In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis [0.03%]
生死攸关：细胞凋亡如何挑战上皮组织屏障的完整性
Kinga Duszyc,Guillermo A Gomez,Kate Schroder et al.
Kinga Duszyc et al.
Apoptosis is a ubiquitous mode of programmed cell death that is found in healthy organs and can be stimulated by many toxic stresses. When it occurs in epithelia, apoptosis presents major challenges to tissue integrity. Apoptotic corpses ca...
Alan R Parrish
Alan R Parrish
The epithelium has many critical roles in homeostasis, including an essential responsibility in establishing tissue barriers. In addition to the fundamental role in separating internal from external environment, epithelial barriers maintain...
Scaffolding proteins in the development and maintenance of the epidermal permeability barrier [0.03%]
经皮肤屏障发育和维护的支架蛋白
Melissa Crawford,Lina Dagnino
Melissa Crawford
The skin of mammals and other terrestrial vertebrates protects the organism against the external environment, preventing heat, water and electrolyte loss, as well as entry of chemicals and pathogens. Impairments in the epidermal permeabilit...
The barrier hypothesis and Oncostatin M: Restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease [0.03%]
屏障假说和Oncostatin M：恢复上皮屏障功能作为治疗2型炎症性疾病的新策略
Kathryn L Pothoven,Robert P Schleimer
Kathryn L Pothoven
Mucosal epithelium maintains tissue homeostasis through many processes, including epithelial barrier function, which separates the environment from the tissue. The barrier hypothesis of type 2 inflammatory disease postulates that epithelial...
Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin [0.03%]
时间依赖性和剂量依赖性的occludin对生物学功能的贡献：皮肤中occludin-1的启示
Reitaro Tokumasu,Atsushi Tamura,Sachiko Tsukita
Reitaro Tokumasu
There are many types of biologic compartments in the body. Tight junctions (TJs) function to create a dynamic paracellular barrier to separate these compartments and maintain homeostasis. The TJ component claudin-1 is the major transmembran...
The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers [0.03%]
小G蛋白和EPAC-Rap信号在血脑屏障和血视网膜屏障调节中的作用
Carla J Ramos,David A Antonetti
Carla J Ramos
Maintenance and regulation of the vascular endothelial cell junctional complex is critical for proper barrier function of the blood-brain barrier (BBB) and the highly related blood-retinal barrier (BRB) that help maintain proper neuronal en...
Ming-Fang Wu,Chen-Yi Liao,Ling-Yi Wang et al.
Ming-Fang Wu et al.
The role of Slit/Robo signaling has extended from initial axon repulsion in the developing nervous system to organ morphogenesis, cancer development and angiogenesis. Slit/Robo signaling regulates similar pathways within these processes. Sl...
Roles of transient receptor potential channels in regulation of vascular and epithelial barriers [0.03%]
瞬时受体电位通道在血管和上皮屏障调节中的作用
Evan W Weber,William A Muller
Evan W Weber
Transient receptor potential (TRP) channels are a ubiquitously expressed multi-family group of cation channels that are critical to signaling events in many tissues. Their roles have been documented in many physiologic and pathologic condit...
Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions [0.03%]
Claudins蛋白的非经典功能：调控细胞间黏附作用之外的功能
Susan J Hagen
Susan J Hagen
Tight junctions form a barrier to the diffusion of apical and basolateral membrane proteins thus regulating membrane polarity. They also regulate the paracellular movement of ions and water across epithelial and endothelial cells so that fu...
Derek M McKay,Adam Shute,Fernando Lopes
Derek M McKay
Approximately one-sixth of the worlds' population is infected with helminths and this class of parasite takes a major toll on domestic livestock. The majority of species of parasitic helminth that infect mammals live in the gut (the only ni...