Application of single-molecule analysis to singularity phenomenon of cells [0.03%]
单分子分析在细胞奇异现象中的应用研究进展
Michio Hiroshima,Hiroko Bannai,Gen Matsumoto et al.
Michio Hiroshima et al.
Single-molecule imaging in living cells is an effective tool for elucidating the mechanisms of cellular phenomena at the molecular level. However, the analysis was not designed for throughput and requires high expertise, preventing it from ...
Strength in numbers: Unleashing the potential of trans-scale scope AMATERAS for massive cell quantification [0.03%]
以大规模细胞定量解析为目标发挥跨尺度联合透射电子显微镜体系的群体力量
Taro Ichimura,Taishi Kakizuka,Yuki Sato et al.
Taro Ichimura et al.
Singularity biology is a scientific field that targets drastic state changes in multicellular systems, aiming to discover the key cells that induce the state change and investigate the mechanisms behind them. To achieve this goal, we develo...
Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system [0.03%]
基于荧光定时器的T细胞动力学研究——来自Tocky系统的新见解
Masahiro Ono
Masahiro Ono
Understanding the temporal dynamics of T-cell transcription is crucial for insights into immune cell function and development. In this study, we show the features of the Timer-of-Cell-Kinetics-and-Activity (Tocky) system, which enables anal...
Elucidating molecular and cellular mechanisms of singularity phenomena in immunology [0.03%]
阐明免疫学中奇异现象的分子和细胞机制
Taku Okazaki,Tomoya Katakai
Taku Okazaki
Integration of single-cell manipulation, whole transcriptome analysis, and image-based deep learning for studying "Singularity Biology" [0.03%]
结合单细胞操作、全转录组分析和基于图像的深度学习研究“奇点生物学”
Katsuyuki Shiroguchi
Katsuyuki Shiroguchi
Takeharu Nagai
Takeharu Nagai
Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing [0.03%]
基于异质性拉曼指纹图谱评估人诱导多能干细胞的拟态生物标志物概念
Hideaki Fujita,Takayuki Haruki,Kazuhiro Sudo et al.
Hideaki Fujita et al.
Considering the fundamental mechanism causing singularity phenomena, we performed the following abduction: Assuming that a multicellular system is driven by spontaneous fluctuation of each cell and dynamic interaction of the cells, state tr...
Tomonobu M Watanabe,Tsuyoshi Shiina
Tomonobu M Watanabe
Current advances in the development of bioluminescent probes toward spatiotemporal trans-scale imaging [0.03%]
生物发光探针的最新进展促进时空跨尺度成像技术发展
Akihiro Sakama,Mariko Orioka,Yuki Hiruta
Akihiro Sakama
Bioluminescence imaging has recently attracted great attention as a highly sensitive and non-invasive analytical method. However, weak signal and low chemical stability of the luciferin are conventional drawbacks of bioluminescence imaging....
Inferring the roles of individuals in collective systems using information-theoretic measures of influence [0.03%]
基于信息论影响度量的个体在集体系统中的角色推断方法研究
Sulimon Sattari,Udoy S Basak,M Mohiuddin et al.
Sulimon Sattari et al.
In collective systems, influence of individuals can permeate an entire group through indirect interactionscom-plicating any scheme to understand individual roles from observations. A typical approach to understand an individuals influence o...