Lipopolysaccharide transport during long-chain fatty acid exposure is mediated by caveolin-1 dependent endocytosis in murine jejunum [0.03%]
长链脂肪酸暴露期间鼠空肠中脂多糖转运由caveolin-1依赖性胞吞作用介导
Yasutada Akiba,Shin Nishii,Akinori Mizoguchi et al.
Yasutada Akiba et al.
The entry of bacterial-derived lipopolysaccharides (LPS) from the intestinal lumen to the circulation induces low-grade systemic inflammation. We have found that LPS is transcellularly transported to the portal vein during luminal long-chai...
VE-cadherin RGD motifs are dispensable for cell-cell junctions, endothelial barrier function and monocyte extravasation [0.03%]
VE-钙粘蛋白RGD基序对于细胞间连接、内皮屏障功能和单核细胞外渗是不必要的
Rianne M Schoon,Werner J van der Meer,Anne-Marieke D van Stalborch et al.
Rianne M Schoon et al.
VE-cadherin is a key transmembrane protein involved in endothelial cell-cell junctions, playing a crucial role in maintaining vascular integrity and regulating selective leukocyte extravasation into inflamed tissue. The extracellular domain...
Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional proteins in traumatic brain injury [0.03%]
Claudin-1通过下调血管内皮连接蛋白在创伤性脑损伤中影响血脑屏障功能
Saiprasad Gowrikumar,Aria Tarudji,Brandon Z McDonald et al.
Saiprasad Gowrikumar et al.
Traumatic brain injury (TBI) is a leading cause of death and disability in patients. Brain microvasculature endothelial cells form the blood-brain barrier (BBB) which functions to maintain a protective barrier for the brain from the passive...
A novel approach for lymphatic organoid embedding: eosin pre-staining and agarose pre-embedding [0.03%]
淋巴类器官包埋的一种新方法：伊红预染色和琼脂糖预包埋
Bao-Feng Wang,Ying-Ying Wang,Yun-Lan Yi et al.
Bao-Feng Wang et al.
Adenoid organoids, as the primary immune barrier of the airway, provide valuable models for studying lymphatic tissue function, but their histological processing remains challenging due to their fragile structure and lack of adhesion. Here,...
Modulating nasal barrier function and tissue remodeling in inflammatory diseases: the role of ginseng and its bioactive compounds [0.03%]
鼻炎性疾病中的人参及其生物活性成分对屏障功能及组织重塑的调节作用
Giovanna Lucia Piazzetta,Nadia Lobello,Corrado Pelaia et al.
Giovanna Lucia Piazzetta et al.
Ginseng, a well-known herbal supplement, is widely recognized for its pharmacological properties, including anti-inflammatory, antioxidant, and immune-modulatory effects. This review explores the potential therapeutic benefits of ginseng, p...
Frataxin deficiency and the pathology of Friedreich's Ataxia across tissues [0.03%]
_frataxin_的缺乏与弗瑞德里希共济失调症在各组织中的病理表现
Wesley S Ercanbrack,Mateo Ramirez,Austin Dungan et al.
Wesley S Ercanbrack et al.
Friedreich's Ataxia (FRDA) is a neurodegenerative disease that affects a variety of different organ systems. The disease is caused by GAA repeat expansions in intron 1 of the Frataxin gene (FXN), which results in a decrease in the expressio...
β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility [0.03%]
β- Arrestin 1 和整联蛋白连接激酶在表皮角化细胞中相互作用并调节细胞运动性
Hannah Murphy-Marshman,Iordanka A Ivanova,Moshmi Bhattacharya et al.
Hannah Murphy-Marshman et al.
Arrestins and integrin-linked kinase (ILK) are important scaffold proteins that regulate myriad cell functions in metazoans. β-arrestins, first identified as critical components in G-protein-coupled receptor (GPCR) signaling pathways, part...
Ephrin-Eph signaling: an important regulator of epithelial integrity and barrier function [0.03%]
Ephrin-Eph信号传导：上皮完整性及屏障功能的重要调节因子
Mohan Liu,Joseph G Charek,Rodolfo D Vicetti Miguel et al.
Mohan Liu et al.
Eph receptor-interacting proteins (ephrin) ligands and their erythropoietin-producing human hepatocellular (Eph) receptors elicit bidirectional signals that regulate cell migration, angiogenesis, neuronal plasticity, and other developmental...
Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin [0.03%]
列表菌素和清单素 iota 毒素受体结合区对紧密连接的尺寸选择性渗透增强调节作用
Keisuke Tachibana,Sayaka Sugimura,Shuko Sakimura et al.
Keisuke Tachibana et al.
Modulation of claudin-based bicellular tight junction (TJ) and angulin-based tricellular TJ seals has been shown to enhance mucosal permeation of macromolecules, by using the receptor-binding fragments of Clostridium perfringens enterotoxin...
Fistula in Crohn's disease: classification, pathogenesis, and treatment options [0.03%]
克罗恩病肛瘘的分类、发病机制和治疗选择
Kimia Basiji,Nesa Kazemifard,Maryam Farmani et al.
Kimia Basiji et al.
Crohn's disease is a form of inflammation that affects the gastrointestinal (GI) tract. It is characterized by persistent inflammation in the gut, which can lead to the formation of abnormal connections called fistulas. These fistulas can o...