Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions [0.03%]
处于血脑屏障完整性和神经退行性病变交叉路口的去泛素酶：机制见解，治疗靶向和未来方向
Fahima Munavar-K,Nibedita Lenka
Fahima Munavar-K
The ubiquitin-proteasome system (UPS) carries immense significance concerning cellular homeostasis that encompasses both ubiquitination and deubiquitination as key facets for maintaining protein stability. The deubiquitinating enzymes (DUBs...
Tissue microRNA dynamics in sinonasal inverted papilloma: implications for pathology and therapy [0.03%]
鼻窦 inverted papilloma的组织微小RNA动态变化及其病理和治疗意义
Giovanna Lucia Piazzetta,Nadia Lobello,Corrado Pelaia et al.
Giovanna Lucia Piazzetta et al.
Sinonasal inverted papilloma (SNIP) is a benign epithelial neoplasm of the Schneiderian membrane, known for its locally aggressive behavior, high recurrence rates, and potential for malignant transformation into sinonasal squamous cell carc...
The effects of decellularized amniotic membrane and Wharton's jelly on the healing of experimental skin wounds in rats [0.03%]
脱细胞胎盘膜和滑膜液对大鼠实验性皮肤伤口愈合的影响
Aline L Takejima,Rossana B Simeoni,Milka L Takejima et al.
Aline L Takejima et al.
Several studies have focused on novel therapeutic strategies for extensive skin lesions aiming to improve healing quality and reduce treatment duration. In this context, the use of amniotic membrane (AM) and Wharton's jelly (WJ) emerges as ...
Therapeutic effects of selenium nanoparticles versus selenium on experimentally induced diabetic retinopathy via modulation of TLR4 / NF-kB P65 / VEGF / connexin 43 signaling [0.03%]
硒纳米颗粒与硒通过调节TLR4/NF-KB P65/VEGF/连接蛋白43信号对实验性糖尿病视网膜病变的治疗作用
Nafesa Ashraf Mahmoud Khashaba,Sara Mohamed Naguib Abdel Hafez,Walaa Yehia Abdelzaher et al.
Nafesa Ashraf Mahmoud Khashaba et al.
Diabetic retinopathy is the most prevalent microvascular consequences of diabetes mellitus that can result in vision loss. Nanotechnology has been widely used in the treatment of ophthalmic diseases. Selenium is a naturally occurring compou...
Lanreotide protects against LPS-induced inflammation in endothelial cells and mouse lungs [0.03%]
兰瑞肽保护内皮细胞和小鼠肺免受脂多糖诱导的炎症损害
Md Matiur Rahman Sarker,Saikat Fakir,Khadeja-Tul Kubra et al.
Md Matiur Rahman Sarker et al.
Somatostatin is expressed in various tissues - including the hypothalamus - and strongly suppresses Growth Hormone levels to maintain homeostasis. Synthetic somatostatin analogs are currently used in clinics to treat neuroendocrine tumors a...
E2, Brute? Unveiling an unexpected role of estrogen signaling in nephrogenesis during embryonic zebrafish kidney development [0.03%]
E2、野蛮？在斑马鱼胚胎肾脏发育过程中揭开雌激素信号的意想不到的作用
Landon B Gibbins,Dorrian G Cohen,Rebecca A Wingert
Landon B Gibbins
Recent years have heralded many exciting advancements in our knowledge about kidney development. In particular, there has been tremendous progress in identifying genes and signaling pathways that pattern renal functional units - a process k...
Lipopolysaccharide transport during long-chain fatty acid exposure is mediated by caveolin-1 dependent endocytosis in murine jejunum [0.03%]
长链脂肪酸暴露期间鼠空肠中脂多糖转运由caveolin-1依赖性胞吞作用介导
Yasutada Akiba,Shin Nishii,Akinori Mizoguchi et al.
Yasutada Akiba et al.
The entry of bacterial-derived lipopolysaccharides (LPS) from the intestinal lumen to the circulation induces low-grade systemic inflammation. We have found that LPS is transcellularly transported to the portal vein during luminal long-chai...
VE-cadherin RGD motifs are dispensable for cell-cell junctions, endothelial barrier function and monocyte extravasation [0.03%]
VE-钙粘蛋白RGD基序对于细胞间连接、内皮屏障功能和单核细胞外渗是不必要的
Rianne M Schoon,Werner J van der Meer,Anne-Marieke D van Stalborch et al.
Rianne M Schoon et al.
VE-cadherin is a key transmembrane protein involved in endothelial cell-cell junctions, playing a crucial role in maintaining vascular integrity and regulating selective leukocyte extravasation into inflamed tissue. The extracellular domain...
Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional proteins in traumatic brain injury [0.03%]
Claudin-1通过下调血管内皮连接蛋白在创伤性脑损伤中影响血脑屏障功能
Saiprasad Gowrikumar,Aria Tarudji,Brandon Z McDonald et al.
Saiprasad Gowrikumar et al.
Traumatic brain injury (TBI) is a leading cause of death and disability in patients. Brain microvasculature endothelial cells form the blood-brain barrier (BBB) which functions to maintain a protective barrier for the brain from the passive...