):e70362. DOI:10.1002/jcsm.70362 2026
Global Epidemiology of Amputation-Related Disability From 1990 to 2021: Geographic Variation and Projections to 2050 [0.03%]
1990至2021年全球截肢相关残疾流行病学特征及其2050年的变化趋势预测
Xuhui Cuan,Jianguang Zhang,Zhuowen Lu et al.
Xuhui Cuan et al.
Background: Amputation is a critical event leading to the permanent loss of limb function and long-term functional impairment, posing a substantial burden on global healthcare systems. However, the global burden, demograp...
Waist-to-Body Mass Index Ratio and Risk of Musculoskeletal Disease in Type 2 Diabetes: A Cohort and PhIP-Seq Analysis [0.03%]
腰体质量指数比值与2型糖尿病患者肌肉骨骼疾病风险的关系：队列及PhIP-Seq分析
Yongze Zhang,Luxi Lin,Lifeng Zheng et al.
Yongze Zhang et al.
Background: Musculoskeletal complications in type 2 diabetes (T2DM) are inadequately captured by body mass index (BMI). Waist-to-BMI ratio (WBR) may better reflect adverse body composition. We examined cross-sectional and...