Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier [0.03%]
生精小管血睾屏障通过支持细胞调节补体系统可能形成免疫特权环境
Rachel L Washburn,Jannette M Dufour
Rachel L Washburn
Sertoli cells are a crucial component of the blood-testis barrier (BTB), which isolates the adluminal compartment of the seminiferous tubules from the rest of the testis thus forming an environment to immunely protect the developing germ ce...
Swati Singh,Deepraj Paul,Virendra Nath et al.
Swati Singh et al.
Exosomes are membrane-bound micro-vesicles that possess endless therapeutic potential for treatment of numerous pathologies including autoimmune, cardiovascular, ocular, and nervous disorders. Despite considerable knowledge about exosome bi...
Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells [0.03%]
蛋白未折叠反应抑制增强内毒素诱导的牛肺动脉内皮细胞屏障功能障碍和炎症反应
Nektarios Barabutis,Mohammad S Akhter
Nektarios Barabutis
The development of novel strategies to counteract diseases related to barrier dysfunction is a priority, since sepsis and acute respiratory distress syndrome are still associated with high mortality rates. In the present study, we focus on ...
Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers [0.03%]
培养基和载体决定了类器官单层细胞的组成及屏障功能
Alicia M Barnett,Jane A Mullaney,Warren C McNabb et al.
Alicia M Barnett et al.
Intestinal organoid technology has revolutionized our approach to in vitro cell culture due in part to their three-dimensional structures being more like the native tissue from which they were derived with respect to cellular composition an...
Brittany E Watson,Julia A Miles,Melissa A Moss
Brittany E Watson
Blood barriers serve as key points of transport for essential molecules as well as lines of defense to protect against toxins. In vitro modeling of these barriers is common practice in the study of their physiology and related diseases. Thi...
Models for barrier understanding in health and disease in lab-on-a-chips [0.03%]
用于健康和疾病状况下实验室芯片障碍理解的模型
J Ponmozhi,S Dhinakaran,Dorottya Kocsis et al.
J Ponmozhi et al.
The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction of these barriers can lead to various pathological processes, including increased exposure to toxic materials and microorganisms. Various methods exis...
Brooke E Chambers,Nicole E Weaver,Caroline M Lara et al.
Brooke E Chambers et al.
Kidney disease is a devastating condition affecting millions of people worldwide, where over 100,000 patients in the United States alone remain waiting for a lifesaving organ transplant. Concomitant with a surge in personalized medicine, si...
Papart Rungrasameviriya,Aticha Santilinon,Palita Atichartsintop et al.
Papart Rungrasameviriya et al.
Defects of tight junction (TJ) are involved in many diseases related to epithelial cell functions, including kidney stone disease (KSD), which is a common disease affecting humans for over a thousand years. This review provides brief overvi...
House dust mite and Th2 cytokine-mediated epithelial barrier dysfunction attenuation by KL001 in 16-HBE cells [0.03%]
KL001通过抑制房尘螨诱导的上皮细胞TH2型细胞因子释放修复上皮屏障功能损伤
Santhosh Kumar Duraisamy,Ashokkumar Srinivasan,Isaac Kirubakaran Sundar
Santhosh Kumar Duraisamy
House dust mite (HDM) is a common aeroallergen that can disrupt the airway epithelial barrier leading to dysregulated immune response, resulting in allergic lung diseases such as asthma. Cryptochrome (CRY), a circadian clock gene, plays an ...
Genital epithelial barrier function is conserved by intravaginal rings releasing etonogestrel and ethinyl estradiol [0.03%]
含有依托孕醇和炔雌醇的阴道缓释环可保持生殖道上皮屏障功能
Mohan Liu,Rodolfo D Vicetti Miguel,Nirk E Quispe Calla et al.
Mohan Liu et al.
The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibili...