Mohammad A Uddin,Mohammad S Akhter,Sitanshu S Singh et al.
Mohammad A Uddin et al.
Growth Hormone-Releasing Hormone (GHRH) regulates the release of growth hormone from the anterior pituitary gland. GHRH also acts as a growth and inflammatory factor in a variety of experimental models in oncology. In the current study, we ...
The extracellular matrix of the blood-brain barrier: structural and functional roles in health, aging, and Alzheimer's disease [0.03%]
血脑屏障的细胞外基质：其在健康、衰老和阿尔茨海默病中的结构及功能作用
May J Reed,Mamatha Damodarasamy,William A Banks
May J Reed
There is increasing interest in defining the location, content, and role of extracellular matrix (ECM) components in brain structure and function during development, aging, injury, and neurodegeneration. Studies in vivo confirm brain ECM ha...
Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure [0.03%]
地塞米松暴露下Caco-2单层细胞30天时间线上差异基因表达和基因集富集分析
J M Robinson,S Turkington,S A Abey et al.
J M Robinson et al.
Glucocorticoid hormones affect gene expression via activation of glucocorticoid receptor NR3C1, causing modulation of inflammation and autoimmune activation. The glucocorticoid Dexamethasone is an important pharmaceutical for the treatment ...
R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing [0.03%]
R40.76与ZO-1α结构域结合：具有ZO-1（α+）上皮分化和机械感受的作用
Florian Rouaud,Ekaterina Vasileva,Domenica Spadaro et al.
Florian Rouaud et al.
The barrier function of epithelia and endothelia depends on tight junctions, which are formed by the polymerization of claudins on a scaffold of ZO proteins. Two differentially spliced isoforms of ZO-1 have been described, depending on the ...
Gingival epithelial barrier: regulation by beneficial and harmful microbes [0.03%]
牙龈上皮屏障：有益菌和有害菌的调节作用
Naoki Takahashi,Benso Sulijaya,Miki Yamada-Hara et al.
Naoki Takahashi et al.
The gingival epithelium acts as a physical barrier to separate the biofilm from the gingival tissue, providing the first line of defense against bacterial invasion in periodontal disease. Disruption of the gingival epithelial barrier, and t...
Gingival epithelial barrier: regulation by beneficial and harmful microbes [0.03%]
牙龈上皮屏障：有益和有害微生物的调节作用
Naoki Takahashi,Benso Sulijaya,Miki Yamada-Hara et al.
Naoki Takahashi et al.
The gingival epithelium acts as a physical barrier to separate the biofilm from the gingival tissue, providing the first line of defense against bacterial invasion in periodontal disease. Disruption of the gingival epithelial barrier, and t...
" Candida Albicans Interactions With The Host: Crossing The Intestinal Epithelial Barrier" [0.03%]
白色念珠菌与宿主的相互作用：穿越肠上皮屏障
Louise Basmaciyan,Fabienne Bon,Tracy Paradis et al.
Louise Basmaciyan et al.
Formerly a commensal organism of the mucosal surfaces of most healthy individuals, Candida albicans is an opportunistic pathogen that causes infections ranging from superficial to the more life-threatening disseminated infections, especiall...
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage [0.03%]
occludin敲除不足以诱导经上皮大分子物质通透性增加
Jan F Richter,Markus Hildner,Ralf Schmauder et al.
Jan F Richter et al.
Occludin, a tight junction protein, has been reported to regulate barrier function - particularly the leak pathway for larger solutes - in epithelia. Therefore, we aimed to precisely define its role in macromolecule passage at single cell-c...
Probing paracellular - versus transcellular tissue barrier permeability using a gut mucosal explant culture system [0.03%]
采用肠道黏膜组织切片培养系统研究经细胞旁路和细胞内的屏障通透性
E Michael Danielsen,Gert H Hansen
E Michael Danielsen
Intestinal permeation enhancers (PEs), i.e. agents improving oral delivery of therapeutic drugs with poor bioavailability, may typically act by two principally different mechanisms: to increase either transcellular -or paracellular passage ...
Chloride intracellular channel protein 2 in cancer and non-cancer human tissues: relationship with tight junctions [0.03%]
氯离子细胞内通道蛋白2在正常和肿瘤组织中的表达及其与紧密连接的关系研究
Yoshitomo Ueno,Saya Ozaki,Akihiro Umakoshi et al.
Yoshitomo Ueno et al.
Chloride intracellular channel protein 2 (CLIC2) belongs to the CLIC family of conserved metazoan proteins. Although CLICs have been identified as chloride channels, they are currently considered multifunctional proteins. CLIC2 is the least...