Desmosomes undergo dynamic architectural changes during assembly and maturation [0.03%]
黏合带在组装和成熟过程中会经历动态的结构变化
Reena R Beggs,Tejeshwar C Rao,William F Dean et al.
Reena R Beggs et al.
Desmosomes are macromolecular cell-cell junctions critical for maintaining adhesion and resisting mechanical stress in epithelial tissue. Desmosome assembly and the relationship between maturity and molecular architecture are not well under...
Metformin-dependent variation of microglia phenotype dictates pericytes maturation under oxygen-glucose deprivation [0.03%]
metformin依赖的微胶质细胞表型变化决定氧糖剥夺下的周细胞成熟度
Mohammad Hossein Geranmayeh,Reza Rahbarghazi,Nazli Saeedi et al.
Mohammad Hossein Geranmayeh et al.
Blood-brain barrier resident cells are in the frontline of vascular diseases. To maintain brain tissue homeostasis, a series of cells are integrated regularly to form the neurovascular unit. It is thought that microglia can switch between M...
Destiny of airway disease: interplay between epithelial barrier and the innate immune system [0.03%]
气道疾病的发生发展：上皮屏障与固有免疫系统的相互作用
Hasan Yüksel,Seda Tunca
Hasan Yüksel
When the organism encounters a foreign substance, it responds with mutual and regular interactions at different stages of the immune system. In airway diseases, the first encounter is at the epithelial level, where innate immune cells and t...
Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting [0.03%]
细菌外排系统作为抗菌剂的屏障：结构生物学方面及药物靶向作用
Pownraj Brindangnanam,Ajit Ramesh Sawant,K Prashanth et al.
Pownraj Brindangnanam et al.
Antimicrobial resistance (AMR) is fast becoming a medical crisis affecting the entire global population. The bacterial membrane is the first layer of defense for the bacteria against antimicrobial agents (AMA), specifically transporters in ...
Coenzyme Q10 protects against doxorubicin-induced cardiomyopathy via antioxidant and anti-apoptotic pathway [0.03%]
辅酶Q10通过抗氧化和抗凋亡通路保护多柔比星致心肌病的作用研究
Dalia A Shabaan,Nora Mostafa,Manal M El-Desoky et al.
Dalia A Shabaan et al.
Doxorubicin (Dox) is an anthracycline antibiotic that treats a variety of malignancies. Unfortunately, its cardiotoxicity limits its therapeutic usefulness. Coenzyme Q10 (CoQ10) has effectively treated and prevented various cardiac diseases...
Cell penetrating peptides coupled to an endothelial nitric oxide synthase sequence alter endothelial permeability [0.03%]
细胞穿膜肽与内皮型一氧化氮合酶序列结合可改变内皮通透性
Stephen R Koch,Ryan J Stark
Stephen R Koch
Delivery of cargo to cells through the use of cell-penetrating peptide (CPP) sequences is an area of rich investigation for targeted therapeutics. Specific to the endothelium, the layer of cells that cover every blood vessel in the body, th...
Svetlana N Rubtsova,Irina Y Zhitnyak,Natalya A Gloushankova
Svetlana N Rubtsova
E-cadherin is the main component of epithelial adherens junctions (AJs), which play a crucial role in the maintenance of stable cell-cell adhesion and overall tissue integrity. Down-regulation of E-cadherin expression has been found in many...
The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota [0.03%]
zonulin转基因小鼠显示出可通过耗竭肠道微生物群来改善的行为改变
Alba Miranda-Ribera,Gloria Serena,Jundi Liu et al.
Alba Miranda-Ribera et al.
The gut-brain axis hypothesis suggests that interactions in the intestinal milieu are critically involved in regulating brain function. Several studies point to a gut-microbiota-brain connection linking an impaired intestinal barrier and al...
Bioinformatics analyses reveal cell-barrier junction modulations in lung epithelial cells on SARS-CoV-2 infection [0.03%]
生物信息学分析揭示SARS-CoV-2感染对肺上皮细胞中细胞-屏障连接的调节作用
Mir S Adil,Daulat Khulood,S Priya Narayanan et al.
Mir S Adil et al.
Cell junctions maintain the blood-tissue barriers to preserve vascular and tissue integrity. Viral infections reportedly modulate cell-cell junctions to facilitate their invasion. However, information on the effect of COVID-19 infection on ...
Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions [0.03%]
上皮完整性、连接复合体及与肠道功能相关的生物标志物
Arash Alizadeh,Peyman Akbari,Johan Garssen et al.
Arash Alizadeh et al.
An intact intestinal barrier is crucial for immune homeostasis and its impairment activates the immune system and may result in chronic inflammation. The epithelial cells of the intestinal barrier are connected by tight junctions, which for...