GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations [0.03%]
全基因组关联研究的未来：利用组学方法解释SNP相关性
Hung-Hsin Chen,Lauren E Petty,William Bush et al.
Hung-Hsin Chen et al.
Purpose of review: Neurodegenerative diseases, neuropsychiatric disorders, and related traits have highly complex etiologies but are also highly heritable and identifying the causal genes and biological pathways underlyin...
From Beyond the Grave: Use of Medical Information from the Deceased to Guide Care of Living Relatives [0.03%]
超越生死：利用死者医学信息指导在世亲属的治疗
Shereen Tadros,Helena Carley,Anneke Lucassen
Shereen Tadros
Purpose of review: In order to inform patients of their genetic risks, access to the medical records and/or stored samples of their relatives is often helpful. We consider some of the obstacles to such access when these r...
Shea J Andrews,Brian Fulton-Howard,Alison Goate
Shea J Andrews
Purpose of review: Over the last decade over 40 loci have been associated with risk of Alzheimer's disease (AD). However, most studies have either focused on identifying risk loci or performing unbiased screens without a ...
DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality [0.03%]
DNA甲基化和二型糖尿病：使用孟德尔随机化评估因果关系
Diana L Juvinao-Quintero,Marie-France Hivert,Gemma C Sharp et al.
Diana L Juvinao-Quintero et al.
Purpose of review: This review summarises recent advances in the field of epigenetics in order to understand the aetiology of type 2 diabetes (T2D). Recen...
Evaluating the Integration of Genomics into Cancer Screening Programmes: Challenges and Opportunities [0.03%]
癌症筛查项目中融入基因组学的挑战与机遇评估
Sarah Briggs,Ingrid Slade
Sarah Briggs
Purpose of review: As the costs of genomic testing have fallen, and our understanding of genetic susceptibility to cancers has grown, there has been increasing interest in incorporating testing for cancer susceptibility g...
Fabian V Filipp
Fabian V Filipp
Purpose of review: We critically evaluate the future potential of machine learning (ML), deep learning (DL), and artificial intelligence (AI) in precision medicine. The goal of this work is to show progress in ML in digit...
Daniel W Sirkis,Ethan G Geier,Luke W Bonham et al.
Daniel W Sirkis et al.
Purpose of review: In this review we highlight recent advances in the human genetics of frontotemporal dementia (FTD). In addition to providing a broad survey of genes implicated in FTD in the last several years, we also ...
Logan Dumitrescu,Elizabeth Rose Mayeda,Kavya Sharman et al.
Logan Dumitrescu et al.
Purpose of review: Summarize sex-specific contributors to the genetic architecture of Alzheimer's disease (AD). Recent findings: There ...
Rachel Horton,Anneke Lucassen
Rachel Horton
Purpose of review: Genomic tests offer increased opportunity for diagnosis, but their outputs are often uncertain and complex; results may need to be revised and/or may not be relevant until some future time. We discuss t...
Lawrence F Bielak,Patricia A Peyser
Lawrence F Bielak
Purpose of review: This review highlights recent findings regarding genetics of coronary artery calcification (CAC), a marker of subclinical atherosclerosis burden, that is a precursor of clinical coronary artery disease....