Deependra Singh,Saurabh Kumar,Rajnikant Mishra et al.
Deependra Singh et al.
The blood-testis barrier is a specialized feature within the mammalian testis, located in close proximity to the basement membrane of seminiferous tubules. This barrier serves to divide the seminiferous epithelium into distinct basal and ad...
Effects of small extracellular vesicles derived from normoxia- and hypoxia-treated prostate cancer cells on the submandibular salivary gland epithelium in vitro [0.03%]
体外正常氧和低氧处理的前列腺癌细胞源的小细胞外囊泡对颌下腺上皮的影响
Ana Špilak,Andreas Brachner,Heinz-Peter Friedl et al.
Ana Špilak et al.
Small extracellular vesicles (sEVs) are an important part of intercellular communication. They are phospholipid bilayer particles that carry active biomolecules such as proteins, various nucleic acids, and lipids. In recipient cells, sEVs c...
Molecular alterations in claudin 18 suppressed and non-suppressed gastric adenocarcinomas to guide targeted therapies [0.03%]
用于指导靶向治疗的Claudin 18阴性和阳性胃腺癌的分子改变
Ioannis A Voutsadakis
Ioannis A Voutsadakis
Background: Gastric adenocarcinoma represents an aggressive type of cancer and an important cause of cancer mortality. Progress in gastric cancer therapeutics has resulted from a better understanding of the molecular path...
Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function [0.03%]
高血糖通过其对内皮细胞特性和功能的影响破坏血脑屏障的完整性
Arshad Hashmat,Jingyuan Ya,Rais Kadir et al.
Arshad Hashmat et al.
Breakdown of blood-brain barrier (BBB) represents a key pathology in hyperglycemia-mediated cerebrovascular damage after an ischemic stroke. As changes in the level and nature of vasoactive agents released by endothelial cells (ECs) may con...
The correlation between fecal microbiota profiles and intracellular junction genes expression in young Iranian patients with celiac disease [0.03%]
伊朗年轻乳糜泻患者肠道菌群与细胞内桥基因表达的相关性研究
Mohadeseh Mahmoudi Ghehsareh,Nastaran Asri,Fahimeh Sadat Gholam-Mostafaei et al.
Mohadeseh Mahmoudi Ghehsareh et al.
Celiac disease (CD) is characterized by the disruption of the intestinal barrier integrity and alterations in the microbiota composition. This study aimed to evaluate the changes in the fecal microbiota profile and mRNA expressions of intra...
Spermine oxidase inhibitor, MDL 72527, reduced neovascularization, vascular permeability, and acrolein-conjugated proteins in a mouse model of ischemic retinopathy [0.03%]
Spermine氧化酶抑制剂MDL 72527降低缺血性视网膜病变小鼠模型中的新生血管、血管通透性和丙烯醛连接蛋白
Abdullah Alhumaid,Fang Liu,Shengshuai Shan et al.
Abdullah Alhumaid et al.
Disruptions in polyamine metabolism have been identified as contributing factors to various central nervous system disorders. Our laboratory has previously highlighted the crucial role of polyamine oxidation in retinal disease models, speci...
The connection between fatty acids and inflammation in celiac disease; a deep exploring [0.03%]
脂肪酸和乳糜泻炎症之间的关系；深入探究
Sajjad Bakhtiari,Nastaran Asri,Mahtab Jahdkaran et al.
Sajjad Bakhtiari et al.
The interplay between fatty acids (FAs) and celiac disease (CD) is a burgeoning field of research with significant implications for understanding the pathophysiology and potential therapeutic avenues for this autoimmune disorder. CD, trigge...
Fibroblasts/three-dimensional scaffolds complexes promote wound healing in rats with skin defects [0.03%]
成纤维细胞/三维支架复合物促进皮肤缺损大鼠创面修复
Ting Jiang,Qiang Liu,Er-Chang Xu et al.
Ting Jiang et al.
We aim to construct a three-dimensional nano-skin scaffold material in vitro and study its promoting effect on wound healing in vivo. In this study, hybrid constructs of three-dimensional (3D) scaffolds were successfully fabricated by combi...
Inter-claudin antagonism of paracellular pore function: mechanism and beyond [0.03%]
连接蛋白在旁路通道功能中的相互拮抗作用：机制及展望
Wanapas Wachiradejkul,Pawin Pongkorpsakol
Wanapas Wachiradejkul
Claudin-2-dependent pore function mediates paracellular cation permeability and can result in pathogenesis of many diseases. Although existing various types of claudins, including barrier-forming and pore-forming claudins, their heterodimer...
1,25(OH)2D3 supplementation alleviates gut-vascular barrier disruption via inhibition of S100B/ADAM10 pathway [0.03%]
1,25（OH）2D3补充剂通过抑制S100B/ADAM10通路缓解肠道血管屏障破坏
Aiwen Feng,Cheng Li,Shaosheng Su et al.
Aiwen Feng et al.
Gut-vascular barrier (GVB) is the second barrier in mucosa to control systemic dissemination of gut bacteria. Severe burns induce enteroglial cells to produce S100B and endothelial cells to generate ADAM10 and cause vitamin D3 insufficiency...