An effort to enhance the clinical translatability of caprate-based tablet formulations in gastric peptide delivery [0.03%]
提高胃递送肽药物 капрат为基础的片剂 formulation的临床转化能力的一项研究
Pierre-Louis Bardonnet,Zhigao Niu,Jenni Pessi et al.
Pierre-Louis Bardonnet et al.
Sodium caprate (C10) is the most investigated permeation enhancer to promote oral peptide absorption. However, the clinical translation of C10-based formulations is possibly affected by low gastric pH. Here, we developed a C10-based immedia...
Bioavailability enhancement and neuropharmacological effects of Dauricine under intranasal administration to improve cognitive impairment via PI3K/AKT/mTOR pathway [0.03%]
高效传递的胆碱用于改善学习记忆损伤中的乙酰胆碱缺陷作用及机制研究
Ruiye Xie,Zhen Liu,Jingjing Zheng et al.
Ruiye Xie et al.
Alzheimer's disease (AD) is a neurodegenerative disorder strongly associated with aging, and Dauricine (DAU) has demonstrated significant neuropharmacological properties for AD treatment. However, its bioavailability is significantly limite...
Core-shell nanotherapeutics for diabetic cataract and retinopathy: current state-of-the-art and translational challenges [0.03%]
糖尿病白内障和视网膜病变的核壳纳米药物：现状与转化挑战
Gitika Kumari,Sourabh Kundu,Paras Famta et al.
Gitika Kumari et al.
Diabetes associated ocular complications, such as diabetic retinopathy (DR) and diabetic cataract (DC), constitute a substantial number of blind cases worldwide. Contemporary therapeutic interventions include intravitreal administration of ...
Precision engineering of macrophage reprogramming with RNA interference-loaded lipid nanoparticles: a game-changer in cancer immunotherapy [0.03%]
基于RNA干扰的脂质纳米颗粒精准重编程巨噬细胞：癌症免疫治疗中的游戏规则改变者
Sezen Gül,Juliette Vergnaud,François Fay et al.
Sezen Gül et al.
Tumor-associated macrophages (TAMs) represent solid tumors' most prevalent immune cell subset. These cells primarily adopt an immunosuppressive phenotype in the tumor microenvironment, promoting tumor initiation and progression. Their abili...
Toward a harmonized regulatory framework for 3D-printed pharmaceutical products: the role of critical feedstock materials and process parameters [0.03%]
面向药品3D打印的协调监管框架：原材料和工艺参数的作用
Riyad F Alzhrani,Rawan A Fitahi,Majed A Majrashi et al.
Riyad F Alzhrani et al.
The commercialization of additive manufacturing (AM) in pharmaceuticals manufacturing has attracted significant attention for its potential to produce customized products. However, the process is slow and hindered by the lack of designated ...
Image-guided in vivo evaluation and comparison of bone-targeting peptides for therapeutic intervention [0.03%]
基于影像引导的骨靶向肽类活体评价及比较研究
Austin Stellpflug,Amit Joshi,Shue Wang et al.
Austin Stellpflug et al.
Hydroxyapatite (HA)-binding peptides hold strong potential for bone-targeted therapies due to their high affinity for mineralized tissues. However, most existing studies have primarily focused on in vitro binding characterization, offering ...
Correction: Neratinib-loaded solid lipid nanoparticles in dissolvable microneedles for enhanced transdermal breast cancer therapy [0.03%]
纠正：用于增强透皮乳腺癌治疗的纳拉替尼固体脂质纳米粒可溶性微针递送系统
Saraisam Kishor Kumar Singha,Venkatesh Dinnekere Puttegowda,Yousef Al-Ebini et al.
Saraisam Kishor Kumar Singha et al.
Published Erratum
Drug delivery and translational research. 2025 Sep 12. DOI:10.1007/s13346-025-01969-8 2025
Application and development prospects of bio-based smart responsive hydrogels in insulin delivery [0.03%]
生物刺激响应性水凝胶的胰岛素递送应用及发展前景研究
Huijuan Su,Xiaolian Chen,Dongyi Huang et al.
Huijuan Su et al.
The increasing prevalence of diabetes has made insulin formulations a cornerstone in the management of the disease. However, traditional insulin delivery methods, such as subcutaneous and intravenous injections, face several challenges, inc...
Hanging drop culture reprograms mesenchymal stem cell transcriptome to enhance cell delivery efficiency via attenuated pulmonary entrapment [0.03%]
悬挂滴培养可重编间充质干细胞转录组以增强细胞递送效率并减弱肺部滞留
Hsiang-Tzu Lee,Sheng-Yung Fu,Wei-Han Weng et al.
Hsiang-Tzu Lee et al.
The three-dimensional (3D) culture system has emerged as an indispensable platform for modulating stem cell function in biomedicine, drug screening, and cell therapy. Despite a few studies confirming the functionality of 3D culture, the mol...
Current status of Liraglutide delivery systems for the management of type 2 diabetes mellitus [0.03%]
利拉鲁肽给药系统治疗2型糖尿病的最新研究进展
Riti Chatterjee,Vishal Sangita Babasaheb Galave,Anil B Jindal
Riti Chatterjee
Diabetes is a metabolic disorder of increasing global concern. Characterized by constantly elevated levels of glucose, severe β-cell dysfunction, and insulin resistance, it is the cause of a major burden on patients if not managed with the...