Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will [0.03%]
表观遗传编辑：任意调控基因表达的边缘试探者
David Cano-Rodriguez,Marianne G Rots
David Cano-Rodriguez
Genome targeting has quickly developed as one of the most promising fields in science. By using programmable DNA-binding platforms and nucleases, scientists are now able to accurately edit the genome. These DNA-binding tools have recently a...
Epigenetics, Media Coverage, and Parent Responsibilities in the Post-Genomic Era [0.03%]
表观遗传学、媒体关注及后基因组时代的父母责任
Martine Lappé
Martine Lappé
Environmental epigenetics is the study of how exposures and experiences can turn genes "on" or "off" without changing DNA sequence. By examining the influence that environmental conditions including diet, stress, trauma, toxins, and care ca...
Lulu I T Korsak,Molly E Mitchell,Katherine A Shepard et al.
Lulu I T Korsak et al.
RNA localization is a key mechanism in the regulation of protein expression. In neurons, this includes the axonal transport of select mRNAs based on the recognition of axonal localization motifs in these RNAs by RNA binding proteins. Bioinf...
Psychiatric Genetics in Child Custody Proceedings: Ethical, Legal, and Social Issues [0.03%]
儿童监护 proceedings中的精神病遗传学：伦理、法律和社会问题
Maya Sabatello,S Appelbaum
Maya Sabatello
This paper considers the ethical, legal, and social issues raised by the prospect of increasing use of psychiatric genetic data in child custody litigation. Although genetic tests cannot currently confirm a parent or child's psychiatric dia...
Genetic Counseling for Autism Spectrum Disorder in an Evolving Theoretical Landscape [0.03%]
理论发展中的自闭症谱系障碍的遗传咨询
Brenda Finucane,Scott M Myers
Brenda Finucane
Purpose of review: Psychiatry is steadily moving toward a new conceptualization of brain disorders that blurs long-held diagnostic distinctions among neurodevelopmental and psychiatric conditions, including autism. Genomi...
Jeffrey R Botkin,Erin Rothwell
Jeffrey R Botkin
Clinical applications of next generation sequencing are growing at a tremendous pace. Currently the largest application of genetic testing in medicine occurs with newborn screening through state-mandated public health programs, and there ar...
Alexis C Frazier-Wood
Alexis C Frazier-Wood
Lipoprotein subclass measures associate with cardiometabolic disease risk. Currently the information that lipoproteins convey on disease risk over that of traditional demographic and lipid measures is minimal, and so their use is clinics is...
Incidental Findings with Genomic Testing: Implications for Genetic Counseling Practice [0.03%]
基因检测中的偶然发现及其对遗传咨询实践的影响
Myra I Roche,Jonathan S Berg
Myra I Roche
This paper summarizes the current controversies surrounding the identification and disclosure of "incidental" or "secondary" findings from genomic sequencing and the implications for genetic counseling practice. The rapid expansion of clini...
Dale Muzzey,Eric A Evans,Caroline Lieber
Dale Muzzey
Identifying disease-causing mutations in DNA has long been the goal of genetic medicine. In the last decade, the toolkit for discovering DNA variants has undergone rapid evolution: mutations that were historically discovered by analog appro...
Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery [0.03%]
泛表型关联研究：利用全面的基因型和表型数据进行新发现
S A Pendergrass,M D Ritchie
S A Pendergrass
With the large volume of clinical and epidemiological data being collected, increasingly linked to extensive genotypic data, coupled with expanding high-performance computational resources, there are considerable opportunities for comprehen...