Ex vivo validation of osteogenic efficacy in a bioceramic dual drug-delivery system [0.03%]
一种生物陶瓷骨组织药物传输系统的体外有效性验证研究
Miguel A Rodrigues,Liliana Grenho,Rita Araújo et al.
Miguel A Rodrigues et al.
Alendronate (ALN) is widely employed against skeletal disorders, but its low oral bioavailability and prolonged skeletal retention necessitate high systemic doses that carry significant risk. The research team previously developed a novel b...
Correction: Toward a harmonized regulatory framework for 3D-printed pharmaceutical products: the role of critical feedstock materials and process parameters [0.03%]
关于3D打印药物产品的监管框架的协调：关键原材料和工艺参数的作用的更正通知
Riyad Alzhrani,Rawan A Fitaihi,Majed A Majrashi et al.
Riyad Alzhrani et al.
Published Erratum
Drug delivery and translational research. 2025 Oct 20. DOI:10.1007/s13346-025-02000-w 2025
Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption [0.03%]
视网膜内界膜破裂后的脂质纳米颗粒设计决定递送效果
Kaat De Clerck,Emma De Coster,Luca Paoletti et al.
Kaat De Clerck et al.
The interest in lipid nanoparticle (LNP)-mediated mRNA delivery significantly accelerated in the aftermath of the clinical success of mRNA-based COVID-19 vaccines. Validated as an effective and scalable platform, LNPs are now considered a c...
Localized co-delivery of in-situ hydrogel containing ibrutinib-PLGA-PEG-folate nanoparticle and octreotide microsphere to glioblastoma [0.03%]
负载Ibrutinib-PLGA-PEG-叶酸纳米粒和奥曲肽微球的原位水凝胶局部协同递送体系治疗胶质母细胞瘤
Bahar Morshedi,Mehdi Esfandyari-Manesh,Mohammad Hossein Ghahremani et al.
Bahar Morshedi et al.
Glioblastoma (GBM), a grade IV astrocytoma, is defined by its rapid proliferation, strong infiltrative nature, resistance to chemotherapy, and tendency to recur quickly, even after surgery and standard treatments. We hypothesize that the lo...
Preliminary study on targeted therapy of breast cancer using tumor cell membrane-coated dual-loaded liposomes based on chemo-photothermal synergistic effects [0.03%]
基于化疗和光热协同效应的乳腺癌细胞膜包被载药脂质体的靶向治疗研究初步报告
Yuwei Wang,Shuchao Pang,Yun Lu et al.
Yuwei Wang et al.
Addressing the clinical challenges of lacking effective therapeutic targets and the high recurrence rate in triple-negative breast cancer (TNBC), this study innovatively constructed a targeted nanoplatform (CM@DOX-GO NPs) based on the syner...
Rapid dissolving microneedle patch integrated with benidipine-loaded nanotransfersomes for transdermal drug delivery: optimization, characterizations, and preclinical bioavailability assessment [0.03%]
一种快速溶解的微针贴片通过载有苯那普利纳米转移体实现透皮给药：优化、表征及药物生物利用度评估
Khater Al-Japairai,Samah Hamed Almurisi,Fawaz Alheibshy et al.
Khater Al-Japairai et al.
Benidipine hydrochloride (BEN) is widely prescribed for managing hypertension; however, its clinical efficacy is limited by poor oral bioavailability. This study introduces an innovative delivery approach, incorporating BEN-loaded nanotrans...
Electron paramagnetic resonance (EPR) meets drug delivery and biomaterials: a magnetic love story [0.03%]
电子顺磁共振与药物输送及生物材料：一段磁性爱情故事
Bernard Gallez
Bernard Gallez
This narrative review underscores the powerful role of Electron Paramagnetic Resonance (EPR), also known as Electron Spin Resonance (ESR), in characterizing drug delivery systems (DDSs). Using drugs or probes tagged with spin labels, EPR pr...
Engineering a nifurtimox nanosuspension: toward improved pharmaceutical attributes [0.03%]
一种硝呋莫司纳米悬浮制剂的开发：改善其药剂学属性
María Sol Magi,Lucía Lopez-Vidal,Mónica Cristina García et al.
María Sol Magi et al.
Nifurtimox (NFX) is one of the two approved drugs for the treatment of Chagas disease, a neglected parasitic infection caused by Trypanosoma cruzi. Classified as a biopharmaceutics classification system class II/IV drug, NFX exhibits poor a...
Nanoemulsion as a promising drug delivery strategy for effective eradication of Helicobacter pylori: current insights [0.03%]
纳米乳液作为有效根除幽门螺旋杆菌的药物递送策略的最新见解
Moumita Saha,Ashutosh Gupta,Shivani Kunkalienkar et al.
Moumita Saha et al.
Helicobacter pylori (H. pylori) have infected about 50% of the world's population and is a leading cause of gastrointestinal diseases, including gastritis, peptic ulcer, and stomach cancer. Current treatment regimens often fail to completel...
From simulation to application: enhancing preclinical evaluation of dissolvable microarray patches through PBPK modelling [0.03%]
从模拟到应用：通过PBPK建模增强可溶解微阵列贴片的临床前评估
Maja Railic,Wilhelmus E A de Witte,Stephan Schaller et al.
Maja Railic et al.
Dissolvable microarray patches (MAP) represent a promising drug delivery platform; however, the absence of standardised protocols for their preclinical evaluation poses a significant barrier to regulatory approval and clinical translation. ...