Arivarasu N Anbazhagan,Shubha Priyamvada,Waddah A Alrefai et al.
Arivarasu N Anbazhagan et al.
Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing prevalence worldwide. The etiology of the disease is com...
Extracellular vesicles regulate immune responses and cellular function in intestinal inflammation and repair [0.03%]
细胞外囊泡调节肠道炎症和修复中的免疫反应和细胞功能
Triet M Bui,Lorraine A Mascarenhas,Ronen Sumagin
Triet M Bui
Tightly controlled communication among the various resident and recruited cells in the intestinal tissue is critical for maintaining tissue homeostasis, re-establishment of the barrier function and healing responses following injury. Emergi...
Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects [0.03%]
姜黄素介导的肠屏障功能调节：其有益作用的机制
Siddhartha S Ghosh,Hongliang He,Jing Wang et al.
Siddhartha S Ghosh et al.
Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative properties established largely by in vitro studies. Accordingly, oral administration of curcumin beneficially modulates many diseases including diabetes, fatty-liver diseas...
Lorenza González-Mariscal,Arturo Raya-Sandino,Laura González-González et al.
Lorenza González-Mariscal et al.
Tight junctions (TJs) are sites of cell-cell adhesion, constituted by a cytoplasmic plaque of molecules linked to integral proteins that form a network of strands around epithelial and endothelial cells at the uppermost portion of the later...
Bridging the gap: Super-resolution microscopy of epithelial cell junctions [0.03%]
超分辨率显微镜技术在上皮细胞连接中的应用与发展
Emily I Bartle,Tejeshwar C Rao,Tara M Urner et al.
Emily I Bartle et al.
Cell junctions are critical for cell adhesion and communication in epithelial tissues. It is evident that the cellular distribution, size, and architecture of cell junctions play a vital role in regulating function. These details of junctio...
Characterization of cell-cell junction changes associated with the formation of a strong endothelial barrier [0.03%]
与强内皮屏障形成相关的细胞间连接变化的特征分析
MaryPeace McRae,Lindsay M LaFratta,Benjamin M Nguyen et al.
MaryPeace McRae et al.
A principal function of endothelial cells is the formation of a barrier between the blood and tissues. This barrier arises from the physical connections at cell-cell junctions, which includes cytoskeletal tight junction and adherens junctio...
Maternal-fetal transmission of the zika virus: An intriguing interplay [0.03%]
寨卡病毒的母婴传播：一个令人着迷的相互作用机制
Camila Zanluca,Lucia de Noronha,Claudia Nunes Duarte Dos Santos
Camila Zanluca
In this review, we give an overview of aspects related to the congenital transmission of the Zika virus (ZIKV). Although we acknowledge that important advances in research on ZIKV pathogenesis have come from studies using animal models, par...
Building barriers [0.03%]
筑墙之战
Kursad Turksen
Kursad Turksen
Formation of tissue barriers starts in early development where it is critical for normal cell fate selection, differentiation and organogenesis. Barrier maintenance is critical to the ongoing function of organs during adulthood and aging. D...
Pratap Karki,Konstantin G Birukov
Pratap Karki
Lipid mediators play a critical role in the development and resolution of vascular endothelial barrier dysfunction caused by various pathologic interventions. The accumulation of excess lipids directly impairs endothelial cell (EC) barrier ...
Phosphorylation of tight junction transmembrane proteins: Many sites, much to do [0.03%]
紧密连接跨膜蛋白的磷酸化：多个位点，多种功能
Christina M Van Itallie,James M Anderson
Christina M Van Itallie
Phosphorylation is a dynamic post-translational modification that can alter protein structure, localization, protein-protein interactions and stability. All of the identified tight junction transmembrane proteins can be multiply phosphoryla...