The barrier hypothesis and Oncostatin M: Restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease [0.03%]
屏障假说和Oncostatin M：恢复上皮屏障功能作为治疗2型炎症性疾病的新策略
Kathryn L Pothoven,Robert P Schleimer
Kathryn L Pothoven
Mucosal epithelium maintains tissue homeostasis through many processes, including epithelial barrier function, which separates the environment from the tissue. The barrier hypothesis of type 2 inflammatory disease postulates that epithelial...
Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin [0.03%]
时间依赖性和剂量依赖性的occludin对生物学功能的贡献：皮肤中occludin-1的启示
Reitaro Tokumasu,Atsushi Tamura,Sachiko Tsukita
Reitaro Tokumasu
There are many types of biologic compartments in the body. Tight junctions (TJs) function to create a dynamic paracellular barrier to separate these compartments and maintain homeostasis. The TJ component claudin-1 is the major transmembran...
The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers [0.03%]
小G蛋白和EPAC-Rap信号在血脑屏障和血视网膜屏障调节中的作用
Carla J Ramos,David A Antonetti
Carla J Ramos
Maintenance and regulation of the vascular endothelial cell junctional complex is critical for proper barrier function of the blood-brain barrier (BBB) and the highly related blood-retinal barrier (BRB) that help maintain proper neuronal en...
Ming-Fang Wu,Chen-Yi Liao,Ling-Yi Wang et al.
Ming-Fang Wu et al.
The role of Slit/Robo signaling has extended from initial axon repulsion in the developing nervous system to organ morphogenesis, cancer development and angiogenesis. Slit/Robo signaling regulates similar pathways within these processes. Sl...
Roles of transient receptor potential channels in regulation of vascular and epithelial barriers [0.03%]
瞬时受体电位通道在血管和上皮屏障调节中的作用
Evan W Weber,William A Muller
Evan W Weber
Transient receptor potential (TRP) channels are a ubiquitously expressed multi-family group of cation channels that are critical to signaling events in many tissues. Their roles have been documented in many physiologic and pathologic condit...
Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions [0.03%]
Claudins蛋白的非经典功能：调控细胞间黏附作用之外的功能
Susan J Hagen
Susan J Hagen
Tight junctions form a barrier to the diffusion of apical and basolateral membrane proteins thus regulating membrane polarity. They also regulate the paracellular movement of ions and water across epithelial and endothelial cells so that fu...
Derek M McKay,Adam Shute,Fernando Lopes
Derek M McKay
Approximately one-sixth of the worlds' population is infected with helminths and this class of parasite takes a major toll on domestic livestock. The majority of species of parasitic helminth that infect mammals live in the gut (the only ni...
Interactions of Giardia sp. with the intestinal barrier: Epithelium, mucus, and microbiota [0.03%]
兰伯氏贾第虫与肠屏障的相互作用：上皮细胞、粘液和微生物群
Thibault Allain,Christina B Amat,Jean-Paul Motta et al.
Thibault Allain et al.
Understanding how intestinal enteropathogens cause acute and chronic alterations has direct animal and human health perspectives. Significant advances have been made on this field by studies focusing on the dynamic crosstalk between the int...
Mark R Gillrie,May Ho
Mark R Gillrie
Plasmodial species are protozoan parasites that infect erythrocytes. As such, they are in close contact with microvascular endothelium for most of the life cycle in the mammalian host. The host-parasite interactions of this stage of the inf...
Mechanisms and pathways of Toxoplasma gondii transepithelial migration [0.03%]
Toxoplasma gondii上皮细胞迁移的机制和途径
Emily J Jones,Tamas Korcsmaros,Simon R Carding
Emily J Jones
Toxoplasma gondii is a ubiquitous parasite and a prevalent food-borne parasitic pathogen. Infection of the host occurs principally through oral consumption of contaminated food and water with the gastrointestinal tract being the primary rou...