Yosuke Ishitsuka,Dennis R Roop,Tatsuya Ogawa
Yosuke Ishitsuka
Keratinization provides tolerance to desiccation and mechanical durability. Loricrin, which is an epidermal thiol-rich protein, efficiently stabilizes terminally differentiated keratinocytes and maintains redox homeostasis. The discovery of...
Basic physiology of the blood-brain barrier in health and disease: a brief overview [0.03%]
健康与疾病状态下的血脑屏障基本生理概述
Mehmet Kaya,Bulent Ahishali
Mehmet Kaya
The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially harmful blood-sourced substances and cells into the brain,...
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model [0.03%]
环境压力影响猪肠缺血模型中的肠道渗透性和修复反应
Amanda L Ziegler,Tiffany A Pridgen,Anthony T Blikslager
Amanda L Ziegler
The pig is a powerful model for intestinal barrier studies, and it is important to carefully plan animal care and handling for optimal study design as psychological and physiological stressors significantly impact intestinal mucosal barrier...
The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption [0.03%]
肠道群体感应分子3-oxo-C12:2酰基霍姆塞因内酯限制了细胞因子诱导的紧密连接破坏
Doriane Aguanno,Garance Coquant,Barbara G Postal et al.
Doriane Aguanno et al.
The intestine is home to the largest microbiota community of the human body and strictly regulates its barrier function. Tight junctions (TJ) are major actors of the intestinal barrier, which is impaired in inflammatory bowel disease (IBD),...
Joseph M Chambers,Rebecca A Wingert
Joseph M Chambers
The kidney is a complex organ that performs essential functions such as blood filtration and fluid homeostasis, among others. Recent years have heralded significant advancements in our knowledge of the mechanisms that control kidney formati...
HMGB1 enhances epithelial permeability via p63/TGF-β signaling in lung and terminal bronchial epithelial cells [0.03%]
HMGB1通过p63/TGF-β信号通路增强肺和终末支气管上皮细胞的上皮通透性
Yuki Kodera,Takayuki Kohno,Takumi Konno et al.
Yuki Kodera et al.
High mobility group box 1 (HMGB1) is involved in the induction of airway inflammation and injury in patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). HMGB1 increased by transforming growth f...
Kim Natalie Stolte,Carsten Pelz,Cynthia V Yapto et al.
Kim Natalie Stolte et al.
Periodontitis is one of the most common oral diseases worldwide and is caused by a variety of interactions between oral bacteria and the host. Here, pathogens induce inflammatory host responses that cause the secretion of proinflammatory cy...
Correction [0.03%]
改正
Published Erratum
Tissue barriers. 2020 Apr 2;8(2):1784644. DOI:10.1080/21688370.2020.1784644 2020
Distribution pattern of ZO-1 and claudins in the epididymis of vampire bats [0.03%]
吸血蝙蝠附睾中ZO-1和claudins的分布模式
Mariana M Castro,Bongki Kim,Patrícia D Games et al.
Mariana M Castro et al.
Epithelial cells connect with each other by tight junctions (TJs) in several tissues. In epididymides, TJs proteins form the blood-epididymis barrier (BEB), which is crucial for male fertility. However, little is known about BEB morphologic...
DRM02, a novel phosphodiesterase-4 inhibitor with cutaneous anti-inflammatory activity [0.03%]
一种具有皮肤抗炎活性的新磷酸二酯酶-4抑制剂DRM02
David W C Hunt,Iordanka A Ivanova,Lina Dagnino
David W C Hunt
Chronic inflammatory skin disorders are frequently associated with impaired skin barrier function. Selective phosphodiesterase-4 (PDE4) inhibition constitutes an effective therapeutic strategy for the treatment of inflammatory skin diseases...