Recent advances in porous microneedles: materials, fabrication, and transdermal applications [0.03%]
用于透皮给药的微针最新进展：材料、制备和跨皮应用
Leilei Bao,Jongho Park,Gwenaël Bonfante et al.
Leilei Bao et al.
In the past two decades, microneedles (MNs), as a painless and simple drug delivery system, have received increasing attention for various biomedical applications such as transdermal drug delivery, interstitial fluid (ISF) extraction, and b...
Jing Sun,Jennifer Walker,Moritz Beck-Broichsitter et al.
Jing Sun et al.
Poly(lactic-co-glycolic acid) (PLGA) is among the most common of biodegradable polymers studied in various biomedical applications such as drug delivery and tissue engineering. To facilitate the understanding of the often overlooked impact ...
Biomaterial-based immunotherapeutic strategies for rheumatoid arthritis [0.03%]
基于生物材料的治疗类风湿关节炎免疫疗法策略
Allen B Tu,Jamal S Lewis
Allen B Tu
Rheumatoid arthritis (RA) is an extremely painful autoimmune disease characterized by chronic joint inflammation leading to the erosion of adjacent cartilage and bone. Rheumatoid arthritis pathology is primarily driven by inappropriate infi...
Tailoring drug co-delivery nanosystem for mitigating U-87 stem cells drug resistance [0.03%]
用于克服U-87肿瘤干细胞耐药性的药物共输送纳米系统及其设计
Amir Barzegar Behrooz,Reza Vazifehmand,Asilah Ahmad Tajudin et al.
Amir Barzegar Behrooz et al.
Glioblastoma multiforme (GBM) is the most prevalent form of brain tumor, which generally has a poor prognosis. According to consensus, recurrence of the tumor and chemotherapy resistance acquisition are the two distinguishing features of GB...
Sepideh Nezhadi,Farid Abedin Dorkoosh
Sepideh Nezhadi
Cancer is a multidimensional and challenging disease to handle. Current statistics reveal that we are far from satisfying cancer treatment. Taking advantage of different therapeutic agents that affect multiple pathways has been established ...
In vitro dissolution testing models of ocular implants for posterior segment drug delivery [0.03%]
后段递药的眼用植入给药装置的体外释放试验模型研究
Muhammad Faris Adrianto,Febri Annuryanti,Clive G Wilson et al.
Muhammad Faris Adrianto et al.
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the...
Rational combination of an immune checkpoint inhibitor with CSF1R inhibitor-loaded nanoparticle enhances anticancer efficacy [0.03%]
合理联合使用免疫检查点抑制剂和CSF1R抑制剂载药纳米颗粒可增强抗癌疗效
Anujan Ramesh,Vaishali Malik,Hayat Anu Ranjani et al.
Anujan Ramesh et al.
Since the advent of immune checkpoint inhibitors, rapid strides have been made in the realm of cancer immunotherapy. Of the abundance of infiltrating immune cells in the tumor microenvironment (TME), macrophages contribute a significant por...
Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases [0.03%]
外泌体作为细胞来源载体在中枢神经系统疾病诊断和治疗中的应用
Gayatri Gopal Shetgaonkar,Shirleen Miriam Marques,Cleona E M DCruz et al.
Gayatri Gopal Shetgaonkar et al.
Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, ...
Seung Woo Chung,Yunxuan Xie,Jung Soo Suk
Seung Woo Chung
Immunotherapy has emerged as an unprecedented hope for the treatment of notoriously refractory cancers. Numerous investigational drugs and immunotherapy-including combination regimens are under preclinical and clinical investigation. Howeve...
Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting [0.03%]
结合肿瘤趋向和渗透肽结构域的分子杂交体用于细胞靶向定位
Ruchika Goyal,Gaurav Jerath,Aneesh Chandrasekharan et al.
Ruchika Goyal et al.
A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular up...