Kotaro Sugimoto,Hideki Chiba
Kotaro Sugimoto
Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The ...
RNA-binding proteins and long noncoding RNAs in intestinal epithelial autophagy and barrier function [0.03%]
肠道上皮自噬和屏障功能中的rna结合蛋白和长链非编码rna
Lan Xiao,Jaladanki N Rao,Jian-Ying Wang
Lan Xiao
The intestinal autophagy and barrier function are crucial for maintaining the epithelium homeostasis and tightly regulated through well-controlled mechanisms. RNA-binding proteins (RBPs) and long noncoding RNAs (lncRNAs) modulate gene expre...
Pyk2 inhibitor prevents epithelial hyperpermeability induced by HMGB1 and inflammatory cytokines in Caco-2 cells [0.03%]
Pyk2抑制剂预防HMGB1和炎症细胞因子诱导的Caco-2细胞上皮屏障功能障碍
Takumi Konno,Takayuki Kohno,Maki Miyakawa et al.
Takumi Konno et al.
The non-receptor protein tyrosine kinase 2β (Pyk2) phosphorylated tricellular tight junction (tTJ) molecules angulin-1/LSR and tricellulin (TRIC) and the inhibitor PF-431396 (PF43) suppress angulin-1/LSR and TRIC recruitment to tTJs. The d...
Quercetin: a savior of alveolar barrier integrity under hypoxic microenvironment [0.03%]
缺氧微环境下檞皮素对肺泡屏障完整性的保护作用研究
Ankit Tripathi,Puja P Hazari,Anil K Mishra et al.
Ankit Tripathi et al.
High altitude pulmonary edema (HAPE) is generally characterized by the loss of alveolar epithelial barrier integrity. The current study was undertaken to assess the noninvasive approaches of HAPE diagnosis and to evaluate the prophylactic p...
Debra T Linfield,Andjela Raduka,Mahyar Aghapour et al.
Debra T Linfield et al.
The apical junctional complexes (AJCs) of airway epithelial cells are a key component of the innate immune system by creating barriers to pathogens, inhaled allergens, and environmental particles. AJCs form between adjacent cells and consis...
Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells [0.03%]
感染模拟物会破坏人脑内皮细胞中多药耐药转运蛋白的功能
Guinever Eustaquio Do Imperio,Phetcharawan Lye,Enrrico Bloise et al.
Guinever Eustaquio Do Imperio et al.
P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) modulate the distribution of drugs and toxins across the blood-brain barrier (BBB). Animal studies reported that infection-induced disruption of these transporter...
Ovariectomized mice and postmenopausal women exhibit analogous loss of genital epithelial integrity [0.03%]
卵巢切除的小鼠和绝经后的女性生殖道上皮屏障功能损伤表型类似
Nirk E Quispe Calla,Rodolfo D Vicetti Miguel,Kristen M Aceves et al.
Nirk E Quispe Calla et al.
Roughly half of all postmenopausal women are affected by the genitourinary syndrome of menopause (GSM). Symptoms of GSM, including vaginal irritation and dyspareunia, occur as reduced estrogen (E) production elicits loss of elasticity and o...
Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells [0.03%]
p53和肠上皮细胞核因子4α反向调节结肠MCE301细胞中 Claudin-2和Claudin-7的表达
Chieko Hirota,Yui Takashina,Naotaka Ikumi et al.
Chieko Hirota et al.
Colonic epithelial cells move up along the crypt villus axis and are differentiated into absorptive or secretory cells. Claudin-7 (CLDN7), a tight junctional protein, is mainly located at the surface of crypt, whereas CLDN2 is located at th...
Tatiana Barichello,Jaqueline S Generoso,Allan Collodel et al.
Tatiana Barichello et al.
Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host immune response attempting to eliminate the infection. After hospital discharge, half of the sepsis survivors recover, one-third of the patients die the followi...
Mir S Adil,S Priya Narayanan,Payaningal R Somanath
Mir S Adil
Epithelial and endothelial cell-cell contacts are established and maintained by several intercellular junctional complexes. These structurally and biochemically differentiated regions on the plasma membrane primarily include tight junctions...