Dissolving microneedles incorporating kopexil multicomponent crystals for improved transdermal delivery [0.03%]
用于改善经皮给药的kopexil多组分晶体溶解型微针
Yuehua Deng,Si Nga Wong,Wing Chi Nico Chan et al.
Yuehua Deng et al.
Notwithstanding the rapid advancements in microneedle research, the applications of multicomponent crystals (MCCs) within microneedle drug delivery landscape remain largely underexplored. This study aimed at integrating crystal engineering ...
Overcoming size barriers in retinal gene therapy via lipid nanoparticle-mediated delivery of full-length eys DNA [0.03%]
基于脂质纳米颗粒的全长度EYS基因递送眼内注射治疗遗传性视网膜疾病的临床前研究
Sarah Goddaer,Emma De Coster,Elise Callens et al.
Sarah Goddaer et al.
Gene augmentation for inherited retinal diseases (IRDs) is constrained by the limited packaging capacity of viral vectors, rendering large genes such as EYS inaccessible to conventional delivery platforms. Here, we demonstrate a non-viral l...
Stimuli-responsive nanocarriers for targeted mRNA therapeutics: a paradigm shift in mRNA delivery for biomedical applications [0.03%]
用于靶向mRNA治疗的刺激响应型纳米递送载体：生物医学应用中mRNA递送的新范式
Nandita Yadav,Nitai Debnath,Sumistha Das
Nandita Yadav
Messenger RNA (mRNA) based therapeutics have emerged as a transformative modality with immense potential for treating infectious diseases, cancer, genetic disorders, and other complex conditions. Despite their promise, clinical translation ...
Clinical translation of injectable hydrogels: from bioactive polymers to long-acting drug delivery systems [0.03%]
注射型水凝胶的临床转化研究：从中活性聚合物到长效药物输送系统
Natalia Carballo-Pedrares,Virna Margarita Martín Giménez,María José Alonso
Natalia Carballo-Pedrares
Injectable hydrogels (IHs) have emerged as versatile biomaterials that enable localized therapy through minimally invasive delivery. Their in situ sol-gel transition supports sustained and targeted release of therapeutics, enhancing patient...
Localized doxycycline delivery via polymeric nanoparticles anchored to electrospun PCL microfiber patch for MMP-2 inhibition in abdominal aortic aneurysm [0.03%]
腹主动脉瘤中通过静电纺PCL微纤维贴片锚定的聚合物纳米颗粒递送多西环素实现基质金属蛋白酶-2抑制的局部给药研究
Carles Bofill-Bonet,Germán Febas,Margalida Artigues et al.
Carles Bofill-Bonet et al.
Doxycycline (DOXY) is a well-established antibiotic that has recently shown potential in inhibiting matrix metalloproteinase-2 (MMP-2), a key enzyme involved in the progression of abdominal aortic aneurysms (AAA). However, the controlled de...
Correction: Assessment of AAV/polyketal chimeric nanoparticles for ocular gene transduction using an animal model [0.03%]
关于评估AAV/聚缩醛杂合纳米颗粒眼科基因转导的动物模型纠正公告
Brenda Fernanda Moreira Castro,Margaret Lugin,Maria Carolina Andrade Guerra et al.
Brenda Fernanda Moreira Castro et al.
Published Erratum
Drug delivery and translational research. 2026 Jan 16. DOI:10.1007/s13346-026-02048-2 2026
3D-Printed gelatin patches for topical delivery of niacinamide and vitamin A: Bridging microstructure, in vitro release, and in vivo penetration [0.03%]
用于局部递送烟酸酰胺和维生素A的3D打印明胶补片：结合微观结构、体外释放和体内渗透
Sara Bom,Pedro Prazeres,Pedro Contreiras Pinto et al.
Sara Bom et al.
The development of advanced topical delivery systems that enhance skin penetration and ensure controlled release of bioactives is a key focus in pharmaceutical research. Semi-solid extrusion 3D printing (SSE-3DP) has emerged as a versatile ...
A novel murine model of LITT for glioblastoma reveals tumor reduction, BBB permeabilization, and drug delivery via ThermoDox® [0.03%]
一项针对胶质母细胞瘤的新颖的啮齿动物LITT模型显示了肿瘤减少、BBB渗透以及通过ThermoDox进行药物输送
Prazwal Athukuri,Karina Moreno,Malcolm F McDonald et al.
Prazwal Athukuri et al.
Laser interstitial thermal therapy (LITT) is a minimally invasive treatment for brain tumors that are recurrent or surgically inaccessible. We developed a murine model of LITT to investigate its effects on tumor burden, immune activation, a...
Genistein-loaded solid lipid nanoparticle in microneedle patch: potential for enhanced management of osteoporosis [0.03%]
金雀异黄素固体脂质纳米粒微针贴片的抗骨质疏松研究及其增效机制探讨
Shama Shetty,Jobin Jose,Gopika Gopan et al.
Shama Shetty et al.
Microneedle patches, which are minimally invasive and have high patient compliance, offer a potential alternative for transdermal drug delivery, particularly in chronic diseases such as osteoporosis, which require consistent long-term thera...
Assessment of microneedle array insertion into skin using Raman spectroscopic techniques [0.03%]
拉曼光谱技术在评价皮肤微针插入中的应用
Rezvan Jamaledin,Panagiota Zarmpi,Adrián M Alambiaga-Caravaca et al.
Rezvan Jamaledin et al.
Microneedle (MN) arrays bypass the skin's stratum corneum barrier to deliver drugs directly into the viable tissue. The skin disposition of three types of MNs-dissolvable, degradable and hydrogel-forming, fabricated using different polymers...