Colin A Kretz,Angela C Weyand,Jordan A Shavit
Colin A Kretz
Hemostasis, the process of blood clot formation and resolution in response to vascular injury, and thrombosis, the dysregulation of hemostasis leading to pathological clot formation, are widely studied. However, the genetic variability in h...
Takuto Chiba,Neil Hukriede,Mark P de Caestecker
Takuto Chiba
A number of genes involved in kidney development are reactivated in the adult after acute kidney injury (AKI). This has led to the belief that tissue repair mechanisms recapitulate pathways involved in embryonic development after AKI. We wi...
Key Fibrogenic Signaling [0.03%]
关键的纤维化信号通路
Weichun He,Chunsun Dai
Weichun He
Fibrosis is defined as an excessive accumulation of extracellular matrix components that lead to the destruction of organ architecture and impairment of organ function. Moreover, fibrosis is an intricate process attributable to a variety of...
Robert A McKee,Rebecca A Wingert
Robert A McKee
The renal system is vital to maintain homeostasis in the body, where the kidneys contain nephron functional units that remove metabolic waste from the bloodstream, regulate fluids, and balance electrolytes. Severe organ damage from toxins o...
Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish [0.03%]
去分化、转分化及增殖：斑马鱼心肌细胞再生的机制
Kazu Kikuchi
Kazu Kikuchi
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to tre...
Laura E McNamara,Lesley-Anne Turner,Karl V Burgess
Laura E McNamara
Systems biology is the creation of theoretical and mathematical models for the study of biological systems, as an engine for hypothesis generation and to provide context to experimental data. It is underpinned by the collection and analysis...
Regulation and Relevance of Myofibroblast Responses in Idiopathic Pulmonary Fibrosis [0.03%]
特发性肺纤维化中肌成纤维细胞反应的调节及意义
Meagan W Moore,Erica L Herzog
Meagan W Moore
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, incurable lung disease of unknown etiology with only limited treatment options. Current paradigms of disease pathogenesis feature recurrent or prolonged epithelial injury and an...
Vanessa Sauer,Namita Roy-Chowdhury,Chandan Guha et al.
Vanessa Sauer et al.
During the past decade, a series of discoveries has established the potential of the so called terminally differentiated cells to transition to more primitive progenitor cells. The dramatic demonstration of the ability to reprogram differen...
Rebecca G Wells
Rebecca G Wells
Portal fibroblasts are a minor population in the normal liver, found in the periportal mesenchyme surrounding the bile ducts. While many researchers have hypothesized that they are an important myofibroblast precursor population in biliary ...
Recent Advances in Understanding of NASH: MicroRNAs as Both Biochemical Markers and Players [0.03%]
近年来对NASH认知的进展：微小核糖核酸既是生化标志物也是参与者
Robert Vincent,Arun Sanyal
Robert Vincent
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatis (NASH) are becoming the dominant liver diseases in the US and Western World. Extensive work is being done to diagnose, understand, and explore the pathogenesis of these...