Design and preparation of novel domperidone loaded polymeric blend electrospun nanofibers for improved oral pharmacodynamic activity [0.03%]
一种新型多潘立酮载药聚合物共混纳米纤维的设计制备及其对口服药动学的改善作用研究
Kamal Shatla,Eman Sweed,Suleiman Eltokhy et al.
Kamal Shatla et al.
Domperidone (DOM) is a BCS class II drug which widely used as an oral medication for the control of nausea and vomiting. It showed a very low and variable bioavailability related to its very poor solubility and pre-systemic metabolism. Poly...
Surface decoration of solid lipid nanoparticles with cyclic RGD peptides for precision therapy in high-risk neuroblastoma [0.03%]
环状RGD肽修饰的固脂纳米粒用于高危型神经母细胞瘤的精准治疗
Sara Lorenzoni,Carlos Aydillo,Carlos Rodríguez-Nogales et al.
Sara Lorenzoni et al.
High-risk neuroblastoma poses significant therapeutic challenges due to tumor heterogeneity, drug resistance, and systemic toxicity associated with conventional chemotherapies. To overcome these limitations, we developed cyclic RGD-decorate...
Optimization of print parameters for batch and continuous manufacturing of three-dimensional (3D) printed dosage forms using artificial intelligence and machine learning [0.03%]
基于人工智能和机器学习的三维(3D)打印剂型批次和连续生产的印刷参数优化
Kshitij Chitnis,Yizhou Lu,Benjamin Rhoads et al.
Kshitij Chitnis et al.
Three-dimensional printing (3DP) holds significant potential for developing personalized pharmaceutical oral dosage forms (printlets). 3D printing has the advantage of fabricating complex geometric structures for versatile drug release prof...
Biodegradable microneedles for transdermal sitagliptin delivery: in vivo insights into enhanced diabetes management [0.03%]
用于经皮递送西他列汀的可生物降解微针：增强糖尿病管理的体内研究见解
Rania M Yehia,Muhammed Ossama,Ghada H Elosaily et al.
Rania M Yehia et al.
Dynamic 3D microfluidic platform for exploring combined targeted therapy, chemotherapy, and virotherapy delivery in ovarian cancer [0.03%]
用于探索卵巢癌联合靶向治疗、化疗和病毒治疗递送的动态三维微流控平台
Lukasz Kuryk,Sara Mathlouthi,Lisa Casagrande et al.
Lukasz Kuryk et al.
Ovarian cancer poses a persistent therapeutic challenge due to late-stage diagnosis, frequent relapse, and resistance to standard therapies. While oncolytic viruses (OVs) offer a promising immunotherapeutic approach, their clinical efficacy...
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs [0.03%]
利用量子化学性质进行迁移学习以预测药物的血脑屏障通透性
Megan A Lim,Marybeth G Yonk,Kimberly B Hoang et al.
Megan A Lim et al.
The blood-brain barrier (BBB), crucial for central nervous system (CNS) homeostasis, poses challenges for drug delivery in CNS diseases due to selective permeability. Because of this difficulty, there are limited treatments developed for CN...
Thermosensitive in situ gel powered by pectin-chitosan nanocapsules for intraocular delivery of acetazolamide: in vitro, ex vivo, and in vivo evaluation [0.03%]
一种新型壳聚糖-果胶纳米缓释系统用于青光眼治疗药物的玻璃体内给药：体外、离体及活体研究
Uddhav Bagul,Shubham Khot,Ashish Monde et al.
Uddhav Bagul et al.
The current study aimed at development of acetazolamide loaded pectin-chitosan nanocapsules (APCNC) via a polyelectrolyte complex coacervation technique, further incorporated into a poloxamer 407 and HPMC-based in situ gel (APCNC-ISG). The ...
Local delivery of Doxorubicin and Olaparib loaded injectable hydrogels with adjuvant radiotherapy improves survival in a glioblastoma in vivo model [0.03%]
载有多柔比星和奥拉帕尼的可注射水凝胶局部递送并辅以放疗改善了异种移植胶质母细胞瘤模型小鼠的生存率
Robert Cavanagh,Gary Shaw,Phoebe McCrorie et al.
Robert Cavanagh et al.
Local drug delivery systems (LDDS) are a promising method to overcome challenges associated with chemotherapeutic treatment of brain tumours, namely poor blood-brain barrier penetration. Here we report a poly(ethyleneglycol)-poly(lactide)-p...
Bioorthogonal liposome-based sequential drug delivery system for enhanced tumor accumulation and targeted therapy [0.03%]
一种用于增强肿瘤蓄积和靶向治疗的生物正交脂质体介导的序贯药物递送系统
Yang Wang,Wen Zheng,Junjie Yan et al.
Yang Wang et al.
Effective drug accumulation at tumor sites remains a critical challenge in cancer therapy due to poor targeting and off-target effects. This study leverages bioorthogonal chemistry to develop a novel liposome-based drug delivery system desi...
Assessment of AAV/polyketal chimeric nanoparticles for ocular gene transduction using an animal model [0.03%]
利用动物模型评估AAV/聚乙二醇共价交联纳米颗粒的视网膜基因转导能力
Brenda Fernanda Moreira Castro,Margareth Lugin,Maria Carolina Andrade Guerra et al.
Brenda Fernanda Moreira Castro et al.
Gene therapy has made significant progress in ophthalmology in recent years, particularly through adeno-associated virus (AAV)-mediated delivery. Despite well-known advantages of AAV vectors, their restricted cargo capacity, immunogenicity,...