The application of explants, crypts, and organoids as models in intestinal barrier research [0.03%]
肠屏障研究中应用类器官、类芽肿和类器官作为模型的研究
Snezhanna Medvedeva,Kseniya Achasova,Lidiya Boldyreva et al.
Snezhanna Medvedeva et al.
In vitro models are of great importance in advancing our understanding of human diseases, especially complex disorders with unknown etiologies like inflammatory bowel diseases (IBD). One of the key IBD features is the increased intestinal p...
The protective effects of apelin-13 in HIV-1 tat- induced macrophage infiltration and BBB impairment [0.03%]
Apelin-13对HIV-1蛋白 Tat诱导的巨噬细胞浸润及血脑屏障损害的保护作用研究
Qi Cao,Wei Zeng,Jingmin Nie et al.
Qi Cao et al.
Impairment of the blood - brain barrier (BBB) and subsequent inflammatory responses contribute to the development of human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND). Apelin-13, the most abundant member of the...
Multiciliated cell development and ciliary resorption at the mammalian choroid plexus [0.03%]
哺乳动物脉络丛的多纤毛细胞发育及其纤毛吸收现象
Ashini Kaushik,Rebecca A Wingert
Ashini Kaushik
Ciliopathies are a group of diseases caused by defects in cilia, hair-like organelles that can have many functions ranging from regulating extracellular fluid flow to sensing mechanical or chemical stimuli. Multiciliated cells (MCCs) with m...
Erk1/2 is not required for endothelial barrier establishment despite its requirement for cAMP-dependent Rac1 activation in heart endothelium [0.03%]
ERK1/2不参与内皮屏障的建立，但其对于cAMP依赖性的Rac1活化在心脏内皮中是必需的
Sina Moztarzadeh,Hilda Vargas-Robles,Michael Schnoor et al.
Sina Moztarzadeh et al.
The contribution of Erk1/2 to endothelial barrier regulation is convoluted and differs depending on the vascular bed. We explored the effects of Erk1/2 inhibition on endothelial barrier maintenance and its relationship with cAMP-dependent b...
Oncostatin M promotes epithelial barrier dysfunction in patients with eosinophilic chronic rhinosinusitis with nasal polyps [0.03%]
肿瘤坏死因子M促进嗜酸细胞性慢性鼻窦炎伴鼻息肉上皮屏障功能障碍
Bao-Feng Wang,Ying-Ying Wang,Hai Lin et al.
Bao-Feng Wang et al.
Background: Oncostatin M (OSM) may be involved in the promotion of mucosal epithelial barrier dysfunction in patients with eosinophilic chronic rhinosinusitis with nasal polyps (Eos CRSwNP) by inducing matrix metalloprote...
Epithelial barrier dysfunction and microbial dysbiosis: exploring the pathogenesis and therapeutic strategies for Crohn's disease [0.03%]
肠上皮屏障功能障碍与微生物菌群失调：探索克罗恩病的发病机制和治疗策略
Tunç Akkoç
Tunç Akkoç
Crohn's disease (CD), a chronic gastrointestinal inflammatory disease, is becoming more widespread worldwide. Crohn's disease is caused by gut microbiota changes, genetics, environmental stresses, and immunological responses. Current treatm...
Nesa Kazemifard,Nafiseh Golestani,Kasra Jahankhani et al.
Nesa Kazemifard et al.
Ulcerative colitis (UC) is a chronic and debilitating disorder that falls under the broad category of inflammatory bowel disease (IBD). Therefore, affects the colon and rectum, resulting in inflammation and ulcers in the lining of these org...
Claudin-12: guardian of the tissue barrier or friend of tumor cells [0.03%]
Claudin-12：组织屏障的守护者还是肿瘤细胞的朋友？
Desislava Apostolova,Georgi Apostolov,Dzhemal Moten et al.
Desislava Apostolova et al.
Tight junctions (TJs) are an important component of cellular connectivity. Claudin family proteins, as a constituent of TJs, determine their barrier properties, cell polarity and paracellular permeability. Claudin-12 is an atypical member o...
The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs? [0.03%]
糖尿病对血组织屏障调节和血管并发症的影响：肺与其他器官不同吗？
Abdulaziz H Alanazi,Mohamed S Selim,Manyasreeprapti R Yendamuri et al.
Abdulaziz H Alanazi et al.
Diabetes Mellitus presents a formidable challenge as one of the most prevalent and complex chronic diseases, exerting significant strain on both patients and the world economy. It is recognized as a common comorbidity among severely ill ind...
Mahtab Jahdkaran,Nastaran Asri,Hadi Esmaily et al.
Mahtab Jahdkaran et al.
Celiac Disease (CD) is the most common hereditarily-based food intolerance worldwide and a chronic inflammatory condition. The current standard treatment for CD involves strict observance and compliance with a gluten-free diet (GFD). Howeve...