You shall not pass: how complement C5 mediated antifungal immunity blocks systemic candidiasis and preserves renal tissue barriers [0.03%]
你休想通过：补体C5介导的抗真菌免疫如何阻止全身念珠菌感染并保持肾组织屏障功能
Dorrian G Cohen,Rebecca A Wingert
Dorrian G Cohen
The rising prevalence of fungal infections is a significant and growing public health threat, and this risk is further underscored by our incomplete understanding of why organs like the kidney are so susceptible to systemic candidiasis. To ...
Gene expression profiles of neonatal porcine Sertoli cells at baseline and after incubation in normal human serum as determined by RNA sequencing [0.03%]
RNA测序确定新生儿猪支持细胞基线和正常人血清培养后的基因表达谱
Rachel L Washburn,Jannette M Dufour
Rachel L Washburn
Sertoli cells are unique cells that contribute to the formation of the blood-testis barrier, which is important in sustaining the environment to promote spermatogenesis and to protect immunogenic germ cells from autoimmune destruction. This...
Ubiquitylated histone H2A: a molecular Jekyll and Hyde in the epidermis [0.03%]
表皮中的组蛋白H2A泛素化：天使还是魔鬼？
Lina Dagnino
Lina Dagnino
The epidermis of the skin provides a barrier between the organism and the external environment. It is constantly subjected to physical and chemical insults, and thus susceptible to wounding and to neoplastic transformation. Long-lasting epi...
Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier [0.03%]
生精小管血睾屏障通过支持细胞调节补体系统可能形成免疫特权环境
Rachel L Washburn,Jannette M Dufour
Rachel L Washburn
Sertoli cells are a crucial component of the blood-testis barrier (BTB), which isolates the adluminal compartment of the seminiferous tubules from the rest of the testis thus forming an environment to immunely protect the developing germ ce...
Swati Singh,Deepraj Paul,Virendra Nath et al.
Swati Singh et al.
Exosomes are membrane-bound micro-vesicles that possess endless therapeutic potential for treatment of numerous pathologies including autoimmune, cardiovascular, ocular, and nervous disorders. Despite considerable knowledge about exosome bi...
Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells [0.03%]
蛋白未折叠反应抑制增强内毒素诱导的牛肺动脉内皮细胞屏障功能障碍和炎症反应
Nektarios Barabutis,Mohammad S Akhter
Nektarios Barabutis
The development of novel strategies to counteract diseases related to barrier dysfunction is a priority, since sepsis and acute respiratory distress syndrome are still associated with high mortality rates. In the present study, we focus on ...
Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers [0.03%]
培养基和载体决定了类器官单层细胞的组成及屏障功能
Alicia M Barnett,Jane A Mullaney,Warren C McNabb et al.
Alicia M Barnett et al.
Intestinal organoid technology has revolutionized our approach to in vitro cell culture due in part to their three-dimensional structures being more like the native tissue from which they were derived with respect to cellular composition an...
Brittany E Watson,Julia A Miles,Melissa A Moss
Brittany E Watson
Blood barriers serve as key points of transport for essential molecules as well as lines of defense to protect against toxins. In vitro modeling of these barriers is common practice in the study of their physiology and related diseases. Thi...
Models for barrier understanding in health and disease in lab-on-a-chips [0.03%]
用于健康和疾病状况下实验室芯片障碍理解的模型
J Ponmozhi,S Dhinakaran,Dorottya Kocsis et al.
J Ponmozhi et al.
The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction of these barriers can lead to various pathological processes, including increased exposure to toxic materials and microorganisms. Various methods exis...
Brooke E Chambers,Nicole E Weaver,Caroline M Lara et al.
Brooke E Chambers et al.
Kidney disease is a devastating condition affecting millions of people worldwide, where over 100,000 patients in the United States alone remain waiting for a lifesaving organ transplant. Concomitant with a surge in personalized medicine, si...