Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling [0.03%]
具有TEER的高度可扩展和标准化的器官芯片平台用于生物屏障建模
Hoang-Tuan Nguyen,Siiri-Liisa Rissanen,Mimosa Peltokangas et al.
Hoang-Tuan Nguyen et al.
The development of new therapies is hampered by the lack of predictive, and patient-relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate physiological features and hold great promise for tissue and disease mod...
Dorrian G Cohen,Rebecca A Wingert
Dorrian G Cohen
Inflammatory bowel diseases (IBDs) are chronic conditions in which the digestive tract undergoes cycles of relapsing and remitting inflammatory episodes that cause patients to experience severe abdominal pain, bleeding, and diarrhea. Develo...
Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of Cryptococcus neoformans during mammalian passage [0.03%]
红色羽毛被捕捉：丛枝菌属在哺乳动物体内从长尾鹦鹉到人和小鼠的感染揭示了其基因可塑性
Dorrian G Cohen,Rebecca A Wingert
Dorrian G Cohen
The fungus Cryptococcus neoformans is pervasive in our environment and causes the infectious disease cryptococcosis in humans, most commonly in immunocompromised patients. In addition to corroborating the avian origins of a case of cryptoco...
Tails of nephron ciliated cell development: insights on patterning a functional tissue barrier from the zebrafish [0.03%]
肾小管纤毛细胞发育的历程：来自斑马鱼的功能性组织屏障模式化的启示
Sophia Baker,Thanh Khoa Nguyen,Rebecca A Wingert
Sophia Baker
Cilia are hair-like structures found on the surface of nearly all vertebrate cell types where they have central roles in regulating development and orchestrating physiological events. There is growing interest in understanding the mechanism...
Slow down my beating heart: induction of cardiac fibrosis by Iroquois homeobox 2 [0.03%]
减慢我悸动的心：Iroquois homeo box 2诱导心脏纤维化
Madeline Petrikas,Rebecca A Wingert
Madeline Petrikas
Cardiovascular diseases are a significant global health challenge and pervasive cause of mortality worldwide. Heart failure due to cardiovascular disease is characterized by the inability of the heart to pump blood efficiently to meet the m...
Kursad Turksen
Kursad Turksen
The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line [0.03%]
上皮渗透性屏障，细胞迁移和人子宫内膜癌细胞系中生长因子及其抑制剂的线粒体代谢之间的相互作用
Takumi Konno,Takayuki Kohno,Shin Kikuchi et al.
Takumi Konno et al.
It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhib...
Membrane lipid composition of bronchial epithelial cells influences antiviral responses during rhinovirus infection [0.03%]
支气管上皮细胞的膜脂组成影响鼻病毒感染期间的抗病毒反应
Madhuriben H Panchal,Emily J Swindle,Theresa J Pell et al.
Madhuriben H Panchal et al.
Lipids and their mediators have important regulatory functions in many cellular processes, including the innate antiviral response. The aim of this study was to compare the lipid membrane composition of in vitro differentiated primary bronc...
8-Bromo-cAMP attenuates human airway epithelial barrier disruption caused by titanium dioxide fine and nanoparticles [0.03%]
8-溴-cAMP减轻由二氧化钛细颗粒和纳米颗粒造成的对人呼吸道上皮屏障的破坏
Claire E Lee,Andjela Raduka,Nannan Gao et al.
Claire E Lee et al.
Titanium dioxide fine particles (TiO2-FPs) and nanoparticles (TiO2-NPs) are the most widely used whitening pigments worldwide. Inhalation of TiO2-FPs and TiO2-NPs can be harmful as it triggers toxicity in the airway epithelial cells. The ai...
Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases [0.03%]
阿尔茨海默病和帕金森病新疗法研究中奥格利lutide、杜拉lutide、替扎patide和DA5-CH的脑摄取药代动力学
Elizabeth M Rhea,Alice Babin,Peter Thomas et al.
Elizabeth M Rhea et al.
Background: A number of peptide incretin receptor agonists (IRAs) show promise as therapeutics for Alzheimer's disease (AD) and Parkinson's disease (PD). Transport across the blood-brain barrier (BBB) is one way for IRAs ...