Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials [0.03%]
Claudin-18.2在癌症中的治疗作用及基础与临床研究累积证据
Daisuke Kyuno,Akira Takasawa,Kumi Takasawa et al.
Daisuke Kyuno et al.
Claudins are major components of tight junctions that maintain cell polarity and intercellular adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic target. During carcinogenesis, claudin expression is...
E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease [0.03%]
靶向活化E-钙粘蛋白的抗体能够减轻小鼠炎症性肠病中的屏障损伤和炎症反应
Chirosree Bandyopadhyay,Leslayann Schecterson,Barry M Gumbiner
Chirosree Bandyopadhyay
Deficits in gastrointestinal (GI) paracellular permeability has been implicated in etiology of Inflammatory Bowel Disease (IBD), and E-cadherin, a key component of the epithelial junctional complex, has been implicated in both barrier funct...
Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs [0.03%]
细胞穿透肽改善抗癌药物的药代动力学和药效学
Izabela Rusiecka,Iwona Gągało,Ivan Kocić
Izabela Rusiecka
This review concentrates on the research concerning conjugates of anticancer drugs with versatile cell-penetrating peptides (CPPs). For a better insight into the relationship between the components of the constructs, it starts with the char...
The role of connexins in breast cancer: from misregulated cell communication to aberrant intracellular signaling [0.03%]
缝隙连接蛋白在乳腺癌中的作用：从细胞间通讯失调到异常的胞内信号转导
Yagmur Ceren Unal,Busra Yavuz,Engin Ozcivici et al.
Yagmur Ceren Unal et al.
In spite of clinical advancements and improved diagnostic techniques, breast cancers are the leading cause of cancer-associated deaths in women worldwide. Although 70% of early breast cancers can be cured, there are no efficient therapies a...
Rivaroxaban protects from the oxysterol-induced damage and inflammatory activation of the vascular endothelium [0.03%]
瑞洛-xlaz帕 XFONAN 克抑制氧化固醇所致血管内皮细胞损伤和激活
Paulina Gorzelak-Pabis,Marlena Broncel,Katarzyna Wojdan et al.
Paulina Gorzelak-Pabis et al.
Background: Rivaroxaban is one of the direct factor Xa inhibitors. Its function in the inactivated coagulation cascade is unclear. The aim of the study was to assess the effect of rivaroxaban on the endothelial integrity ...
Effect of Adipose derived mesenchymal stem cells on multiple Organ Injuries in diet-induced obese mice [0.03%]
饮食诱导的肥胖小鼠脂肪来源间充质干细胞对多器官损伤的影响
Fatima A Saleh,Hala Jaber,Ali Eid
Fatima A Saleh
Background: Obesity is a complex disease involving the accumulation of body fat that can inflict a substantial risk to health due to the potent role it plays in the development of a series of chronic diseases including cardiovascular diseas...
Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD [0.03%]
肠道菌群及其代谢产物在非酒精性脂肪性肝病胃肠道屏障功能中的作用
Maria Victoria Fernandez-Cantos,Diego Garcia-Morena,Valeria Iannone et al.
Maria Victoria Fernandez-Cantos et al.
The Gastrointestinal (GI) tract is composed of four main barriers: microbiological, chemical, physical and immunological. These barriers play important roles in maintaining GI tract homeostasis. In the crosstalk between these barriers, micr...
Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread [0.03%]
病毒相关黏膜上皮紧密连接的破坏及其在病毒传播中的作用
Sharof Tugizov
Sharof Tugizov
Oropharyngeal, airway, intestinal, and genital mucosal epithelia are the main portals of entry for the majority of human pathogenic viruses. To initiate systemic infection, viruses must first be transmitted across the mucosal epithelium and...
The blood-gas barrier in COVID-19: an overview of the effects of SARS-CoV-2 infection on the alveolar epithelial and endothelial cells of the lung [0.03%]
COVID-19的气血屏障：SARS-CoV-2感染对肺泡上皮细胞和内皮细胞影响概述
Milad Shirvaliloo
Milad Shirvaliloo
Blood-gas barrier (BGB) or alveolar-capillary barrier is the primary tissue barrier affected by coronavirus disease 2019 (COVID-19). Comprising alveolar epithelial cells (AECs), endothelial cells (ECs) and the extracellular matrix (ECM) in ...
Anaclet Ngezahayo,Frederike A Ruhe
Anaclet Ngezahayo
Connexins (Cxs) form gap junction (GJ) channels linking vertebrate cells. During embryogenesis, Cxs are expressed as early as the 4-8 cell stage. As cells differentiate into pluripotent stem cells (PSCs) and during gastrulation, the Cx expr...