Ujval S Pathak,Aydan Mehralizade,Terry E Goldberg et al.
Ujval S Pathak et al.
Importance: Dementia develops in individuals with schizophrenia 4- to 20-fold more frequently than in the general population, but its etiology remains unexplained. ...
Interventions for Bereavement: What Works, What Does Not, and What Might [0.03%]
哀伤干预：哪些有效？哪些无效？以及将来可能有用的方法
Charles F Reynolds rd,Holly G Prigerson,M Katherine Shear et al.
Charles F Reynolds rd et al.
Shaddy K Saba,William B Weeks
Shaddy K Saba
Mirtazapine for Methamphetamine Use Disorder: A Randomized Clinical Trial [0.03%]
米塔扎平治疗甲基苯丙胺使用障碍的随机临床试验
Rebecca McKetin,Steven Shoptaw,Lucy Saunders et al.
Rebecca McKetin et al.
Importance: Methamphetamine use disorder is a global health challenge for which there are no approved pharmacotherapies. The safety and effectiveness of mirtazapine, a promising candidate for methamphetamine use disorder,...
Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia [0.03%]
整合多尺度精神分裂症研究的个性化细胞模型和深度表型构建方法
Florian J Raabe,David Popovic,Clara Vetter et al.
Florian J Raabe et al.
Importance: While growing evidence implicates synaptic dysfunction as a key pathophysiological mechanism in cognitive impairments in schizophrenia (SCZ), it remains unknown how individual alterations in synaptic connectiv...
Evaluation of Large Language Model Chatbot Responses to Psychotic Prompts [0.03%]
评估大型语言模型聊天机器人对精神病提示的回复
Elaine Shen,Fadi Hamati,Meghan Rose Donohue et al.
Elaine Shen et al.
GH001 vs Placebo in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial [0.03%]
抗药性抑郁患者中艾司西酞普兰(es许可西普兰)对照安慰剂的随机临床试验
Wieslaw J Cubala,Malek Bajbouj,Michael Bauer et al.
Wieslaw J Cubala et al.
Importance: Few pharmacotherapies are approved for treatment-resistant depression, and many patients do not achieve remission following treatment with those therapies. ...
Colm Healy,Kirstie O&#x;Hare,Ulla Lång et al.
Colm Healy et al.
Importance: Methylphenidate is the leading pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD) in childhood and adolescence. Individuals with ADHD have a higher risk of psychosis, but the long-te...
Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions: A Systematic Review and Meta-Analysis [0.03%]
一项系统评价和meta分析：在相同揭盲条件下，针对抑郁症，迷幻疗法与抗抑郁药的对照研究
Zachary J Williams,Hannah Barnett,Balázs Szigeti
Zachary J Williams
Importance: Psychedelic-assisted therapy (PAT) trials have high levels of functional unblinding, which biases results when comparing PAT with blinded interventions. Because PAT is effectively always open label, treatment ...
James I Hudson,Harrison G Pope Jr
James I Hudson