Yogurt starter strains ameliorate intestinal barrier dysfunction via activating AMPK in Caco-2 cells [0.03%]
益生菌通过活化AMPK改善肠上皮细胞屏障功能损伤
Kyosuke Kobayashi,Junko Mochizuki,Fuka Yamazaki et al.
Kyosuke Kobayashi et al.
Lactic acid bacteria (LAB) are commonly used probiotics that improve human health in various aspects. We previously reported that yogurt starter strains, Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131, ...
Matrix metalloproteinase-7 and claudin-7 as novel identified therapeutic targets for restoration of intestinal epithelial barrier in inflammatory bowel diseases [0.03%]
基质金属蛋白酶-7和闭合蛋白-7作为炎症性肠病上皮屏障修复的新治疗靶点
Sunisa Hankan,Pawin Pongkorpsakol
Sunisa Hankan
Intestinal tight junction disruption and mucosal immune dysregulation contribute to pathogenesis and progression of inflammatory bowel diseases (IBD). A proteolytic enzyme matrix metalloproteinase 7 (MMP-7), which is highly expressed in int...
A comprehensive overview of advanced dynamic in vitro intestinal and hepatic cell culture models [0.03%]
高级动态体外肠道和肝细胞培养模型的全面概述
Filipa Leal,Scarlett Zeiringer,Ramona Jeitler et al.
Filipa Leal et al.
Orally administered drugs pass through the gastrointestinal tract before being absorbed in the small intestine and metabolised in the liver. To test the efficacy and toxicity of drugs, animal models are often employed; however, they are not...
Hélène Bonnet,Carlos Agustin Isidro Alonso,Indra R Gupta
Hélène Bonnet
Salivary glands consist of highly specialized epithelial cells that secrete the fluid, saliva, and/or transport saliva into the oral cavity. Saliva is essential to lubricate the oral cavity for food consumption and to maintain the hygiene o...
Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC pathology [0.03%]
产前解脲支原体感染诱导羊小肠杯状细胞缺陷：与NEC病理有很强的联系
Charlotte van Gorp,Ilse H de Lange,Matthias C Hütten et al.
Charlotte van Gorp et al.
Disruption of the intestinal mucus barrier and intestinal epithelial endoplasmic reticulum (ER) stress contribute to necrotizing enterocolitis (NEC). Previously, we observed intestinal goblet cell loss and increased intestinal epithelial ER...
Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro [0.03%]
斑蛋白2通过调节蛋白质激酶C的活性调控体外肠道屏障功能
Simon Nagler,Yalda Ghoreishi,Catherine Kollmann et al.
Simon Nagler et al.
Previous data provided evidence for a critical role of desmosomes to stabilize intestinal epithelial barrier (IEB) function. These studies suggest that desmosomes not only contribute to intercellular adhesion but also play a role as signali...
Effect of altered human exposome on the skin and mucosal epithelial barrier integrity [0.03%]
暴露组学改变对皮肤和黏膜上皮屏障完整性的的影响
Yagiz Pat,Ismail Ogulur,Duygu Yazici et al.
Yagiz Pat et al.
Pollution in the world and exposure of humans and nature to toxic substances is continuously worsening at a rapid pace. In the last 60 years, human and domestic animal health has been challenged by continuous exposure to toxic substances an...
Amna N Naser,Qun Lu,Yan-Hua Chen
Amna N Naser
Tight junctions (TJs) are the most apical components of junctional complexes in epithelial and endothelial cells. Barrier function is one of the major functions of TJ, which restricts the ions and small water-soluble molecules from passing ...
Sena Babadag,Betül Çelebi-Saltik
Sena Babadag
Interstitial cells are present in the environment of stem cells in order to increase stem cell proliferation and differentiation and they are important to increase the efficiency of their transplantation. Telocytes (TCs) play an important r...
Neuroprotective effects of quercetin on the cerebellum of zinc oxide nanoparticles (ZnoNps)-exposed rats [0.03%]
檞皮素对锌氧化纳米颗粒暴露大鼠小脑的神经保护作用
Shaimaa A Abdelrahman,Amal S El-Shal,Abeer A Abdelrahman et al.
Shaimaa A Abdelrahman et al.
Engineered nanomaterials induce hazardous effects at the cellular and molecular levels. We investigated different mechanisms underlying the neurotoxic potential of zinc oxide nanoparticles (ZnONPs) on cerebellar tissue and clarified the ame...