Green synthesis gold nanoparticle from Rosa damascena: antioxidant, antimicrobial, cytotoxic activities on nerve cells and inhibitory effects on Parkinson's disease [0.03%]
以玫瑰花为原料的绿色合成金纳米材料及其生物活性研究
Hamed Farjam,Shaghayegh Mohammadi,Kambiz Larijani et al.
Hamed Farjam et al.
This study investigates the green synthesis of gold nanoparticles (AuNPs) using Rosa damascena extract. . The objective is to assess the antioxidant, antimicrobial and cytotoxic activities of the biosynthesized AuNPs and to evaluate their i...
Coarse-grained molecular dynamics simulation analysis of the effects of phospholipid and cholesterol on electroporation [0.03%]
基于粗粒化的分子动力学模拟研究卵磷脂和胆固醇对电融合的影响
Qiongyao Mou,Po Hao,Tian Li et al.
Qiongyao Mou et al.
Membrane composition is a critical factor for electroporation. Although existing research focuses on pore formation driven by local phospholipid headgroup clusters, the large-scale membrane dynamics post-pore formation remain underexplored....
Multi-omics analysis of the potential association between ageing and rheumatoid arthritis and screening of potential therapeutic targets [0.03%]
多组学分析衰老与类风湿关节炎的潜在联系及潜在治疗靶点筛查
Xue Yun,Lintao Zhang,Zhaopeng Fan et al.
Xue Yun et al.
Ageing is increasingly recognized as a significant risk factor for RA, yet the molecular mechanisms linking the two remain poorly understood. This study aimed to explore the association between ageing and RA and to identify potential therap...
Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells [0.03%]
优化的聚乙二醇化紫杉醇和姜辣素共载脂质体诱导MDA-MB-231乳腺癌细胞和A549肺癌细胞G2/M期阻滞及凋亡
Priyadharshini Thangavelu,Kaavya Gunasekaran,Senthilkumar Periyathambi et al.
Priyadharshini Thangavelu et al.
The study aimed to optimize and develop novel PEGylated co-loaded nanoliposome entrapped with paclitaxel (PTX) and 6-gingerol (Gn) (PEG-Lipo-PTX-Gn) by response surface methodology (RSM) approach to prevent the diffusion and resistant-relat...
Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment [0.03%]
模拟微重力环境下破骨的机制研究：免疫-骨代谢轴在细胞外囊泡介导的干扰中的作用
Fei Yang,Changshun Chen,Chenghui Yang et al.
Fei Yang et al.
Spaceflight-related bone loss represents a critical health concern for astronauts undertaking prolonged space missions. This study investigated the mechanistic role of macrophage-derived exosomes in microgravity-induced bone loss using a si...
Injectable thermosensitive methylcellulose-carboxymethyl chitosan hydrogel for the delivery of human amniotic fluid mesenchymal stromal cell spheroids in cartilage regeneration [0.03%]
用于软骨再生的人羊水间充质干细胞球体输送的可注射温敏甲基纤维素-羧甲基壳聚糖水凝胶
Carolina Coli Zuliani,Jéssica Bruna da Cunha,Rodolpho Fagundes Correa et al.
Carolina Coli Zuliani et al.
Cartilage injuries caused by trauma or degenerative conditions such as osteoarthritis have limited intrinsic healing capacity and often require invasive interventions. This study proposes a minimally invasive therapeutic strategy using sphe...