Apoorva,Sunit K Singh
Apoorva
Blood-tissue barriers (BTBs) are highly specialized, selectively permeable surfaces that separate the circulatory system from delicate tissues and organs. Critical examples include the blood-brain barrier (BBB), blood-retinal barrier (BRB),...
Patient-derived 3D nasal spheroids reveal epithelial changes following Dupilumab therapy in CRSwNP: a preliminary report [0.03%]
基于患者的3D鼻球体模型揭示了Dupilumab治疗CRSwNP后的上皮变化：初步报告
Nadia Lobello,Giovanna Lucia Piazzetta,Corrado Pelaia et al.
Nadia Lobello et al.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease associated with epithelial dysfunction and impaired mucosal barrier integrity. Dupilumab, an IL-4 receptor alpha antagonist, has shown clinical efficacy, but...
Mitochondrial dysfunction and oxidative stress in Parkinson's disease: mechanisms, biomarkers, and therapeutic strategies [0.03%]
帕金森病中的线粒体功能障碍与氧化应激：机制、生物标志物和治疗策略
Pothu Usha Kiran,Jigar Haria,Reena Rani et al.
Pothu Usha Kiran et al.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by motor symptoms and progressive degeneration of dopaminergic neurons. Accumulating evidence indicates that mitocho...
Claudins in ovarian cancer: emerging biomarkers and therapeutic targets [0.03%]
Claudin在卵巢癌中的作用：新兴生物标志物和治疗靶点
Lubna Therachiyil,Ajaz A Bhat,Shahab Uddin
Lubna Therachiyil
Tight junctions (TJ) comprise protein complexes that help with the movement of ions and molecules through the paracellular pathway, thus maintaining both epithelial and endothelial integrity. The TJ proteins are diverse and include claudins...
Advanced 3D-Printed hydrogel dressings incorporating platelet-rich plasma for accelerated skin repair [0.03%]
一种用于加速皮肤修复的含富血小板血浆的高级3D打印水凝胶敷料
Carlos de Almeida Barbosa,Luize Kremer Gamba,Rossana B Simeoni et al.
Carlos de Almeida Barbosa et al.
The restoration of cutaneous barrier function following deep skin injury remains a critical challenge in regenerative medicine. In this study, we developed a semi-occlusive wound dressing by combining sodium alginate hydrogel with platelet-...
Concordance of claudin-18.2 expression in biopsy, resection, and recurrent specimens: implications for zolbetuximab therapy in pancreatic ductal adenocarcinoma [0.03%]
内镜活检、手术切除和复发肿瘤组织中CLDN18.2表达一致性：zolbetuximab治疗胰腺导管腺癌的启示
Daisuke Kyuno,Kazuhiko Yanazume,Akira C Saito et al.
Daisuke Kyuno et al.
Claudin-18.2 is a promising therapeutic target for gastrointestinal cancer. However, its expression pattern in pancreatic ductal adenocarcinoma, especially the concordance between biopsy and resection specimens, is unknown. This study aimed...
Effect of local versus systemic exosomes administration on both testes in rat model of testicular ischemic reperfusion injury: shedding light on blood testis barrier [0.03%]
局部与全身外泌体给药对睾丸缺血再灌注损伤模型大鼠双侧睾丸的影响：揭示血液睾丸屏障之光
Manar Fouli Gaber Ibrahim,Elshymaa A Abdel-Hakeem,Heba A Shawky et al.
Manar Fouli Gaber Ibrahim et al.
Exosomes, (EXs) competence in reproductive medicine has been proven, particularly in cases of ischemia reperfusion (IR) injury models. Testicular torsion is a major clinical concern affecting male fertility and results in ischemic reperfusi...
Centella asiatica phytochemical Madecassoside enhances skin wound healing and protects against UVB-induced keratinocyte damage [0.03%]
羟基酸类马黛草素加速皮肤伤口愈合并保护UVB诱导的角质细胞损伤
Tadhi Sucharitakul,Pimngeon Chatkul,Wilasinee Satianrapapong et al.
Tadhi Sucharitakul et al.
Madecassoside, one of the main bioactive compounds found in Centella asiatica extract, has long been used in the cosmetic regime for skin care with doubtful effects. The main objectives of this study are to investigate the effects of Madeca...
Antagonists of the N-cadherin/Fibroblast growth factor receptor tyrosine kinase complex [0.03%]
N-钙黏着蛋白/ fibroblast 溶生长因子受体酪氨酸激酶复合物拮抗剂
Orest W Blaschuk
Orest W Blaschuk
This review describes similarities between the biological actions of cell adhesion molecule antagonists and pan-growth factor receptor tyrosine kinase (GF-RTK) antagonists. In particular, the biological consequences of the interaction betwe...
Involvement of claudins 6 and 9 in epithelial-mesenchymal transition and the metastatic process [0.03%]
Claudin 6和Claudin 9参与上皮间质转化及其促进转移的作用
Naresh E Diego,Luis F Montaño,Erika P Rendon-Huerta
Naresh E Diego
Claudins are essential components of tight junctions, and their abnormal expression is linked to cancer development. Claudin-6 (CLDN6) and Claudin-9 (CLDN9) are claudins whose expression is suppressed post-development but reinduced in vario...