Chaperonin GroEL uses asymmetric and symmetric reaction cycles in response to the concentration of non-native substrate proteins [0.03%]
分子浓度门控的对称与非对称循环——GroEL/ES协同促进底物折叠的新机制研究
Ryo Iizuka,Takashi Funatsu
Ryo Iizuka
The Escherichia coli chaperonin GroEL is an essential molecular chaperone that mediates protein folding in association with its cofactor, GroES. It is widely accepted that GroEL alternates the GroES-sealed folding-active rings during the re...
A unified statistical model of protein multiple sequence alignment integrating direct coupling and insertions [0.03%]
一种蛋白质多重序列比对的统一统计模型，结合直接耦合和插入事件
Akira R Kinjo
Akira R Kinjo
The multiple sequence alignment (MSA) of a protein family provides a wealth of information in terms of the conservation pattern of amino acid residues not only at each alignment site but also between distant sites. In order to statistically...
Operating principles of rotary molecular motors: differences between F1 and V1 motors [0.03%]
旋转分子马达的操作原理：F1与V1马达的不同点
Ichiro Yamato,Yoshimi Kakinuma,Takeshi Murata
Ichiro Yamato
Among the many types of bioenergy-transducing machineries, F- and V-ATPases are unique bio- and nano-molecular rotary motors. The rotational catalysis of F1-ATPase has been investigated in detail, and molecular mechanisms have been proposed...
Density functional study of molecular interactions in secondary structures of proteins [0.03%]
蛋白质二级结构分子间相互作用的密度泛函研究
Yu Takano,Ayumi Kusaka,Haruki Nakamura
Yu Takano
Proteins play diverse and vital roles in biology, which are dominated by their three-dimensional structures. The three-dimensional structure of a protein determines its functions and chemical properties. Protein secondary structures, includ...
Genetic analysis of revertants isolated from the rod-fragile fliF mutant of Salmonella [0.03%]
来自大肠杆菌短链脆性突变株fliF的回复突变体的遗传分析
Hitomi Komatsu,Fumio Hayashi,Masahiro Sasa et al.
Hitomi Komatsu et al.
FliF is the protein comprising the MS-ring of the bacterial flagellar basal body, which is the base for the assembly of flagellar axial structures. From a fliF mutant that easily releases the rod-hook-filament in viscous environments, more ...
Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains [0.03%]
SOS膜结合结构域的协同作用使RAS活化的正反馈相互转换
Yuki Nakamura,Kayo Hibino,Toshio Yanagida et al.
Yuki Nakamura et al.
Son of sevenless (SOS) is a guanine nucleotide exchange factor that regulates cell behavior by activating the small GTPase RAS. Recent in vitro studies have suggested that an interaction between SOS and the GTP-bound active form of RAS gene...
Structures of the troponin core domain containing the cardiomyopathy-causing mutants studied by small-angle X-ray scattering [0.03%]
用于研究心肌病致病突变体的原络肽核心结构域的小角X射线散射结构研究
Tatsuhito Matsuo,Soichi Takeda,Toshiro Oda et al.
Tatsuhito Matsuo et al.
Troponin (Tn), consisting of three subunits, TnC, TnI, and TnT, is a protein in the thin filaments in muscle, and, together with another thin-filament protein tropomyosin (Tm), plays a major role in regulation of muscle contraction. Various...
Daichi Yamada,Tatsuya Iwata,Junpei Yamamoto et al.
Daichi Yamada et al.
Photolyases (PHRs) are DNA repair enzymes that revert UV-induced photoproducts, either cyclobutane pyrimidine dimers (CPD) or (6-4) photoproducts (PPs), into normal bases to maintain genetic integrity. (6-4) PHR must catalyze not only coval...
Analysis of water channels by molecular dynamics simulation of heterotetrameric sarcosine oxidase [0.03%]
分子动力学模拟异四聚体甜菜碱脱氢酶通道分析
Go Watanabe,Daisuke Nakajima,Akinori Hiroshima et al.
Go Watanabe et al.
A precise 100-ns molecular dynamics simulation in aquo was performed for the heterotetrameric sarcosine oxidase bound with a substrate analogue, dimethylglycine. The spatial region including the protein was divided into small rectangular ce...
Microbial rhodopsins: wide distribution, rich diversity and great potential [0.03%]
微生物视紫红质：广泛分布、丰富多样和巨大潜力
Marie Kurihara,Yuki Sudo
Marie Kurihara
One of the major topics in biophysics and physicobiology is to understand and utilize biological functions using various advanced techniques. Taking advantage of the photoreactivity of the seven-transmembrane rhodopsin protein family has be...