Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores [0.03%]
多基因评分背景下反复出现的拷贝数变异与精神疾病结局的关系
Morteza Vaez,Simone Montalbano,Ryan Waples et al.
Morteza Vaez et al.
Importance: Although both recurrent copy number variants (rCNVs) and polygenic scores (PGSs) impart risk for psychiatric disorders, it remains unclear how they contribute jointly to this risk. ...
Strategies for Establishing Clinical-Decision Thresholds in Psychiatry: A Review [0.03%]
精神病学中建立临床决策阈值的战略：一篇综述
Yuliya Kotelnikova,Lee Anna Clark,Camilo J Ruggero et al.
Yuliya Kotelnikova et al.
Importance: Nearly all psychopathology is inherently continuous, but both clinical practice and research often require categorical decisions (eg, treat or wait, pay for treatment or decline, enroll in study or not); there...
Apurva Parikh,Geoffrey Russell,Rachel Yehuda
Apurva Parikh
Melanie L Hill,Brandon Nichter,Ian C Fischer et al.
Melanie L Hill et al.
Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial [0.03%]
白细胞介素6作为抑郁症治疗靶点的概念验证随机临床试验
Éimear M Foley,Nicholas Turner,Ruta Margelyte et al.
Éimear M Foley et al.
Importance: Interleukin 6 (IL-6), a keystone inflammatory cytokine, is a credible mechanistic candidate for causing depression. However, randomized clinical trials testing its treatment potential remain scarce. ...
Structure of the Genetic Risks for Psychiatric Disorders in Swedish Population-Based Registries [0.03%]
基于瑞典人口登记的遗传风险的精神疾病谱系结构
Kenneth S Kendler,Henrik Ohlsson,Jan Sundquist et al.
Kenneth S Kendler et al.
Importance: Recent efforts to clarify the structure of the genetic risks for psychiatric disorders have been limited to disorders with large molecular samples. These heterogeneous samples have typically been ascertained f...
Laura M Rowland,Ellen E Lee
Laura M Rowland
Nationwide Transdiagnostic Age and Sex Patterns in Mental Disorder Disease Development [0.03%]
全国范围内精神疾病发展的跨诊断年龄和性别模式
Eva N S Wandall,Per K Andersen,Rune H B Christensen et al.
Eva N S Wandall et al.
Importance: Individuals with mental disorders often experience multiple disease episodes and diagnostic changes after initial psychiatric contact. However, studies that comprehensively investigate heterogeneity in disease...
Roy H Perlis
Roy H Perlis