Protective activity of bacopaside I encapsulated polymeric nanoparticles against kainic acid-induced excitotoxicity [0.03%]
bacopaside I包封聚合物纳米粒对氯胺酮诱导的小鼠幻听的干预作用研究
Vini C Sekhar,Sabulal Baby,Prabath Gopalakrishnan Biju et al.
Vini C Sekhar et al.
Bacopaside I (BM4), a saponin found in Bacopa monnieri, has nootropic, neuroprotective, and anti-depressant properties. Neuroprotective entities generally are impermeable across the brain membrane, and this hassle can be resolved by using d...
Cannabinoid/lysophosphatidylinositol-sensing G-protein coupled receptor 55 promotes intestinal tight junction assembly and its mechanistic insights [0.03%]
大麻素/溶血磷脂酰肌醇感受G蛋白偶联受体GPR55促进肠道紧密连接的形成及其机制研究
Supisara Treveeravoot,Pichayapa Sukmak,Pimngeon Chatkul et al.
Supisara Treveeravoot et al.
Intestinal tight junction disruption initiates progression of related diseases including inflammatory bowel disease (IBD) with no FDA-approved drug for tight junction recovery. To demonstrate the effect of pharmacological activation of the ...
Robust paraffin embedding of 3D cultured vocal fold epithelial organoids [0.03%]
适用于声带器官型类器官的石蜡包埋方法优化研究
Yun-Lan Yi,Hong Zhang,Ying-Ying Wang et al.
Yun-Lan Yi et al.
Vocal fold organoids recapitulate critical structural and functional features of native vocal fold mucosa, providing a physiologically relevant model for investigating vocal fold biology and disease mechanisms. However, conventional histolo...
Involvement of cellular and enzymatic aspects in the complexity of diabetic neuropathy [0.03%]
糖尿病神经病变的复杂性与细胞和酶学的关系
Anjali Gupta,Tanya Gupta,Thakur Gurjeet Singh et al.
Anjali Gupta et al.
Diabetic neuropathy (DN) is a multifaceted and progressive complication of diabetes mellitus, characterized by functional and structural damage to peripheral, autonomic, and sensory nerves. Despite its high prevalence and debilitating conse...
Structural and functional insights of the podocyte slit diaphragm complex [0.03%]
足细胞裂孔隔膜复合物的结构与功能新见解
Abrar H Qadri,Jyotsana Prajapati,Dagumati Praghna et al.
Abrar H Qadri et al.
Glomerular podocytes, specialized epithelial cells, are central to the filtration function of vertebrate kidneys. Through their interdigitating foot processes, podocytes provide epithelial coverage to capillaries. They maintain selective fi...
Selenium nanoparticles ameliorate methotrexate-induced gastric fundus injury in adult male albino rats via TLR4/NF-κB signaling, apoptosis, and intercellular junctions modulation: biochemical and histological study [0.03%]
硒纳米颗粒通过TLR4/NF-κB信号传导、凋亡和细胞间连接调节改善异株鼠类成年雄性斑鼠甲氨蝶呤所致胃底损伤：生化和组织学研究
Sahar A Mokhemer,Esraa Mohammed Khairy,Rehab Ahmed Rifaai et al.
Sahar A Mokhemer et al.
Despite its widespread application in the treatment of cancer and autoimmune diseases, methotrexate (MTX) is associated with several adverse effects. Selenium nanoparticles (SeNPs) have antioxidant and anti-inflammatory effects. This study ...
Influence of Alzheimer's associated Aβ oligomers and oxidative stress on blood-brain barrier dysfunction [0.03%]
阿尔茨海默病相关Aβ寡聚体和氧化应激对血脑屏障功能障碍的影响
Brittany E Watson,Mihyun L Waugh,Nolan J Foreman et al.
Brittany E Watson et al.
Blood-brain barrier (BBB) dysfunction is an early event observed in Alzheimer's disease (AD). Two characteristics of AD brain and brain vasculature contribute to BBB dysfunction: the accumulation of aggregated amyloid-β protein (Aβ) and a...
Apoorva,Sunit K Singh
Apoorva
Blood-tissue barriers (BTBs) are highly specialized, selectively permeable surfaces that separate the circulatory system from delicate tissues and organs. Critical examples include the blood-brain barrier (BBB), blood-retinal barrier (BRB),...
Patient-derived 3D nasal spheroids reveal epithelial changes following Dupilumab therapy in CRSwNP: a preliminary report [0.03%]
基于患者的3D鼻球体模型揭示了Dupilumab治疗CRSwNP后的上皮变化：初步报告
Nadia Lobello,Giovanna Lucia Piazzetta,Corrado Pelaia et al.
Nadia Lobello et al.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease associated with epithelial dysfunction and impaired mucosal barrier integrity. Dupilumab, an IL-4 receptor alpha antagonist, has shown clinical efficacy, but...
Mitochondrial dysfunction and oxidative stress in Parkinson's disease: mechanisms, biomarkers, and therapeutic strategies [0.03%]
帕金森病中的线粒体功能障碍与氧化应激：机制、生物标志物和治疗策略
Pothu Usha Kiran,Jigar Haria,Reena Rani et al.
Pothu Usha Kiran et al.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by motor symptoms and progressive degeneration of dopaminergic neurons. Accumulating evidence indicates that mitocho...