Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals [0.03%]
澳大利亚医疗专业人员开展肌萎缩侧索硬化临床评估和管理过程中遇到的问题调查研究报告
Ines Semendric,Zachary Munn,Tom Jenkins et al.
Ines Semendric et al.
Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) inclu...
Benjamin Helmold,Carmel Armon,Michael Benatar et al.
Benjamin Helmold et al.
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). In this review, we explore the possibility of using ivermectin to slow ALS progression. Ivermectin's ability to modulate ...
The aging brain that doesn't fail: how neural resilience masks neurodegeneration [0.03%]
不易老化的大脑：神经复原力如何掩饰神经退行性病变
Andrew Eisen,Heather D Durham,Erik Pioro
Andrew Eisen
Neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease are usually framed as consequences of aging-related pathogenic processes, including impaired proteostasis with protein aggregatio...
SOD1-lowering therapy for patients with wildtype SOD1-ALS: a case report [0.03%]
针对SOD1野生型ALS患者的降低SOD1的治疗：个例报道
Nathan Carberry,Joanne Wuu,Michael Benatar
Nathan Carberry
Background and Objectives: To describe clinical and biomarker experience using an SOD1 antisense oligonucleotide (ASO) in a patient with non-SOD1 amyotrophic lateral sclerosis (ALS). Methods: Case report. Results: In a 72-year-old male with...
Intermuscular coherence as a candidate biomarker for primary lateral sclerosis [0.03%]
间肌内相干性作为原发性侧索硬化生物标志物的候选指标
Naoum P Issa,Elena Badillo-Goicoechea,Serdar Aydin et al.
Naoum P Issa et al.
Objective: Reliable and widely accessible neurophysiological biomarkers are needed to assess upper motor neuron (UMN) dysfunction. We investigated whether intermuscular coherence in the beta-gamma frequency range (IMCβγ) and its imaginary...
Feasibility and sensitivity of a multimodal digital endpoint panel for amyotrophic lateral sclerosis: a prospective cohort study [0.03%]
针对肌萎缩侧索硬化症的多模态数字终点面板的可行性与敏感性：前瞻性队列研究
Lianne C M Botman,Jordi W J van Unnik,Anita Beelen et al.
Lianne C M Botman et al.
Background: The use of digital technology may improve monitoring of amyotrophic lateral sclerosis (ALS) but a multimodal approach is likely required to capture the full disease phenotype. We evaluated the feasibility of a multimodal home mo...
Reduced penetrance in genetic ALS/FTD spectrum disorders: implications for genetic counseling, predictive testing and treatment [0.03%]
遗传性ALS/FTD谱系障碍中较低的外显率：对遗传咨询、预测检测和治疗的意义
Elizabeth A Harrington,Laynie Dratch,Tara A Jones et al.
Elizabeth A Harrington et al.
As the offer of genetic testing for people with ALS/FTD becomes standard of care, clinicians and affected individuals should have accurate and balanced information regarding the clinical and familial implications of test results, including ...
An open-label Phase 2a study of fasudil in amyotrophic lateral sclerosis: safety and exploratory endpoints [0.03%]
富舒令治疗肌萎缩侧索硬化症的开放标签二期临床试验：安全性和探索性指标研究
Claudia Pena,Casey Barker,Allison N Grossberg et al.
Claudia Pena et al.
Objectives: The primary objective was to assess the safety of oral fasudil in amyotrophic lateral sclerosis (ALS) patients. Changes in serum neurofilament light (NfL) levels and the ratio of phosphorylated to total AKT (p...
Noninvasive assessment of cardiovascular autonomic reflexes in amyotrophic lateral sclerosis: a systematic review [0.03%]
系统性回顾评估肌萎缩侧索硬化患者心血管自主神经反射的非侵入性方法
Sorfina Ilham Rozman,Nur Azah Hamzaid,Einly Lim et al.
Sorfina Ilham Rozman et al.
Dysautonomia is gradually recognized in amyotrophic lateral sclerosis (ALS), raising concerns of secondary complications from heightened autonomic burden. Autonomic disturbances, particularly cardiac dysautonomia, significantly impact patie...
The connection between unproven stem cell-based interventions and complementary and alternative medicine in crowdfunding for Amyotrophic Lateral Sclerosis [0.03%]
有关ALS的众筹中基于未经证实的干细胞干预与补充和替代医学之间的联系的研究
Michael Jewer,Jeremy Snyder,Timothy Caulfield et al.
Michael Jewer et al.
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disease associated with substantial medical and non‑medical costs. In the absence of effective treatments, patients and families may turn to crowdfund...