Exploring topical atorvastatin hyalurosomal gel as an adjuvant for reducing systemic corticosteroid dosage: a randomized clinical trial in severe oral lichen planus patients [0.03%]
探讨伏立康唑透明质酸凝胶作为减少重症口腔扁平苔藓全身皮质类固醇剂量辅助手段的临床疗效：一项随机对照试验
Mahitab Elsayed,Aya Essawy,Radwa M Ismail et al.
Mahitab Elsayed et al.
Oral lichen planus (OLP) is a chronic inflammatory disorder with limited topical treatment options and long-term corticosteroid dependency. This study investigates a novel atorvastatin-loaded hyalurosomal gel (ATV-Hyalugel) as a topical adj...
Targeted delivery of IFN-α-anti-GPC3 fusion protein via mRNA-LNP platform elicits potent anti-tumor immunity in hepatocellular carcinoma [0.03%]
基于mRNA-LNP平台的IFN-α-抗GPC3融合蛋白肝癌治疗中的靶向输送及其激发特异性抗肿瘤免疫应答的作用机制研究
Yajie Pan,Ruyue Chen,Xueyan Lv et al.
Yajie Pan et al.
This study aimed to utilize the mRNA-lipid nanoparticle (mRNA-LNP) platform to achieve in situ hepatic expression of an interferon-α (IFN-α)/anti-glypican-3 (anti-GPC3) fusion protein (GPA01), enhancing IFN-α targeting and antitumor acti...
Development of a microneedle patch for delivery of mRNA-lipid nanoparticles [0.03%]
一种递送脂质纳米颗粒mRNA的微针贴片的研发
Sophia H Sakers,B Pradeep K Reddy,Gianna Fiduccia et al.
Sophia H Sakers et al.
mRNA delivered by microneedle patch (MNP) can enable painless delivery, reduced need for healthcare expertise, and improved thermostability. In this study, we investigated formulation and manufacturing approaches for developing MNPs that de...
Delivery of monoclonal antibodies to the brain: the impact of nanocarrier structure [0.03%]
纳米载体结构对脑部单克隆抗体递送的影响
Laura Pineiro-Alonso,Inés Rubio-Prego,Ana M López-Estévez et al.
Laura Pineiro-Alonso et al.
Monoclonal antibodies (mAbs) are promising therapeutic agents for neurological disorders due to their high specificity. However, their clinical application is significantly hindered by their poor transport across the blood-brain barrier (BB...
Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson's disease treatment by intranasal administration [0.03%]
基于壳聚糖接枝多巴胺的多功能纳米药物递送系统用于鼻黏膜给药治疗帕金森病研究
Adriana Trapani,Annalucia Carbone,Sante Di Gioia et al.
Adriana Trapani et al.
The main aim of this work was to synthesize new chitosan amphiphilic derivatives able to self-assembly encapsulating substances acting at different target sites implicated in Parkinson disease (PD). For this purpose, O-carboxymethyl-chitosa...
Muscle-targeting LNP vaccines enable potent immune responses against varicella zoster virus [0.03%]
肌肉靶向LNP疫苗能够诱发针对水痘-带状疱疹病毒的强效免疫反应
Honglei Zhang,Jingxuan Ma,Lijie Jin et al.
Honglei Zhang et al.
Messenger RNA (mRNA) therapeutics have shown considerable promise across a wide range of medical applications with lipid nanoparticles (LNPs) emerging as the most clinically advanced mRNA delivery vehicles. However, the risk of off-target t...
Microneedle-mediated delivery of hydroxypropyl-β-cyclodextrin-encapsulated Angelica sinensis (Danggui) essential oil for acne treatment: efficacy and mechanisms [0.03%]
用于痤疮治疗的羟丙基-β-环糊精包封当归精油的微针递送：功效与机制研究
Xiaoli Liu,Xiaojuan Li,Weijun He et al.
Xiaoli Liu et al.
Acne is a multifactorial dermatological condition driven by Propionibacterium acnes (P. acnes) infection, inflammation, and sebum dysregulation. While essential oils, such as Angelica sinensis (Danggui) essential oil (AEO), exhibit antimicr...
Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template [0.03%]
植物辅助合成的嵌入交联玉米醇溶蛋白/海藻酸钠复合膜中的CuO纳米颗粒促进大鼠伤口愈合和组织再生生物模板
Sarah A El-Lakany,Nazik A Elgindy,Elbadawy A Kamoun et al.
Sarah A El-Lakany et al.
Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting method and superbly assisted by eco-friendly prepared copper oxide nanoparticles (CuO NPs). The influence of the addit...
Oral colon-targeted paeonol emulsion for ameliorating ulcerative colitis based on charge adsorption [0.03%]
基于电荷吸附的口服结肠靶向牡丹酚乳剂以改善溃疡性结肠炎
Lan Zhang,Xi Xiong,Weiwen Lu et al.
Lan Zhang et al.
Ulcerative colitis (UC), an inflammatory bowel disease, poses a severe threat to human health. Paeonol has demonstrated potential for the treatment of UC, particularly because of its remarkable anti-inflammatory properties. However, the hig...
Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery [0.03%]
带有偶氮苯守门者的介孔二氧化硅纳米粒子作为靶向阿霉素输送的低氧响应载药体系
Paula Rodrigo-Martínez,Mariana Barros,María Carmen Terencio et al.
Paula Rodrigo-Martínez et al.
Hypoxia is a key feature of solid tumors, contributing to therapeutic resistance and poor prognosis. Targeting hypoxic environments presents an opportunity to enhance drug delivery selectivity and improve treatment outcomes. Among nanocarri...