Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting [0.03%]
细菌外排系统作为抗菌剂的屏障：结构生物学方面及药物靶向作用
Pownraj Brindangnanam,Ajit Ramesh Sawant,K Prashanth et al.
Pownraj Brindangnanam et al.
Antimicrobial resistance (AMR) is fast becoming a medical crisis affecting the entire global population. The bacterial membrane is the first layer of defense for the bacteria against antimicrobial agents (AMA), specifically transporters in ...
Coenzyme Q10 protects against doxorubicin-induced cardiomyopathy via antioxidant and anti-apoptotic pathway [0.03%]
辅酶Q10通过抗氧化和抗凋亡通路保护多柔比星致心肌病的作用研究
Dalia A Shabaan,Nora Mostafa,Manal M El-Desoky et al.
Dalia A Shabaan et al.
Doxorubicin (Dox) is an anthracycline antibiotic that treats a variety of malignancies. Unfortunately, its cardiotoxicity limits its therapeutic usefulness. Coenzyme Q10 (CoQ10) has effectively treated and prevented various cardiac diseases...
Cell penetrating peptides coupled to an endothelial nitric oxide synthase sequence alter endothelial permeability [0.03%]
细胞穿膜肽与内皮型一氧化氮合酶序列结合可改变内皮通透性
Stephen R Koch,Ryan J Stark
Stephen R Koch
Delivery of cargo to cells through the use of cell-penetrating peptide (CPP) sequences is an area of rich investigation for targeted therapeutics. Specific to the endothelium, the layer of cells that cover every blood vessel in the body, th...
Svetlana N Rubtsova,Irina Y Zhitnyak,Natalya A Gloushankova
Svetlana N Rubtsova
E-cadherin is the main component of epithelial adherens junctions (AJs), which play a crucial role in the maintenance of stable cell-cell adhesion and overall tissue integrity. Down-regulation of E-cadherin expression has been found in many...
The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota [0.03%]
zonulin转基因小鼠显示出可通过耗竭肠道微生物群来改善的行为改变
Alba Miranda-Ribera,Gloria Serena,Jundi Liu et al.
Alba Miranda-Ribera et al.
The gut-brain axis hypothesis suggests that interactions in the intestinal milieu are critically involved in regulating brain function. Several studies point to a gut-microbiota-brain connection linking an impaired intestinal barrier and al...
Bioinformatics analyses reveal cell-barrier junction modulations in lung epithelial cells on SARS-CoV-2 infection [0.03%]
生物信息学分析揭示SARS-CoV-2感染对肺上皮细胞中细胞-屏障连接的调节作用
Mir S Adil,Daulat Khulood,S Priya Narayanan et al.
Mir S Adil et al.
Cell junctions maintain the blood-tissue barriers to preserve vascular and tissue integrity. Viral infections reportedly modulate cell-cell junctions to facilitate their invasion. However, information on the effect of COVID-19 infection on ...
Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions [0.03%]
上皮完整性、连接复合体及与肠道功能相关的生物标志物
Arash Alizadeh,Peyman Akbari,Johan Garssen et al.
Arash Alizadeh et al.
An intact intestinal barrier is crucial for immune homeostasis and its impairment activates the immune system and may result in chronic inflammation. The epithelial cells of the intestinal barrier are connected by tight junctions, which for...
MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model [0.03%]
来自人类异种移植小鼠模型的肠 Fistulas 的 MMP9 表达来自患有瘘管型 CD 的患者
Céline Mamie,Ramona S Bruckner,Silvia Lang et al.
Céline Mamie et al.
Fistula treatment represents a major unmet medical need in the therapy of Crohn's disease (CD). Current medical therapies, such as anti-TNF antibody treatments, are often insufficient and do not achieve permanent fistula closure. Previously...
Biotherapeutic effect of cell-penetrating peptides against microbial agents: a review [0.03%]
穿膜肽对微生物剂的生物治疗作用：一项综述
Idris Zubairu Sadiq,Aliyu Muhammad,Sanusi Bello Mada et al.
Idris Zubairu Sadiq et al.
Selective permeability of biological membranes represents a significant barrier to the delivery of therapeutic substances into both microorganisms and mammalian cells, restricting the access of drugs into intracellular pathogens. Cell-penet...
Urinary IgG, serum CX3CL1 and miRNA-152-3p: as predictors of nephropathy in Egyptian type 2 diabetic patients [0.03%]
尿IgG，血清CX3CL1和miRNA-152-3p：作为埃及二型糖尿病患者肾病的预测因子
Aml E Abdou,Haneya A A Anani,Hanan F Ibrahim et al.
Aml E Abdou et al.
The purpose of this study was to assess the role of urinary IgG, serum CX3CL1 and miRNA 152-3p levels as predictors of nephropathy in type 2 Egyptian diabetic patients. Sixty type 2 diabetic patients and twenty healthy controls were enrolle...