Recent advances of CRISPR-based gene editing technologies and delivery strategies [0.03%]
基于CRISPR的基因编辑技术及递送策略的研究进展
Fanyu Xue,Zixuan Xin,Gaojie Wang et al.
Fanyu Xue et al.
CRISPR technology is a powerful tool for gene editing, in which the efficient delivery of living target cells allows it to show great clinical potential. At present, the commonly used in vivo delivery strategies mainly include biological me...
Molecular mechanisms of phytochemicals from Zanthoxylum nitidum (Roxb.) DC. against hepatocellular carcinoma: insights from network pharmacology, molecular docking, and bioinformatics [0.03%]
网络药理学、分子对接和生物信息学揭示了Zanthoxylum nitidum (Roxb.) DC.植物化学成分抗肝癌的作用机制：分子机理研究
Rongjie Zhang,Ge Zhou,Jinhai Luo et al.
Rongjie Zhang et al.
Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited therapies. We explored the anti-HCC mechanisms of Zanthoxylum nitidum (Roxb.) DC. via network pharmacology, bioinformatics and molecular docking. We identified its acti...
A scheme to tackle the dilemma from hepatoma cells under doxorubicin-resistant surroundings: a brightness or a silhouette [0.03%]
应对多柔比星抗性环境下肝癌细胞困境的策略：一线曙光还是徒增困扰？
Ki-Kwang Oh,Goo-Hyun Kwon,Jung-A Eom et al.
Ki-Kwang Oh et al.
Background: The aim of this study was to investigate key target(s), mechanism(s) from hepatoma cells in harsh doxorubicin-resistant conditions (DRCs) from GSE125180 datasets in GEO (Gene Expression Omnibus). ...
Multiomics integrative bioinformatics analysis of gene expression characteristics and molecular mechanisms in preeclampsia placental tissue [0.03%]
子痫前期胎盘组织基因表达特征及分子机制的多组学整合生物信息学分析
Ni Li,Lin Tian,Haiyun Wei
Ni Li
Preeclampsia (PE) is a severe pregnancy-specific complication characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, which can cause multi-organ damage and life-threatening outcomes for both mothers and foetuse...