Science and Society: Pathways to Equitable Access and Delivery of Genomics Medicine in Africa [0.03%]
科学与社会：非洲基因组医学公平获取和交付的途径
Nchangwi Syntia Munung
Nchangwi Syntia Munung
Purpose of review: Recent advances in genetics are pushing the frontiers of health research in Africa. Notable developments include the release of the draft human pangenome reference, regulatory approval of gene editing t...
Detelina Grozeva,Salha Saad,Georgina E Menzies et al.
Detelina Grozeva et al.
Purpose of review: It is well established that sporadic Alzheimer's disease (AD) is polygenic with common and rare genetic variation alongside environmental factors contributing to disease. Here, we review our current und...
Expanding Use of cfDNA Screening in Pregnancy: Current and Emerging Ethical, Legal, and Social Issues [0.03%]
孕期间接受cfDNA筛查的现状及伦理、法律与社会问题的发展趋势
Lindsay Parham,Marsha Michie,Megan Allyse
Lindsay Parham
Purpose of review: In 2011, screening platforms became available in the US that detect and analyze fragments of cell-free placental DNA (cfDNA) in maternal blood serum. Marketed as noninvasive prenatal tests (NIPT), cfDNA...
Patricia Alejandra Castruita,Stefanie Danielle Piña-Escudero,Miguel E Rentería et al.
Patricia Alejandra Castruita et al.
Purpose of review: "Healthy aging" is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness. This literature review presents an overview of recent studies that expl...
Genodermatoses - Opportunities for Early Detection and Cancer Prevention [0.03%]
遗传性皮肤病与早期发现和癌症预防的机会
Helena Carley,Anjana Kulkarni
Helena Carley
Purpose of review: This review describes the clinical features of the major adult-onset genodermatosis-associated hereditary cancer predisposition syndromes. Diagnosis of these conditions can be challenging due to a wide ...
Updates in Prostate Cancer Research and Screening in Men at Genetically Higher Risk [0.03%]
遗传高风险男性前列腺癌研究和筛查的进展
Elizabeth K Bancroft,Holly Ni Raghallaigh,Elizabeth C Page et al.
Elizabeth K Bancroft et al.
Purpose of review: Prostate cancer (PrCa) is the most common cancer in men in the western world and is a major source of morbidity and mortality. Currently, general population PrCa screening is not recommended due to the ...
Horizon Scanning in Cancer Genomics: How Advances in Genomic Medicine Will Change Cancer Care Over the Next Decade [0.03%]
癌症基因组学的远景扫描——基因组医学的进展如何改变未来十年的癌症治疗
Lydia M Seed
Lydia M Seed
Purpose of review: Advances in genomic medicine have the potential to revolutionise cancer patient care by driving forwards the clinical practice of precision oncology. This review aims to outline how genomic medicine adv...
An update on the role of common genetic variation underlying substance use disorders [0.03%]
物质使用障碍的常见遗传变异作用研究进展更新
Emma C Johnson,Yoonhoo Chang,Arpana Agrawal
Emma C Johnson
Purpose of the review: Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss some next steps in addicti...
Phoebe Ellis,Ferenc Somogyvári,Dezső P Virok et al.
Phoebe Ellis et al.
Purpose of review: SARS-CoV-2, the recently emerged coronavirus (CoV) that is responsible for the current global pandemic Covid-19, first appeared in late 2019 in Wuhan, China. Here, we summarise details of the SARS-CoV-2...
Ishaan Gupta,Rohan Dandavate,Pallavi Gupta et al.
Ishaan Gupta et al.
Purpose of review: Alcohol use disorder (AUD) is a complex genetic disorder with very high heritability. This polygenic disorder not only results in increased morbidity and mortality, it is also a substantial social and e...