Fibroblasts/three-dimensional scaffolds complexes promote wound healing in rats with skin defects [0.03%]
成纤维细胞/三维支架复合物促进皮肤缺损大鼠创面修复
Ting Jiang,Qiang Liu,Er-Chang Xu et al.
Ting Jiang et al.
We aim to construct a three-dimensional nano-skin scaffold material in vitro and study its promoting effect on wound healing in vivo. In this study, hybrid constructs of three-dimensional (3D) scaffolds were successfully fabricated by combi...
Inter-claudin antagonism of paracellular pore function: mechanism and beyond [0.03%]
连接蛋白在旁路通道功能中的相互拮抗作用：机制及展望
Wanapas Wachiradejkul,Pawin Pongkorpsakol
Wanapas Wachiradejkul
Claudin-2-dependent pore function mediates paracellular cation permeability and can result in pathogenesis of many diseases. Although existing various types of claudins, including barrier-forming and pore-forming claudins, their heterodimer...
1,25(OH)2D3 supplementation alleviates gut-vascular barrier disruption via inhibition of S100B/ADAM10 pathway [0.03%]
1,25（OH）2D3补充剂通过抑制S100B/ADAM10通路缓解肠道血管屏障破坏
Aiwen Feng,Cheng Li,Shaosheng Su et al.
Aiwen Feng et al.
Gut-vascular barrier (GVB) is the second barrier in mucosa to control systemic dissemination of gut bacteria. Severe burns induce enteroglial cells to produce S100B and endothelial cells to generate ADAM10 and cause vitamin D3 insufficiency...
Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling [0.03%]
具有TEER的高度可扩展和标准化的器官芯片平台用于生物屏障建模
Hoang-Tuan Nguyen,Siiri-Liisa Rissanen,Mimosa Peltokangas et al.
Hoang-Tuan Nguyen et al.
The development of new therapies is hampered by the lack of predictive, and patient-relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate physiological features and hold great promise for tissue and disease mod...
Dorrian G Cohen,Rebecca A Wingert
Dorrian G Cohen
Inflammatory bowel diseases (IBDs) are chronic conditions in which the digestive tract undergoes cycles of relapsing and remitting inflammatory episodes that cause patients to experience severe abdominal pain, bleeding, and diarrhea. Develo...
Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of Cryptococcus neoformans during mammalian passage [0.03%]
红色羽毛被捕捉：丛枝菌属在哺乳动物体内从长尾鹦鹉到人和小鼠的感染揭示了其基因可塑性
Dorrian G Cohen,Rebecca A Wingert
Dorrian G Cohen
The fungus Cryptococcus neoformans is pervasive in our environment and causes the infectious disease cryptococcosis in humans, most commonly in immunocompromised patients. In addition to corroborating the avian origins of a case of cryptoco...
Tails of nephron ciliated cell development: insights on patterning a functional tissue barrier from the zebrafish [0.03%]
肾小管纤毛细胞发育的历程：来自斑马鱼的功能性组织屏障模式化的启示
Sophia Baker,Thanh Khoa Nguyen,Rebecca A Wingert
Sophia Baker
Cilia are hair-like structures found on the surface of nearly all vertebrate cell types where they have central roles in regulating development and orchestrating physiological events. There is growing interest in understanding the mechanism...
Slow down my beating heart: induction of cardiac fibrosis by Iroquois homeobox 2 [0.03%]
减慢我悸动的心：Iroquois homeo box 2诱导心脏纤维化
Madeline Petrikas,Rebecca A Wingert
Madeline Petrikas
Cardiovascular diseases are a significant global health challenge and pervasive cause of mortality worldwide. Heart failure due to cardiovascular disease is characterized by the inability of the heart to pump blood efficiently to meet the m...
Kursad Turksen
Kursad Turksen
The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line [0.03%]
上皮渗透性屏障，细胞迁移和人子宫内膜癌细胞系中生长因子及其抑制剂的线粒体代谢之间的相互作用
Takumi Konno,Takayuki Kohno,Shin Kikuchi et al.
Takumi Konno et al.
It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhib...