CD73s protection of epithelial integrity: Thinking beyond the barrier [0.03%]
CD73对上皮完整性的保护作用：超越屏障的思考
Jessica L Bowser,Russell R Broaddus
Jessica L Bowser
The prevailing view of CD73 in cancer is that it is overexpressed in tumors and promotes cancer progression by dampening local T cell-mediated immune responses. We recently found that CD73 is down-regulated in poorly-differentiated and adva...
A proposed route to independent measurements of tight junction conductance at discrete cell junctions [0.03%]
一种在离散细胞连接处独立测量紧密连接电导的新方法的研究
Lushan Zhou,Yuhan Zeng,Lane A Baker et al.
Lushan Zhou et al.
Direct recording of tight junction permeability is of pivotal importance to many biologic fields. Previous approaches bear an intrinsic disadvantage due to the difficulty of separating tight junction conductance from nearby membrane conduct...
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target [0.03%]
从基础研究到治疗靶点的肠道屏障功能调节因子ClC-2的研究进展
Younggeon Jin,Anthony T Blikslager
Younggeon Jin
The ClC-2 chloride channel is a member of the voltage-gated chloride channel family. ClC-2 is involved in various physiological processes, including fluid transport and secretion, regulation of cell volume and pH, maintaining the membrane p...