Advanced glycation endproducts induce cytokine dysregulation and weaken lung epithelial and endothelial barrier integrity [0.03%]
advanced glycation末端产物诱导细胞因子失调并削弱肺上皮和内皮屏障完整性
Abdulaziz H Alanazi,Mohamed S Selim,Yin Zhu et al.
Abdulaziz H Alanazi et al.
Diabetes mellitus is a systemic disease characterized by chronic hyperglycemia, persistent inflammation, and oxidative stress. While the vascular complications of diabetes are well-documented, their impact on lung barrier integrity remains ...
Chenchen An,Chonggui Jiang,Wangxiang Pei et al.
Chenchen An et al.
This comprehensive review delves into the pivotal role of intestinal epithelial cells in the context of various diseases. It provides an in-depth analysis of the diverse types and functions of these cells, explores the influence of multiple...
Paracrine signaling mediators of vascular endothelial barrier dysfunction in sepsis: implications for therapeutic targeting [0.03%]
脓毒症血管内皮屏障功能障碍的旁分泌信号介质：治疗靶向的启示
Shahid Puthiyottil,Tom Skaria
Shahid Puthiyottil
Vascular endothelial barrier disruption is a critical determinant of morbidity and mortality in sepsis. Whole blood represents a key source of paracrine signaling molecules inducing vascular endothelial barrier disruption in sepsis. This st...
Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions [0.03%]
处于血脑屏障完整性和神经退行性病变交叉路口的去泛素酶：机制见解，治疗靶向和未来方向
Fahima Munavar-K,Nibedita Lenka
Fahima Munavar-K
The ubiquitin-proteasome system (UPS) carries immense significance concerning cellular homeostasis that encompasses both ubiquitination and deubiquitination as key facets for maintaining protein stability. The deubiquitinating enzymes (DUBs...
Tissue microRNA dynamics in sinonasal inverted papilloma: implications for pathology and therapy [0.03%]
鼻窦 inverted papilloma的组织微小RNA动态变化及其病理和治疗意义
Giovanna Lucia Piazzetta,Nadia Lobello,Corrado Pelaia et al.
Giovanna Lucia Piazzetta et al.
Sinonasal inverted papilloma (SNIP) is a benign epithelial neoplasm of the Schneiderian membrane, known for its locally aggressive behavior, high recurrence rates, and potential for malignant transformation into sinonasal squamous cell carc...
The effects of decellularized amniotic membrane and Wharton's jelly on the healing of experimental skin wounds in rats [0.03%]
脱细胞胎盘膜和滑膜液对大鼠实验性皮肤伤口愈合的影响
Aline L Takejima,Rossana B Simeoni,Milka L Takejima et al.
Aline L Takejima et al.
Several studies have focused on novel therapeutic strategies for extensive skin lesions aiming to improve healing quality and reduce treatment duration. In this context, the use of amniotic membrane (AM) and Wharton's jelly (WJ) emerges as ...
Therapeutic effects of selenium nanoparticles versus selenium on experimentally induced diabetic retinopathy via modulation of TLR4 / NF-kB P65 / VEGF / connexin 43 signaling [0.03%]
硒纳米颗粒与硒通过调节TLR4/NF-KB P65/VEGF/连接蛋白43信号对实验性糖尿病视网膜病变的治疗作用
Nafesa Ashraf Mahmoud Khashaba,Sara Mohamed Naguib Abdel Hafez,Walaa Yehia Abdelzaher et al.
Nafesa Ashraf Mahmoud Khashaba et al.
Diabetic retinopathy is the most prevalent microvascular consequences of diabetes mellitus that can result in vision loss. Nanotechnology has been widely used in the treatment of ophthalmic diseases. Selenium is a naturally occurring compou...
Lanreotide protects against LPS-induced inflammation in endothelial cells and mouse lungs [0.03%]
兰瑞肽保护内皮细胞和小鼠肺免受脂多糖诱导的炎症损害
Md Matiur Rahman Sarker,Saikat Fakir,Khadeja-Tul Kubra et al.
Md Matiur Rahman Sarker et al.
Somatostatin is expressed in various tissues - including the hypothalamus - and strongly suppresses Growth Hormone levels to maintain homeostasis. Synthetic somatostatin analogs are currently used in clinics to treat neuroendocrine tumors a...
E2, Brute? Unveiling an unexpected role of estrogen signaling in nephrogenesis during embryonic zebrafish kidney development [0.03%]
E2、野蛮？在斑马鱼胚胎肾脏发育过程中揭开雌激素信号的意想不到的作用
Landon B Gibbins,Dorrian G Cohen,Rebecca A Wingert
Landon B Gibbins
Recent years have heralded many exciting advancements in our knowledge about kidney development. In particular, there has been tremendous progress in identifying genes and signaling pathways that pattern renal functional units - a process k...