Nikolaos G Frangogiannis
Nikolaos G Frangogiannis
Activated myofibroblasts are key effector cells in tissue fibrosis. Emerging evidence suggests that myofibroblasts infiltrating fibrotic tissues originate predominantly from local mesenchyme-derived populations. Alterations in the extracell...
Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes [0.03%]
采用关键发育基因直接重编程生成胰腺β细胞
Claudia Cavelti-Weder,Weida Li,Adrian Zumsteg et al.
Claudia Cavelti-Weder et al.
Direct reprogramming is a promising approach for regenerative medicine whereby one cell type is directly converted into another without going through a multipotent or pluripotent stage. This reprogramming approach has been extensively explo...
Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver [0.03%]
脂联素作为抗纤维化和抗炎性脂肪细胞因子在肝脏中的作用
Pil-Hoon Park,Carlos Sanz-Garcia,Laura E Nagy
Pil-Hoon Park
Hepatic fibrosis is a dynamic process resulting from excessive deposition of extracellular matrix in the liver; uncontrolled progression of fibrosis can eventually lead to liver cirrhosis and/or hepatocellular carcinoma. The fibrogenic proc...
TNFα in liver fibrosis [0.03%]
肝纤维化中的TNFα
Yoon Mee Yang,Ekihiro Seki
Yoon Mee Yang
Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease. Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation and sustained liver inflammation leads to liver fibro...
Jun Xu,Xiao Liu,Bin Gao et al.
Jun Xu et al.
Alcoholic liver disease (ALD) is major cause of chronic liver injury which results in liver fibrosis and cirrhosis. According to the surveillance report published by the National Institute on Alcohol Abuse and Alcoholism, liver cirrhosis is...
Barbara Squiban,J Kimble Frazer
Barbara Squiban
Zebrafish (Danio rerio) are widely used for developmental biology studies. In the past decade, D. rerio have become an important oncology model as well. Leukemia is one type of cancer where zebrafish are particularly valuable. As vertebrate...
Elizabeth W Uhl,Natalie J Warner
Elizabeth W Uhl
Mice offer a number of advantages and are extensively used to model human diseases and drug responses. Selective breeding and genetic manipulation of mice have made many different genotypes and phenotypes available for research. However, in...
Emerging Roles of Herpesvirus microRNAs During In Vivo Infection and Pathogenesis [0.03%]
疱疹病毒microRNA在体内的感染和致病过程中的作用机制研究
Emily R Feldman,Scott A Tibbetts
Emily R Feldman
Herpesviridae constitutes a large family of double-stranded DNA viruses that are associated with a wide range of diseases, including herpetic lesions, birth defects, and cancer. Herpesviruses establish lifelong latent infections in part bec...
Lindsay Marjoram,Michel Bagnat
Lindsay Marjoram
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD...
Matthew C Salanga,Marko E Horb
Matthew C Salanga
Diseases affecting endodermal organs like the pancreas, lung and gastrointestinal (GI) tract have a substantial impact on human welfare. Since many of these are congenital defects that arise as a result of defects during development broad e...