Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications [0.03%]
作为多功能分子的依来因：生产及药用价值探索
Patrícia Ferreira,Janaína Artem Ataide,Soraya Babaie et al.
Patrícia Ferreira et al.
Traditional topical therapies can have considerable side effects, leading to the research for natural and biocompatible alternatives. Ectoine, a natural osmolyte produced by extremophilic microorganisms, possesses an extraordinary ability t...
Comparative review of translational approaches in lipid-based and water-based encapsulation strategies for coenzyme Q10 [0.03%]
用于辅酶Q10脂质基和水基包封策略的翻译方法综述研究
Norhamiza Mohamad Sukri,Nadirah Abd Rahim,Hesham Ali El Enshasy et al.
Norhamiza Mohamad Sukri et al.
The global coenzyme Q10 (CoQ10) market is expanding, driven by the increasing prevalence of chronic diseases, particularly cardiovascular disorders. Forecasts project a compound annual growth rate of 9.68% from 2025 to 2034. Despite its cri...
Combining Leu-enkephalin nanomedicines with enkephalinase inhibitors: a promising painkiller strategy? [0.03%]
白细胞脑啡肽纳米药物与阿片梅脱酶抑制剂联用：有前景的止痛策略？
Lucas Prades,Hadjer Hazam,Frédéric Gobeaux et al.
Lucas Prades et al.
This study investigates the potential of a novel nanomedicine approach relying on squalene nanoparticles of endogenous enkephalinase inhibitors (EEI) - opiorphin (OPN) and STR-324 - to alleviate pain by potentiating the action of enkephalin...
Functional polysaccharide-based bioactive delivery systems for urinary and reproductive system therapeutics [0.03%]
用于泌尿生殖系统药物的基于功能性多糖的生物活性递送系统
Yung-Wei Lin,Lekshmi Rethi,Wen-Yu Pan et al.
Yung-Wei Lin et al.
Damage to lower genitourinary (GU) organs, which can lead to organ dysfunction and/or infertility, poses a significant threat to individual health and quality of life. Polysaccharide-based delivery systems for biologically active therapeuti...
Formulation and evaluation of probucol-LCA nanoparticles for supressing oxidative stress-related retinal degeneration [0.03%]
普布考尔-LCA纳米粒的制备及其抑制氧化应激相关视网膜变性的评价研究
Susbin Raj Wagle,Alicia Brunet,Rebekah James et al.
Susbin Raj Wagle et al.
Retinal degenerative diseases are a major cause of vision loss worldwide, with oxidative stress being a key pathological driver. This study aimed to develop and evaluate probucol-lithocholic acid (LCA) nanoparticles for targeted retinal pro...
Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases [0.03%]
双药共封装到脂质体和脂质体衍生的纳米系统中，以改善皮肤疾病的协同治疗效果
Sara Rodrigues,Francisco Veiga,Ana Cláudia Paiva-Santos et al.
Sara Rodrigues et al.
Skin disorders impact nearly one-third of the global population, and represent the fourth most common cause of human diseases. However, delivering drugs into and through the skin is a significant challenge due to its low permeability, which...
CEB-01 membrane loaded with SN-38 for local post-resection control and metastasis reduction in preclinical pancreatic cancer models [0.03%]
负载SN-38的CEB-01膜用于局部手术后控制和减少预临床胰腺癌模型中的转移
Anna Huguet Ninou,Pablo Caruana,Luc Marti et al.
Anna Huguet Ninou et al.
Pancreatic cancer (PC) is an aggressive malignancy with extremely poor prognosis, in which resection surgery remains the only therapeutic option with curative intent. Patients often present with locoregional metastases in lymph nodes, perit...
Development, in silico, in vitro, and in vivo evaluation of gatiserts: HME-based ophthalmic inserts for prolonged ocular delivery of gatifloxacin [0.03%]
基于HME的氧氟沙星眼用插入剂给药系统的设计、开发及评价
Amit Sharma,Santosh Kumar Behera,Jourawar Singh et al.
Amit Sharma et al.
The objective of this study was to develop and characterize hot-melt extrusion (HME)-based gatifloxacin-loaded ophthalmic inserts (Gatiserts) to enhance ocular retention and reduce dosing frequency for bacterial conjunctivitis management. G...
Development and evaluation of recombinant Varicella-Zoster virus glycoprotein E protein microneedles for enhanced pediatric vaccine delivery [0.03%]
用于改善儿童疫苗输送的重组水痘带状疱疹病毒糖蛋白E微针的开发与评价
Da-Eun Lee,Hye-Ran Cha,Ye-Lim Lee et al.
Da-Eun Lee et al.
Varicella-zoster virus (VZV) infection remains a significant pediatric health concern, and current live-attenuated vaccines are limited by cold-chain requirements, reactivation risk, and injection-related anxiety. To address these challenge...
Novel voriconazole-loaded hyalurosomes optimized for enhanced skin penetration and antifungal activity against Candida albicans [0.03%]
一种新型载伏立康唑透明质酸囊泡用于优化皮肤渗透及抗白色念珠菌活性的研究
Amparo Nácher,José-Esteban Peris,Raquel Taléns-Visconti et al.
Amparo Nácher et al.
Cutaneous candidiasis, mainly caused by Candida albicans, is a growing global health concern and is listed by WHO as a high-priority fungal threat. Suboptimal penetration of conventional vehicles limits the efficacy of current topical antif...