Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial [0.03%]
首发精神病一种抗精神病药物治疗无效后的氯氮平临床试验研究
Xuan Li,Chang Lu,Zhaolin Zhai et al.
Xuan Li et al.
Importance: There is an urgent need for algorithm trials that address treatment steps in schizophrenia sequentially. Moreover, there is a debate about whether clozapine should be used after 1 failed antipsychotic drug tri...
AI in Mental Health Care-Opportunities and Risks Beyond Large Language Models [0.03%]
人工智能在心理健康护理中的机遇与风险——大型语言模型之外的视角
Loran Knol,Andre F Marquand,Nita Farahany et al.
Loran Knol et al.
Brendon Stubbs,Ruimin Ma,Megan Teychenne et al.
Brendon Stubbs et al.
Importance: Adults with severe mental illness (SMI) face a 10- to 20-year reduction in life expectancy, largely due to heightened cardiometabolic diseases. Low levels of physical activity (PA) and prolonged sedentary beha...
Comorbid Depression in Atopic Dermatitis-The Itch-to-Brain Circuitry Theory [0.03%]
特应性皮炎共病抑郁的“痒-脑”环路理论
Ian McConnell,John M Davis,Santosh Kumar Mishra
Ian McConnell
Climate-Related and Nature-Based Interventions for Mental Health: An Umbrella Review and Meta-Analysis [0.03%]
气候和基于自然的改善心理健康的干预措施：伞式综述和荟萃分析
Lasse Brandt,Michele De Prisco,Daniela Nocera et al.
Lasse Brandt et al.
Importance: Climate change is associated with increasing mental health morbidity and mortality. However, an umbrella review to classify and quantify the global evidence on climate-related and nature-based mental health in...
Health Plan Disenrollment and Mortality After Initiation of Medications for Opioid Use Disorder [0.03%]
戒断医疗计划与阿片类药物使用障碍患者开始药物治疗后的死亡率关系
Anh P Nguyen,Ingrid A Binswanger,Komal J Narwaney et al.
Anh P Nguyen et al.
Importance: Health plan disenrollment may interrupt treatment for opioid use disorder (OUD) and overall care, increasing risk for serious outcomes, including overdose and death. There is limited evidence on the associatio...
A Developmentally Informed Study of Sleep and Circadian Polygenic Scores in Adolescence [0.03%]
一项关于青春期睡眠和昼夜节律多基因评分的发育学研究
Katie J S Lewis,Joanna Martin,Jon Heron et al.
Katie J S Lewis et al.
Importance: Genome-wide association studies (GWAS) of sleep and circadian phenotypes have identified common genetic variants associated with these phenotypes in adults, but the relevance of these findings for younger age ...
Brain and Blood Biomarkers of Major Depressive Disorder: A Systematic Review [0.03%]
抑郁症的脑和血液生物标志物：系统性综述
Lia J Zallar,Maura B Dupont
Lia J Zallar
Importance: Major depressive disorder (MDD) is a debilitating neuropsychiatric disease associated with high risk of death by suicide. MDD is heterogeneous, and genome-wide association studies (GWASs) have established that...
Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks [0.03%]
基于形态相似网络拓扑偏差的精神分裂症亚型映射研究
Nanfang Pan,Yajing Long,Kun Qin et al.
Nanfang Pan et al.
Importance: Attention-deficit/hyperactivity disorder (ADHD) is characterized by considerable clinical heterogeneity, and existing classification frameworks constrain the development of neurobiologically informed subtyping...