Temperature and osmotic pressure dual-stimuli-responsive ophthalmic gels embedded with HPCD-modified nanoparticles for prolonged-release delivery of natamycin [0.03%]
一种新型包涵体型纳米载药系统双刺激响应型温控释眼用凝胶给药体系用于延长纳他霉素作用时间研究
Bixia Lin,Fangfei Fan,Hui Xu et al.
Bixia Lin et al.
Fungal keratitis (FK) is a severe ocular disease that may cause blindness in severe cases. The only FDA-approved first-line treatment drug is natamycin (NAT). However, NAT bioavailability is less than 2% due to special environment of the ey...
A self-unfolding polymer foil loaded with a permeation enhancer Ionogel for superior oral peptide delivery [0.03%]
一种自展高分子膜加载透皮吸收促进剂离子凝胶的口腔多肽输送方法
Konstantinos Raptis,Reece McCabe,Marta Rubio-Huertas et al.
Konstantinos Raptis et al.
Peptide drugs have gained considerable attention as new molecular entities, due to their high target specificity. However, oral delivery of peptides remains a major challenge, and current formulation approaches typically achieve only low si...
Nanocomposite sublingual films: a scoping review of formulation trends and translational gaps [0.03%]
纳米复合亚 lingual 膜：制剂趋势和转化差距的综述性审查
Bárbara Felin Osmari,Marcel Henrique Marcondes Sari,Édina Regina Wichinheski et al.
Bárbara Felin Osmari et al.
Sublingual films are promising drug delivery platforms due to their rapid hydration and drug release, and the incorporation of nanoparticles can further improve drug solubility, bioavailability, and therapeutic efficacy. Therefore, this stu...
Fucoidan-based microneedle patch for delivery of IGF1-loaded exosomes in diabetic wound therapy [0.03%]
用于糖尿病伤口治疗的基于褐藻糖胶的微针贴片递送载IGF1外泌体
Marjan Mirhaj,Jaleh Varshosaz,Nada A Kadhim et al.
Marjan Mirhaj et al.
Diabetic wounds often lead to significant therapeutic challenges due to impaired vascularization, chronic inflammation, and poor drug penetration. This study presents a polyallylamine hydrochloride-fucoidan (PAH.Fc) hydrogel-based microneed...
Age outweighs route for AAV-PHP.eB transgene distribution via inner ear delivery [0.03%]
年龄而非途径决定AAV-PHP.eB转基因通过内耳递送的分布情况
Shuang Han,Yi Zhou,Honghai Tang et al.
Shuang Han et al.
Adeno-associated virus (AAV)-based gene therapy has demonstrated transformative potential in treating hereditary hearing loss (HHL). Investigating factors that influence AAV transduction in target and non-target organs is critical for impro...
Platelet membrane-fusing MSC-derived apoptotic extracellular vesicles enhanced cardiac repair after ischemia/reperfusion injury [0.03%]
血小板融合的脂肪干细胞源性凋亡微泡通过释放生物活性RNA促进缺血/再灌注心脏损伤修复
Zhifeng Song,Fangshun Tan,Yu Jiang et al.
Zhifeng Song et al.
Myocardial ischemia/reperfusion injury (I/RI) is a common complication following percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Mesenchymal stem cell-derived apoptotic vesicles (MSC-apoVs) seem ...
The closer, the better: intratumoral delivery of a thermoresponsive gemcitabine-loaded hydrogel in preclinical PDAC models [0.03%]
更近更好：在预临床PDAC模型中递送载有热响应吉西他滨的水凝胶
Andrea Vallés-Martí,Ajinkya Manelkar,Christopher R Simpson et al.
Andrea Vallés-Martí et al.
Current treatments for pancreatic ductal adenocarcinoma (PDAC) patients are typically restricted to (neo)adjuvant chemotherapy, surgery or palliative care. Mainly due to a late diagnosis and highly desmoplastic environment, these treatments...
E-selectin and transferrin receptor functionalized synthetic miRNA nanoshuttles with therapeutic potential in stroke [0.03%]
用于卒中治疗的携带功能性microRNA的合成纳米载体及其E-选择素和转铁蛋白受体修饰的功能化研究
Valérie Petegnief,Maria Kannavou,Valeria Peli et al.
Valérie Petegnief et al.
Current acute ischemic stroke treatment is limited to reperfusion therapies within the first hours after the onset, underscoring the urgent need for novel therapeutic strategies to mitigate the progression of the brain lesion. Here, we desc...
Predicting drug release from polymeric long-acting injectables using a machine learning approach to decode formulation-performance relationships [0.03%]
基于机器学习的解码配方性能关系预测聚合物长效注射剂药物释放量的研究
Tianqi Wang,Tianyu Liu,Xiaoying Xu et al.
Tianqi Wang et al.
Polymeric long-acting injectables (LAIs) are among the most impactful yet least predictable drug delivery systems, as their performance emerges from a widely unresolved combination of polymer microstructure, manufacturing history, and assay...
Targeted co-delivery of curcumin and TRAIL via engineered extracellular vesicles: a synergistic therapy against resistant cancers [0.03%]
工程化细胞外囊泡介导的姜黄素和TRAIL共递送协同抗肿瘤作用研究
Lang Liu,Jiahong Jiang,Zelin Wu et al.
Lang Liu et al.
Renal cell carcinoma (RCC) is a resistant malignancy with a rising global incidence, thereby highlighting an urgent need for innovative treatment strategies. Curcumin (CUR), a natural polyphenolic compound, is promising for cancer treatment...