Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors [0.03%]
角鲨烯B脂质体递送的功能及对 Hedgehog 依赖型肿瘤的治疗效果
Paola Infante,Raffaella Daniele,Marta Bottero et al.
Paola Infante et al.
Aberrant Hedgehog (HH) signaling pathway is responsible of tumorigenesis of medulloblastoma (MB) and basal cell carcinoma (BCC), two aggressive malignancies with limited therapeutic options. Targeting Gli1, the final and powerful effector o...
Adenosine and guanosine-based oligonucleotides-loaded PLGA nanoparticles attenuates progression of surgically induced osteoarthritis [0.03%]
基于腺苷和鸟苷的寡核苷酸载药PLGA纳米颗粒抑制术后骨关节炎进展
Yoonhee Kim,Jin Han,Ji Young Park et al.
Yoonhee Kim et al.
Osteoarthritis (OA) is a chronic degenerative joint disease that lacks effective therapies to halt its progression. While endogenous purinergic signaling-particularly via adenosine-shows promise for reducing inflammation, it is limited by s...
Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis [0.03%]
用于真菌性角膜炎治疗的伏立康唑纳米悬浮液眼用双层溶解型microneedles贴片
B H Jaswanth Gowda,Anjali K Pandya,Shilpkala Gade et al.
B H Jaswanth Gowda et al.
Fungal keratitis (FK), caused by fungi like Aspergillus, Fusarium, and Candida, accounts for 20-60% of microbial keratitis cases and over 1 million visual impairments annually. Voriconazole (VOR) is effective against FK, but its eye drop fo...
Formulation and characterization of exenatide-loaded PLGA microspheres prepared by coacervation [0.03%]
通过共沉淀法制备并表征西格列汀载药PLGA微球
Cameron White,Steven P Schwendeman
Cameron White
Bydureon® is a once-weekly injection of poly(lactide-co-glycolide) (PLGA) microspheres containing exenatide acetate, a synthetic analog of the GLP-1 receptor agonist exendin-4. These microspheres are formulated by coacervation (i.e., phase...
Oromucosal films for peptide delivery: formulation strategies using permeation enhancers and polymers [0.03%]
用于肽递送的口服黏膜给药片剂：使用透皮吸收促进剂和聚合物的配方策略
Sandeep Karki,Sahil Malhotra,Muhammad Ijaz et al.
Sandeep Karki et al.
Buccal and sublingual mucosae offer highly vascularized, patient-acceptable routes for systemic peptide delivery, providing a promising alternative to peptide injections and conventional oral peptide dosage forms that suffer from enzymatic ...
Nanocarrier-based intranasal drug delivery for enhanced neurological disorders treatment [0.03%]
基于纳米载体的鼻内药物递送系统在神经系统疾病治疗中的应用
Eva Morim,Bruno Sarmento,Catarina Pacheco
Eva Morim
The blood-brain barrier (BBB) represents a major obstacle in the treatment of neurological disorders. While it plays a crucial role in protecting the central nervous system (CNS) from harmful xenobiotics, it also limits the entry of drugs a...
Precision engineering of anti-atherosclerotic herbal nanomedicine: from machine learning-aided active components screening to optimized metal-phenolic network codelivery [0.03%]
抗动脉粥样硬化中药纳米医药的精密工程：从机器学习辅助活性成分筛选到优化金属酚网络协同递送
Yao Chen,Meiting Lu,Lu Zhang et al.
Yao Chen et al.
Atherosclerosis (AS), a chronic inflammatory disease linked to oxidative stress and lipid imbalance, remains a major cardiovascular threat. Traditional herbs Salvia miltiorrhiza and Carthamus tinctorius exhibit multi-target anti-AS potentia...
Smart nanocarriers in triple-negative breast cancer: recent advances in targeting and translational application [0.03%]
智能纳米载体在三阴性乳腺癌中的研究进展：靶向作用及转化应用
Aparana Mishra,Vitthal L Gole,Smriti Ojha
Aparana Mishra
Breast cancer remains one of the most prevalent causes of cancer-related mortality worldwide. Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that has a poor prognosis and limited therapeutic options. Smart...
Novel crystalline solid dispersions to improve the oral bioavailability and anti-liver cancer effect of Sorafenib [0.03%]
一种新型晶体固态分散体以提高索拉非尼口服生物利用度及抗肝癌效应研究
Yong Zhang,Yujin Wang,Baihui Gong et al.
Yong Zhang et al.
This study investigates the interrelationships among drug loading, steric hindrance (Sh), defined as the spatial constraints imposed by the crystallized polymer network that physically restrict drug crystal growth, effective glass transitio...
Development of sustained release injectable phospholipid-based phase transition gel matrixed with Piracetam and cannabidiol loaded nanoemulsion for amelioration of Alzheimer's therapy [0.03%]
开发用于改善阿尔茨海默氏症治疗的持续释放注射用含磷脂基相变凝胶负载ピラセタム和大麻二酚纳米乳剂矩阵的研究
Mohd Shahrukh,Mohammad Adil,Nazeer Hasan et al.
Mohd Shahrukh et al.
Alzheimer's disease (AD) is an incurable neurological disorder and the primary cause of dementia globally, yet therapeutic options remain limited by poor drug efficacy, low patient adherence, and the restrictive blood-brain barrier (BBB), w...