Erk1/2 is not required for endothelial barrier establishment despite its requirement for cAMP-dependent Rac1 activation in heart endothelium [0.03%]
ERK1/2不参与内皮屏障的建立，但其对于cAMP依赖性的Rac1活化在心脏内皮中是必需的
Sina Moztarzadeh,Hilda Vargas-Robles,Michael Schnoor et al.
Sina Moztarzadeh et al.
The contribution of Erk1/2 to endothelial barrier regulation is convoluted and differs depending on the vascular bed. We explored the effects of Erk1/2 inhibition on endothelial barrier maintenance and its relationship with cAMP-dependent b...
Oncostatin M promotes epithelial barrier dysfunction in patients with eosinophilic chronic rhinosinusitis with nasal polyps [0.03%]
肿瘤坏死因子M促进嗜酸细胞性慢性鼻窦炎伴鼻息肉上皮屏障功能障碍
Bao-Feng Wang,Ying-Ying Wang,Hai Lin et al.
Bao-Feng Wang et al.
Background: Oncostatin M (OSM) may be involved in the promotion of mucosal epithelial barrier dysfunction in patients with eosinophilic chronic rhinosinusitis with nasal polyps (Eos CRSwNP) by inducing matrix metalloprote...
Epithelial barrier dysfunction and microbial dysbiosis: exploring the pathogenesis and therapeutic strategies for Crohn's disease [0.03%]
肠上皮屏障功能障碍与微生物菌群失调：探索克罗恩病的发病机制和治疗策略
Tunç Akkoç
Tunç Akkoç
Crohn's disease (CD), a chronic gastrointestinal inflammatory disease, is becoming more widespread worldwide. Crohn's disease is caused by gut microbiota changes, genetics, environmental stresses, and immunological responses. Current treatm...
Nesa Kazemifard,Nafiseh Golestani,Kasra Jahankhani et al.
Nesa Kazemifard et al.
Ulcerative colitis (UC) is a chronic and debilitating disorder that falls under the broad category of inflammatory bowel disease (IBD). Therefore, affects the colon and rectum, resulting in inflammation and ulcers in the lining of these org...
Claudin-12: guardian of the tissue barrier or friend of tumor cells [0.03%]
Claudin-12：组织屏障的守护者还是肿瘤细胞的朋友？
Desislava Apostolova,Georgi Apostolov,Dzhemal Moten et al.
Desislava Apostolova et al.
Tight junctions (TJs) are an important component of cellular connectivity. Claudin family proteins, as a constituent of TJs, determine their barrier properties, cell polarity and paracellular permeability. Claudin-12 is an atypical member o...
The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs? [0.03%]
糖尿病对血组织屏障调节和血管并发症的影响：肺与其他器官不同吗？
Abdulaziz H Alanazi,Mohamed S Selim,Manyasreeprapti R Yendamuri et al.
Abdulaziz H Alanazi et al.
Diabetes Mellitus presents a formidable challenge as one of the most prevalent and complex chronic diseases, exerting significant strain on both patients and the world economy. It is recognized as a common comorbidity among severely ill ind...
Mahtab Jahdkaran,Nastaran Asri,Hadi Esmaily et al.
Mahtab Jahdkaran et al.
Celiac Disease (CD) is the most common hereditarily-based food intolerance worldwide and a chronic inflammatory condition. The current standard treatment for CD involves strict observance and compliance with a gluten-free diet (GFD). Howeve...
The roles of tight junction protein cingulin in human endometrioid endometrial cancer [0.03%]
黏带蛋白在人子宫内膜样癌中的作用研究
Arisa Kura,Kimihito Saito,Takumi Konno et al.
Arisa Kura et al.
The bicellular tight junction molecule cingulin (CGN) binds to microtubules in centrosomes. Furthermore, CGN contributes to the tricellular tight junction (tTJ) proteins lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin (TRIC)...
The stratum corneum barrier: impaired function in relation to associated lipids and proteins [0.03%]
角质层屏障：与相关脂质和蛋白质有关的功能障碍
Jie Chen,Changjie Liu,Yuan Yang et al.
Jie Chen et al.
The skin is the largest organ of the human body and is widely considered to be the first-line defense of the body, providing essential protection against mechanical, physical, and chemical damage. Keratinocytes are the primary cells of the ...
The role of reactive oxygen species in the regulation of the blood-brain barrier [0.03%]
反应性氧种类在血脑屏障调节中的作用
Margarita Shuvalova,Anastasiia Dmitrieva,Vsevolod Belousov et al.
Margarita Shuvalova et al.
The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (RO...