Fractal dimensions for tumour-related cell types of prostate cancer on histopathology images using multiple-threshold box counting algorithm [0.03%]
基于多重阈值盒计数算法的前列腺癌组织病理图像相关肿瘤类型 fractal 维度
Anton Schwarz,Hidetaka Arimura,Yunhao Cui et al.
Anton Schwarz et al.
The malignancies of prostate tumour cells are assessed by pathologists as grade groups (GGs) from 1 (least aggressive) to 5 (most aggressive) on histopathology images. GGs are associated with the degree of tumour cell differentiation and ma...
Ritsu Mizutori,Masahiro Sugiura,Hideki Kandori
Ritsu Mizutori
Neorhodopsin (NeoR), an enzymerhodopsin, has unique molecular properties. NeoR absorbs near-infrared light whose λmax is located at 690-700 nm. Upon light absorption, NeoR is photoisomerized into the 7-cis form with low quantum yield. Uniq...
FTIR study of the wild-type and mutant proteins of a viral rhodopsin, OLPVR1 [0.03%]
OLPVR1病毒视紫红质野生型和突变体蛋白的FTIR研究
Mako Aoyama,Kota Katayama,Hideki Kandori
Mako Aoyama
OLPVR1 is a viral channelrhodopsin found in giant viruses, which can be a useful optogenetic tool for calcium-regulated cell functions. Determination of the open-state structure leads to one of the best understood channelrhodopsins. Recent ...
Selection-diversification interplay in oligonucleotide chemical evolution [0.03%]
寡核苷酸化学进化中的选择和多样化之间的相互作用
Jiro Kakizaki,Ryo Mizuuchi
Jiro Kakizaki
The emergence of catalytic RNAs (ribozymes) may have set the stage for an "RNA world" preceding protein evolution. The probability of ribozyme emergence and maintenance would have depended on available oligonucleotide compositions. Excessiv...
Ritsu Mizutori,Kota Katayama,Masae Konno et al.
Ritsu Mizutori et al.
Heliorhodopsin (HeR) is a family of microbial rhodopsin discovered in 2018, whose genes are found from archaea, bacteria, unicellular eukaryotes, and giant viruses. Viral heliorhodopsins are classified into VHeR1-4 based on their amino acid...
Physicochemical, functional, and evolutionary characteristics of protein loop regions in human and Escherichia coli proteomes [0.03%]
人类和大肠杆菌蛋白质组中蛋白环区域的理化、功能及进化特征分析
Lin Zhang,Hafumi Nishi
Lin Zhang
Protein loops play crucial roles in the formation of binding and enzyme active sites. However, general structural and biological characteristics of these loops remain unclear. In this study, we investigated loops from structural and evoluti...
Stress fiber contraction induces cell body rotation in single keratocytes [0.03%]
单个角膜细胞中张力纤维收缩诱导细胞体旋转
Chika Okimura
Chika Okimura
Single epidermal keratocytes, which are responsible for wound repair in fish, migrate while maintaining their characteristic shape: a frontal crescent-shaped lamellipodium and a posterior rugby-ball-shaped cell body. These cells are widely ...
Tony Z Jia,Yutetsu Kuruma
Tony Z Jia
Finding differentially expressed genes between cell fates predicted by image-based deep learning [0.03%]
基于图像的深度学习预测的细胞命运差异基因表达分析
Tomoaki Okaniwa,Kirill Kryukov,Katsuyuki Shiroguchi
Tomoaki Okaniwa
Finding early trigger genes involved in cell-fate-determining processes is important for understanding molecular mechanisms of, e.g., differentiation and disease progression. One of the powerful tools for the finding is hypothesis-free omic...
Visualization of peptidoglycan layer isolated from gliding diderm bacteria, Flavobacterium johnsoniae and Myxococcus xanthus, by quick-freeze deep-etch replica electron microscopy [0.03%]
采用快速冷冻深蚀刻复制电子显微镜技术观察滑行二层肽聚糖层的结构：以Flavobacterium johnsoniae和Myxococcus xanthus为例
Yuhei O Tahara,Tâm Mignot,Makoto Miyata
Yuhei O Tahara
The bacterial peptidoglycan layer plays an important role in protecting the bacteria from turgor pressure, viruses, and predators. However, it also acts as a barrier in transmitting forces generated on the cell membrane to adhesion proteins...